Search Results - "Breese, G R"

Differential and persistent expression patterns of CNS gene transfer by an adeno-associated virus (AAV) vector by McCown, Thomas J., Xiao, Xiao, Li, Juan, Breese, George R., Jude Samulski, R.

“…Safe, long-term gene expression is a primary criteria for effective gene therapy in the brain, so studies were initiated to evaluate adeno-associated virus…”
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Basis of the Gabamimetic Profile of Ethanol by Breese, G. R., Criswell, H. E., Carta, M., Dodson, P. D., Hanchar, H. J., Khisti, R. T., Mameli, M., Ming, Z., Morrow, A. L., Olsen, R. W., Otis, T. S., Parsons, L. H., Penland, S. N., Roberto, M., Siggins, G. R., Valenzuela, C. F., Wallner, M.

“…This article summarizes the proceedings of a symposium held at the 2005 Research Society on Alcoholism meeting. The initial presentation by Dr. Wallner…”
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Neuroanatomical characterization of Fos induction in rat behavioral models of anxiety by Duncan, Gary E., Knapp, Darin J., Breese, George R.

“…Immunohistochemical staining for Fos-like immunoreactivity (Fos-LI) was used to map functional activation in discrete brain regions of rats processed in three…”
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Flumazenil blockade of anxiety following ethanol withdrawal in rats by MOY, S. S, KNAPP, D. J, CRISWELL, H. E, BREESE, G. R

“…In previous research, the drug flumazenil has been categorized both as a pure benzodiazepine antagonist and as a benzodiazepine partial agonist. The following…”
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Ontogeny of D1A and D2 dopamine receptor subtypes in rat brain using in situ hybridization and receptor binding by Schambra, U B, Duncan, G E, Breese, G R, Fornaretto, M G, Caron, M G, Fremeau, Jr, R T

“…The prenatal and postnatal ontogeny of D1A and D2 dopamine receptors was assessed by in situ hybridization of messenger RNAs encoding the receptors and by…”
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Influence of Age and Strain on Striatal Dopamine Loss in a Genetic Mouse Model of Lesch‐Nyhan Disease by Jinnah, H. A., Jones, M. D., Wojcik, B. E., Rothstein, J. D., Hess, E. J., Friedmann, T., Breese, G. R.

“…: Lesch‐Nyhan disease is a neurogenetic disorder caused by deficiency of the purine salvage enzyme hypoxanthine‐guanine phosphoribosyltransferase (HPRT)…”
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Localization of D1 dopamine receptor mRNA in brain supports a role in cognitive, affective, and neuroendocrine aspects of dopaminergic neurotransmission by R T Fremeau, Jr, G E Duncan, M G Fornaretto, A Dearry, J A Gingrich, G R Breese, M G Caron

“…Expression of a D1 dopamine receptor was examined in the rat brain by using a combination of in situ hybridization and in vitro receptor autoradiography. Cells…”
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Metabolic mapping of the rat brain after subanesthetic doses of ketamine: potential relevance to schizophrenia by Duncan, Gary E, Moy, Sheryl S, Knapp, Darin J, Mueller, Robert A, Breese, George R

“…Subanesthetic doses of ketamine have been shown to exacerbate symptoms in schizophrenia and to induce positive, negative, and cognitive schizophrenic-like…”
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Dopamine Transporters are Markedly Reduced in Lesch-Nyhan Disease in vivo by Wong, Dean F., Harris, James C., Naidu, Sakkubai, Yokoi, Fuji, Marenco, Stefano, Dannals, Robert F., Ravert, Hayden T., Yaster, Myron, Evans, Alan, Rousset, Olivier, Bryan, R. Nick, Gjedde, Albert, Kuhar, Michael J., Breese, George R.

