Search Results - "Breen, Kellie M"

Norepinephrine Neurons in the Nucleus of the Solitary Tract Suppress Luteinizing Hormone Secretion in Female Mice by McCosh, Richard B, Kreisman, Michael J, Tian, Katherine, Thomas, Steven A, Breen Church, Kellie M

“…Stress impairs fertility, at least in part, via inhibition of gonadotropin secretion. Luteinizing hormone (LH) is an important gonadotropin that is released in…”
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Estradiol Enables Chronic Corticosterone to Inhibit Pulsatile Luteinizing Hormone Secretion and Suppress Kiss1 Neuronal Activation in Female Mice by Kreisman, Michael J, McCosh, Richard B, Tian, Katherine, Song, Christopher I, Breen, Kellie M

“…Two common responses to stress include elevated circulating glucocorticoids and impaired luteinizing hormone (LH) secretion. We have previously shown that a…”
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Acute Psychosocial Stress Inhibits LH Pulsatility and Kiss1 Neuronal Activation in Female Mice by Yang, Jennifer A, Song, Christopher I, Hughes, Jessica K, Kreisman, Michael J, Parra, Ruby A, Haisenleder, Daniel J, Kauffman, Alexander S, Breen, Kellie M

“…Abstract Psychosocial stress, such as isolation and restraint, disrupts reproductive neuroendocrine activity. Here we investigate the impact of psychosocial…”
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Corticosterone Blocks Ovarian Cyclicity and the LH Surge via Decreased Kisspeptin Neuron Activation in Female Mice by Luo, Elena, Stephens, Shannon B. Z, Chaing, Sharon, Munaganuru, Nagambika, Kauffman, Alexander S, Breen, Kellie M

“…Stress elicits activation of the hypothalamic-pituitary-adrenal axis, which leads to enhanced circulating glucocorticoids, as well as impaired gonadotropin…”
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Extracellular Matrix Influences Gene Expression and Differentiation of Mouse Trophoblast Stem Cells by Natale, Bryony V, Kotadia, Ramie, Gustin, Katarina, Harihara, Anirudha, Min, Sarah, Kreisman, Michael J, Breen, Kellie M, Natale, David R C

“…Trophoblast stem (TS) cells were first isolated from the mouse placenta; however, little is known about their maintenance and niche in vivo. TS cells, like…”
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Insulin‐induced hypoglycaemia suppresses pulsatile luteinising hormone secretion and arcuate Kiss1 cell activation in female mice by McCosh, Richard B., Kreisman, Michael J., Tian, Katherine, Ho, Bryan S., Thackray, Varykina G., Breen, Kellie M.

“…Stress suppresses pulsatile luteinising hormone (LH) secretion in a variety of species, although the mechanism underlying this inhibition of reproductive…”
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Cortisol Reduces Gonadotropin-Releasing Hormone Pulse Frequency in Follicular Phase Ewes: Influence of Ovarian Steroids by Oakley, Amy E, Breen, Kellie M, Clarke, Iain J, Karsch, Fred J, Wagenmaker, Elizabeth R, Tilbrook, Alan J

“…Stress-like elevations in plasma glucocorticoids suppress gonadotropin secretion and can disrupt ovarian cyclicity. In sheep, cortisol acts at the pituitary to…”
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Does Cortisol Inhibit Pulsatile Luteinizing Hormone Secretion at the Hypothalamic or Pituitary Level? by Breen, Kellie M, Karsch, Fred J

“…Elevations in glucocorticoids suppress pulsatile LH secretion in sheep, but the neuroendocrine sites and mechanisms of this disruption remain unclear. Here, we…”
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Psychosocial Stress Inhibits Amplitude of Gonadotropin-Releasing Hormone Pulses Independent of Cortisol Action on the Type II Glucocorticoid Receptor by Wagenmaker, Elizabeth R, Breen, Kellie M, Oakley, Amy E, Tilbrook, Alan J, Karsch, Fred J

“…Our laboratory has developed a paradigm of psychosocial stress (sequential layering of isolation, blindfold, and predator cues) that robustly elevates cortisol…”
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Endocrine Basis for Disruptive Effects of Cortisol on Preovulatory Events by Breen, Kellie M, Billings, Heather J, Wagenmaker, Elizabeth R, Wessinger, Emily W, Karsch, Fred J

“…Stress activates the hypothalamo-pituitary-adrenal axis leading to enhanced glucocorticoid secretion and concurrently inhibits gonadotropin secretion and…”
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Allostasis in Neuroendocrine Systems Controlling Reproduction by Carrasco, Rodrigo A, Breen, Kellie M

“…Abstract Allostasis provides a supporting role to the homeostatic control of biological variables in mammalian species. While the concept of homeostasis is…”
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Neural and endocrine mechanisms underlying stress-induced suppression of pulsatile LH secretion by McCosh, Richard B., Breen, Kellie M., Kauffman, Alexander S.

