Search Results - "Breckenridge, Charles"

Association between Parkinson's Disease and Cigarette Smoking, Rural Living, Well-Water Consumption, Farming and Pesticide Use: Systematic Review and Meta-Analysis by Breckenridge, Charles B, Berry, Colin, Chang, Ellen T, Sielken, Jr, Robert L, Mandel, Jack S

“…Bradford Hill's viewpoints were used to conduct a weight-of-the-evidence assessment of the association between Parkinson's disease (PD) and rural living,…”
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Assessment of the Effects of MPTP and Paraquat on Dopaminergic Neurons and Microglia in the Substantia Nigra Pars Compacta of C57BL/6 Mice by Smeyne, Richard Jay, Breckenridge, Charles B, Beck, Melissa, Jiao, Yun, Butt, Mark T, Wolf, Jeffrey C, Zadory, Dan, Minnema, Daniel J, Sturgess, Nicholas C, Travis, Kim Z, Cook, Andrew R, Smith, Lewis L, Botham, Philip A

“…The neurotoxicity of paraquat dichloride (PQ) was assessed in two inbred strains of 9- or 16-week old male C57BL/6 mice housed in two different laboratories…”
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Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides by Breckenridge, Charles B., Holden, Larry, Sturgess, Nicholas, Weiner, Myra, Sheets, Larry, Sargent, Dana, Soderlund, David M., Choi, Jin-Sung, Symington, Steve, Clark, J. Marshall, Burr, Steve, Ray, David

“…Neurotoxicity and mechanistic data were collected for six α-cyano pyrethroids (β-cyfluthrin, cypermethrin, deltamethrin, esfenvalerate, fenpropathrin and…”
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Characterization of Activation of the Hypothalamic-Pituitary-Adrenal Axis by the Herbicide Atrazine in the Female Rat by Foradori, Chad D, Healy, Jessica E, Zimmerman, Arthur D, Kemppainen, Robert J, Jones, Melaney A, Read, Casey C, White, B Douglas, Yi, Kun Don, Hinds, Laura R, Lacagnina, Anthony F, Quihuis, Alicia M, Breckenridge, Charles B, Handa, Robert J

“…Atrazine (ATR) is a commonly used pre-emergence and early postemergence herbicide. Rats gavaged with ATR and its chlorometabolites desethylatrazine (DEA) and…”
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Toxicology and Epidemiology: Improving the Science with a Framework for Combining Toxicological and Epidemiological Evidence to Establish Causal Inference by Adami, Hans-Olov, Berry, Sir Colin L., Breckenridge, Charles B., Smith, Lewis L., Swenberg, James A., Trichopoulos, Dimitrios, Weiss, Noel S., Pastoor, Timothy P.

“…Historically, toxicology has played a significant role in verifying conclusions drawn on the basis of epidemiological findings. Agents that were suggested to…”
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Changes in hepatic phase I and phase II biotransformation enzyme expression and glutathione levels following atrazine exposure in female rats by Zimmerman, Arthur D., Breckenridge, Charles B., Yi, Kun D., Sawhney Coder, Pragati, Wanders, Desiree, Judd, Robert L., Foradori, Chad D.

“…1. To determine the effects of repeated atrazine (ATR) treatment on hepatic phase I and II enzymes, adult female rats were treated with vehicle or 100 mg/kg of…”
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Developmental Toxicity Studies with Atrazine and its Major Metabolites in Rats and Rabbits by Scialli, Anthony R., DeSesso, John M., Breckenridge, Charles B.

“…Atrazine (ATR), hydroxyatrazine (OH‐ATR), and the three chloro metabolites of ATR (deethylatrazine [DEA], deisopropylatrazine [DIA], diaminochlorotriazine…”
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Atrazine Inhibits Pulsatile Gonadotropin-Releasing Hormone (GnRH) Release Without Altering GnRH Messenger RNA or Protein Levels in the Female Rat by FORADORI, Chad D, ZIMMERMAN, Arthur D, HINDS, Laura R, ZULOAGA, Kristen L, BRECKENRIDGE, Charles B, HANDA, Robert J

“…Atrazine (ATR) is a commonly used pre-emergence/early postemergence herbicide. Previous work has shown that exposure to high doses of ATR in rats results in…”
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PBPK Model for Atrazine and Its Chlorotriazine Metabolites in Rat and Human by Campbell, Jr, Jerry L, Andersen, Melvin E, Hinderliter, Paul M, Yi, Kun Don, Pastoor, Timothy P, Breckenridge, Charles B, Clewell, 3rd, Harvey J