“…Dopamine (DA) deficiency has been implicated in Lesch-Nyhan disease (LND), a genetic disorder that is characterized by hyperuricemia, choreoathetosis,…”
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Evidence for involvement of brain dopamine and other mechanisms in the behavioral action of the N-methyl-D-aspartic acid antagonist MK-801 in control and 6-hydroxydopamine-lesioned rats by Criswell, H E, Johnson, K B, Mueller, R A, Breese, G R

“…Behavioral activation following systemic administration of the N-methyl-D-aspartic acid receptor antagonist MK-801…”
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Topographic patterns of brain activity in response to swim stress: assessment by 2-deoxyglucose uptake and expression of Fos-like immunoreactivity by Duncan, GE, Johnson, KB, Breese, GR

“…Alterations in brain activity patterns were assessed in response to swim stress by immunocytochemical detection of Fos-like immunoreactivity (Fos-LI) and…”
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Induction of Fos-Like Proteins and Ultrasonic Vocalizations during Ethanol Withdrawal: Further Evidence for Withdrawal-Induced Anxiety by Knapp, Darin J., Duncan, Gary E., Crews, Fulton T., Breese, George R.

“…The ethanol withdrawal syndrome includes anxiety as a prominent symptom. Because the extent that specific regions of brain are critical to the generation of…”
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Site-specific enhancement of gamma-aminobutyric acid-mediated inhibition of neural activity by ethanol in the rat medial septal area by Givens, B S, Breese, G R

“…Because of uncertainty concerning the interaction of ethanol with gamma-aminobutyric acid (GABA) receptor-mediated events, the present work was designed to…”
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Functional classification of antidepressants based on antagonism of swim stress-induced fos-like immunoreactivity by Duncan, G E, Knapp, D J, Johnson, K B, Breese, G R

“…Autoradiographic analysis of 14C-2-deoxyglucose (2-DG) uptake and immunocytochemical assessment of Fos-like immunoreactivity (Fos-LI) were used to assess swim…”
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Ethanol inhibits NMDA-evoked electrophysiological activity in vivo by Simson, P E, Criswell, H E, Johnson, K B, Hicks, R E, Breese, G R

“…Recent studies have demonstrated that ethanol blocks N-methyl-D-aspartate (NMDA) responses in vitro. In the present study, evidence is provided that ethanol,…”
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Enhanced ultrasonic vocalization and Fos protein expression following ethanol withdrawal: effects of flumazenil by MOY, Sheryl S, KNAPP, Darin J, DUNCAN, Gary E, BREESE, George R

“…Administration of flumazenil, a benzodiazepine (BZD) antagonist, has therapeutic efficacy against some anxiogenic effects of ethanol withdrawal. This…”
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Pharmacology of the enantiomers of threo-methylphenidate by Patrick, K S, Caldwell, R W, Ferris, R M, Breese, G R

“…The pharmacology of the enantiomers of threo-methylphenidate (MPH) was evaluated in the rat to assess the relative contribution of each isomer to central and…”
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Effect of zolpidem on gamma-aminobutyric acid (GABA)-induced inhibition predicts the interaction of ethanol with GABA on individual neurons in several rat brain regions by Criswell, H E, Simson, P E, Knapp, D J, Devaud, L L, McCown, T J, Duncan, G E, Morrow, A L, Breese, G R

“…Previous investigations have suggested a relationship between zolpidem binding within specific brain regions and the ability of ethanol or zolpidem to enhance…”
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Evidence for a selective effect of ethanol on N-methyl-d-aspartate responses: ethanol affects a subtype of the ifenprodil-sensitive N-methyl-d-aspartate receptors by Yang, X, Criswell, H E, Simson, P, Moy, S, Breese, G R

“…An extracellular electrophysiological approach was used to determine the effect of ethanol on responses to N-methyl-D-aspartate (NMDA) across several brain…”
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Nicotine-induced inhibition in medial septum involves activation of presynaptic nicotinic cholinergic receptors on gamma-aminobutyric acid-containing neurons by Yang, X, Criswell, H E, Breese, G R

“…Neuronal responses to drugs acting on nicotinic cholinergic receptors (nAChRs) were examined in the rat medial septal area by using an in vivo extracellular…”
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