Search Results - "Breen, Michael S"

Epistasis as the primary factor in molecular evolution by Breen, Michael S., Kemena, Carsten, Vlasov, Peter K., Notredame, Cedric, Kondrashov, Fyodor A.

“…A comparison of more than 1,000 orthologues of diverse proteins shows that the rate of amino-acid substitution in recent evolution is an order of magnitude…”
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Large-scale proteomic analysis of human brain identifies proteins associated with cognitive trajectory in advanced age by Wingo, Aliza P., Dammer, Eric B., Breen, Michael S., Logsdon, Benjamin A., Duong, Duc M., Troncosco, Juan C., Thambisetty, Madhav, Beach, Thomas G., Serrano, Geidy E., Reiman, Eric M., Caselli, Richard J., Lah, James J., Seyfried, Nicholas T., Levey, Allan I., Wingo, Thomas S.

“…In advanced age, some individuals maintain a stable cognitive trajectory while others experience a rapid decline. Such variation in cognitive trajectory is…”
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Cellular and genetic drivers of RNA editing variation in the human brain by Cuddleston, Winston H., Li, Junhao, Fan, Xuanjia, Kozenkov, Alexey, Lalli, Matthew, Khalique, Shahrukh, Dracheva, Stella, Mukamel, Eran A., Breen, Michael S.

“…Posttranscriptional adenosine-to-inosine modifications amplify the functionality of RNA molecules in the brain, yet the cellular and genetic regulation of RNA…”
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Microenvironment Tracker (MicroTrac) model to estimate time-location of individuals for air pollution exposure assessments: model evaluation using smartphone data by Breen, Michael S., Xu, Yadong, Christopher Frey, H., Breen, Miyuki, Isakov, Vlad

“…Background A critical aspect of air pollution exposure assessments is determining the time spent in various microenvironments (ME), which can have…”
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Wearable and Non-Invasive Sensors for Rock Climbing Applications: Science-Based Training and Performance Optimization by Breen, Miyuki, Reed, Taylor, Nishitani, Yoshiko, Jones, Matthew, Breen, Hannah M, Breen, Michael S

“…Rock climbing has evolved from a method for alpine mountaineering into a popular recreational activity and competitive sport. Advances in safety equipment and…”
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PTSD Blood Transcriptome Mega-Analysis: Shared Inflammatory Pathways across Biological Sex and Modes of Trauma by Breen, Michael S, Tylee, Daniel S, Maihofer, Adam X, Neylan, Thomas C, Mehta, Divya, Binder, Elisabeth B, Chandler, Sharon D, Hess, Jonathan L, Kremen, William S, Risbrough, Victoria B, Woelk, Christopher H, Baker, Dewleen G, Nievergelt, Caroline M, Tsuang, Ming T, Buxbaum, Joseph D, Glatt, Stephen J

“…Transcriptome-wide screens of peripheral blood during the onset and development of posttraumatic stress disorder (PTSD) indicate widespread immune…”
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Integrating Wearable Sensors and Video to Determine Microlocation-Specific Physiologic and Motion Biometrics-Method Development for Competitive Climbing by Breen, Miyuki, Reed, Taylor, Breen, Hannah M, Osborne, Charles T, Breen, Michael S

“…Competitive indoor climbing has increased in popularity at the youth, collegiate, and Olympic levels. A critical aspect for improving performance is…”
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Gene expression analysis of TIL rich HPV-driven head and neck tumors reveals a distinct B-cell signature when compared to HPV independent tumors by Wood, Oliver, Woo, Jeongmin, Seumois, Gregory, Savelyeva, Natalia, McCann, Katy J, Singh, Divya, Jones, Terry, Peel, Lailah, Breen, Michael S, Ward, Matthew, Garrido Martin, Eva, Sanchez-Elsner, Tilman, Thomas, Gareth, Vijayanand, Pandurangan, Woelk, Christopher H, King, Emma, Ottensmeier, Christian

“…Human papilloma virus (HPV)-associated head and neck squamous cell carcinoma (HNSCC) has a better prognosis than it's HPV negative (HPV(-)) counterpart. This…”
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Transient peripheral blood transcriptomic response to ketamine treatment in children with ADNP syndrome by Buxbaum Grice, Ariela S., Sloofman, Laura, Levy, Tess, Walker, Hannah, Ganesh, Gauri, Rodriguez de los Santos, Miguel, Amini, Pardis, Buxbaum, Joseph D., Kolevzon, Alexander, Kostic, Ana, Breen, Michael S.

“…Activity-dependent neuroprotective protein (ADNP) syndrome is a rare neurodevelopmental disorder resulting in intellectual disability, developmental delay and…”
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Transcriptional signatures of participant-derived neural progenitor cells and neurons implicate altered Wnt signaling in Phelan-McDermid syndrome and autism by Breen, Michael S, Browne, Andrew, Hoffman, Gabriel E, Stathopoulos, Sofia, Brennand, Kristen, Buxbaum, Joseph D, Drapeau, Elodie

“…Phelan-McDermid syndrome (PMS) is a rare genetic disorder with high risk of autism spectrum disorder (ASD), intellectual disability, and language delay, and is…”
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Integrating Personal Air Sensor and GPS to Determine Microenvironment-Specific Exposures to Volatile Organic Compounds by Breen, Michael S., Isakov, Vlad, Prince, Steven, McGuinness, Kennedy, Egeghy, Peter P., Stephens, Brent, Arunachalam, Saravanan, Stout, Dan, Walker, Richard, Alston, Lillian, Rooney, Andrew A., Taylor, Kyla W., Buckley, Timothy J.