“…Stress is well-known to inhibit a variety of reproductive processes, including the suppression of episodic Gonadotropin releasing hormone (GnRH) secretion,…”
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A Modified Ultra-Sensitive ELISA for Measurement of LH in Mice by Kreisman, Michael J, McCosh, Richard B, Breen, Kellie M

“…A major obstacle to monitoring pulsatile luteinizing hormone (LH) secretion in mice has been an assay with sufficient sensitivity in small blood volumes. In…”
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A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice1 by Kauffman, Alexander S, Thackray, Varykina G, Ryan, Genevieve E, Tolson, Kristen P, Glidewell-Kenney, Christine A, Semaan, Sheila J, Poling, Matthew C, Iwata, Nahoko, Breen, Kellie M, Duleba, Antoni J, Stener-Victorin, Elisabet, Shimasaki, Shunichi, Webster, Nicholas J, Mellon, Pamela L

“…Polycystic ovary syndrome (PCOS) pathophysiology is poorly understood, due partly to lack of PCOS animal models fully recapitulating this complex disorder…”
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Does Cortisol Acting Via the Type II Glucocorticoid Receptor Mediate Suppression of Pulsatile Luteinizing Hormone Secretion in Response to Psychosocial Stress? by Breen, Kellie M, Oakley, Amy E, Pytiak, Andrew V, Tilbrook, Alan J, Wagenmaker, Elizabeth R, Karsch, Fred J

“…This study assessed the importance of cortisol in mediating inhibition of pulsatile LH secretion in sheep exposed to a psychosocial stress. First, we developed…”
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Cortisol Interferes with the Estradiol-Induced Surge of Luteinizing Hormone in the Ewe by Wagenmaker, Elizabeth R, Breen, Kellie M, Oakley, Amy E, Pierce, Bree N, Tilbrook, Alan J, Turner, Anne I, Karsch, Fred J

“…Two experiments were conducted to test the hypothesis that cortisol interferes with the positive feedback action of estradiol that induces the luteinizing…”
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Neuroendocrine Basis for Disrupted Ovarian Cyclicity in Female Mice During Chronic Undernutrition by Kreisman, Michael J, Tadrousse, Kirollos S, McCosh, Richard B, Breen, Kellie M

“…Abstract Chronic undernutrition is a type of metabolic stress that impairs reproduction in multiple species. Although energy balance and female reproductive…”
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Regulation of the gonadotropin‐releasing hormone neuron during stress by McCosh, Richard B., O'Bryne, Kevin T., Karsch, Fred J., Breen, Kellie M.

“…The effect of stress on reproduction and gonadal function has captivated investigators for almost 100 years. Following the identification of…”
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A Novel Letrozole Model Recapitulates Both the Reproductive and Metabolic Phenotypes of Polycystic Ovary Syndrome in Female Mice by Kauffman, Alexander S, Thackray, Varykina G, Ryan, Genevieve E, Tolson, Kristen P, Glidewell-Kenney, Christine A, Semaan, Sheila J, Poling, Matthew C, Iwata, Nahoko, Breen, Kellie M, Duleba, Antoni J, Stener-Victorin, Elisabet, Shimasaki, Shunichi, Webster, Nicholas J, Mellon, Pamela L

“…Polycystic ovary syndrome (PCOS) pathophysiology is poorly understood, due partly to lack of PCOS animal models fully recapitulating this complex disorder…”
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Influence of stress-induced intermediates on gonadotropin gene expression in gonadotrope cells by Breen, Kellie M., Mellon, Pamela L.

“…•Glucocorticoids can inhibit reproductive activity.•Gonadotropin gene expression is altered by glucocorticoids.•Relevance of glucocorticoids to changes in LH…”
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