“…Personal exposure to volatile organic compounds (VOCs) from indoor sources including consumer products is an understudied public health concern. To develop and…”
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Prospective and detailed behavioral phenotyping in DDX3X syndrome by Tang, Lara, Levy, Tess, Guillory, Sylvia, Halpern, Danielle, Zweifach, Jessica, Giserman-Kiss, Ivy, Foss-Feig, Jennifer H, Frank, Yitzchak, Lozano, Reymundo, Belani, Puneet, Layton, Christina, Lerman, Bonnie, Frowner, Emanuel, Breen, Michael S, De Rubeis, Silvia, Kostic, Ana, Kolevzon, Alexander, Buxbaum, Joseph D, Siper, Paige M, Grice, Dorothy E

“…DDX3X syndrome is a recently identified genetic disorder that accounts for 1-3% of cases of unexplained developmental delay and/or intellectual disability (ID)…”
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Brain microRNAs are associated with variation in cognitive trajectory in advanced age by Wingo, Aliza P., Wang, Mengli, Liu, Jiaqi, Breen, Michael S., Yang, Hyun-Sik, Tang, Beisha, Schneider, Julie A., Seyfried, Nicholas T., Lah, James J., Levey, Allan I., Bennett, David A., Jin, Peng, De Jager, Philip L., Wingo, Thomas S.

“…In advancing age, some individuals maintain a stable cognitive performance over time, while others experience a rapid decline. Such variation in cognitive…”
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Endocrine disrupting chemicals in fish: Developing exposure indicators and predictive models of effects based on mechanism of action by Ankley, Gerald T., Bencic, David C., Breen, Michael S., Collette, Timothy W., Conolly, Rory B., Denslow, Nancy D., Edwards, Stephen W., Ekman, Drew R., Garcia-Reyero, Natalia, Jensen, Kathleen M., Lazorchak, James M., Martinović, Dalma, Miller, David H., Perkins, Edward J., Orlando, Edward F., Villeneuve, Daniel L., Wang, Rong-Lin, Watanabe, Karen H.

“…Knowledge of possible toxic mechanisms (or modes) of action (MOA) of chemicals can provide valuable insights as to appropriate methods for assessing exposure…”
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Systematic review of blood transcriptome profiling in neuropsychiatric disorders: guidelines for biomarker discovery by Breen, Michael S., Stein, Dan J., Baldwin, David S.

“…Introduction The utility of blood for genome‐wide gene expression profiling and biomarker discovery has received much attention in patients diagnosed with…”
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Transcriptional Modulation of Human Endogenous Retroviruses in Primary CD4+ T Cells Following Vorinostat Treatment by White, Cory H, Beliakova-Bethell, Nadejda, Lada, Steven M, Breen, Michael S, Hurst, Tara P, Spina, Celsa A, Richman, Douglas D, Frater, John, Magiorkinis, Gkikas, Woelk, Christopher H

“…The greatest obstacle to a cure for HIV is the provirus that integrates into the genome of the infected cell and persists despite antiretroviral therapy. A…”
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Large 22q13.3 deletions perturb peripheral transcriptomic and metabolomic profiles in Phelan-McDermid syndrome by Breen, Michael S., Fan, Xuanjia, Levy, Tess, Pollak, Rebecca M., Collins, Brett, Osman, Aya, Tocheva, Anna S., Sahin, Mustafa, Berry-Kravis, Elizabeth, Soorya, Latha, Thurm, Audrey, Powell, Craig M., Bernstein, Jonathan A., Kolevzon, Alexander, Buxbaum, Joseph D., Warfield, Simon K., Scherrer, Benoit, Filip-Dhima, Rajna, Dies, Kira, Siper, Paige, Hanson, Ellen, Phillips, Jennifer M.

“…Phelan-McDermid syndrome (PMS) is a rare neurodevelopmental disorder caused at least in part by haploinsufficiency of the SHANK3 gene, due to sequence variants…”
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Charting and probing the activity of ADARs in human development and cell-fate specification by Dailamy, Amir, Lyu, Weiqi, Nourreddine, Sami, Tong, Michael, Rainaldi, Joseph, McDonald, Daniella, Panwala, Rebecca, Muotri, Alysson, Breen, Michael S., Zhang, Kun, Mali, Prashant

“…Adenosine deaminases acting on RNA (ADARs) impact diverse cellular processes and pathological conditions, but their functions in early cell-fate specification…”
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Cell-Type-Specific Impact of Glucocorticoid Receptor Activation on the Developing Brain: A Cerebral Organoid Study by Cruceanu, Cristiana, Dony, Leander, Krontira, Anthi C, Fischer, David S, Roeh, Simone, Di Giaimo, Rossella, Kyrousi, Christina, Kaspar, Lea, Arloth, Janine, Czamara, Darina, Gerstner, Nathalie, Martinelli, Silvia, Wehner, Stefanie, Breen, Michael S, Koedel, Maik, Sauer, Susann, Sportelli, Vincenza, Rex-Haffner, Monika, Cappello, Silvia, Theis, Fabian J, Binder, Elisabeth B

“…Objective:A fine-tuned balance of glucocorticoid receptor (GR) activation is essential for organ formation, with disturbances influencing many health outcomes…”
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Mechanistic computational model of ovarian steroidogenesis to predict biochemical responses to endocrine active compounds by Breen, Michael S, Villeneuve, Daniel L, Breen, Miyuki, Ankley, Gerald T, Conolly, Rory B

“…Sex steroids, which have an important role in a wide range of physiological and pathological processes, are synthesized primarily in the gonads and adrenal…”
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