“…The previously-published physiologically based pharmacokinetic model for atrazine (ATZ), deisopropylatrazine (DIA), deethylatrazine (DEA), and…”
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PBPK-Based Probabilistic Risk Assessment for Total Chlorotriazines in Drinking Water by Breckenridge, Charles B, Campbell, Jerry L, Clewell, Harvey J, Andersen, Melvin E, Valdez-Flores, Ciriaco, Sielken, Jr, Robert L

“…The risk of human exposure to total chlorotriazines (TCT) in drinking water was evaluated using a physiologically based pharmacokinetic (PBPK) model. Daily TCT…”
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Neurotoxicity of paraquat and paraquat-induced mechanisms of developing Parkinson's disease by Cook, Andrew R, Botham, Philip A, Breckenridge, Charles B, Minnema, Daniel J, Sturgess, Nicholas C, Travis, Kim Z

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Atrazine and Breast Cancer: A Framework Assessment of the Toxicological and Epidemiological Evidence by Simpkins, James W., Swenberg, James A., Weiss, Noel, Brusick, David, Eldridge, J. Charles, Stevens, James T., Handa, Robert J., Hovey, Russell C., Plant, Tony M., Pastoor, Timothy P., Breckenridge, Charles B.

“…The causal relationship between atrazine exposure and the occurrence of breast cancer in women was evaluated using the framework developed by Adami et al…”
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The Differential Effect of Atrazine on Luteinizing Hormone Release in Adrenalectomized Adult Female Wistar Rats by FORADORI, Chad D, HINDS, Laura R, QUIHUIS, Alicia M, LACAGNINA, Anthony F, BRECKENRIDGE, Charles B, HANDA, Robert J

“…High doses of atrazine (ATR), administered for 4 days, suppress luteinizing hormone (LH) release and increase adrenal hormones levels. Considering the known…”
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Pharmacokinetic, neurochemical, stereological and neuropathological studies on the potential effects of paraquat in the substantia nigra pars compacta and striatum of male C57BL/6J mice by Breckenridge, Charles B., Sturgess, Nicholas C., Butt, Mark, Wolf, Jeffrey C., Zadory, Dan, Beck, Melissa, Mathews, James M., Tisdel, Merrill O., Minnema, Daniel, Travis, Kim Z., Cook, Andrew R., Botham, Philip A., Smith, Lewis L.

“…The pharmacokinetics and neurotoxicity of paraquat dichloride (PQ) were assessed following once weekly administration to C57BL/6J male mice by intraperitoneal…”
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Lack of immunotoxic effects of repeated exposure to atrazine associated with the adaptation of adrenal gland activation by Foradori, Chad D., Zimmerman, Arthur D., Coder, Pragati S., Peachee, Vanessa L., Handa, Robert J., Kimber, Ian, Pruett, Stephen B., Breckenridge, Charles B.

“…T cell-dependent IgM antibody production and natural killer cell (NKC) activity were assessed in SD rats orally administered atrazine for 28 days to males (0,…”
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The Effect of Atrazine Administered by Gavage or in Diet on the LH Surge and Reproductive Performance in Intact Female Sprague-Dawley and Long Evans Rats by Foradori, Chad D., Sawhney Coder, Prägati, Tisdel, Merrill, Yi, Kun Don, Simpkins, James W., Handa, Robert J., Breckenridge, Charles B.

“…Atrazine (ATR) blunts the hormone‐induced luteinizing hormone (LH) surge, when administered by gavage (50–100 mg/kg/day for 4 days), in ovariectomized rats. In…”
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Multigeneration Reproduction and Male Developmental Toxicity Studies on Atrazine in Rats by DeSesso, John M., Scialli, Anthony R., White, Tacey E. K., Breckenridge, Charles B.

“…BACKGROUND Reproductive toxicity of Atrazine (ATR) was evaluated in two rat multigenerational studies. Development of male reproductive parameters was…”
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Quantitative assessment of mammary gland development in female Long Evans rats following in utero exposure to atrazine by Hovey, Russell C, Coder, Pragati Sawhney, Wolf, Jeffrey C, Sielken, Jr, Robert L, Tisdel, Merrill O, Breckenridge, Charles B

“…In this study, we quantified the effects of in utero exposure to the herbicide atrazine on subsequent mammary gland development. Atrazine was administered to…”
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Effect of Age, Duration of Exposure, and Dose of Atrazine on Sexual Maturation and the Luteinizing Hormone Surge in the Female Sprague-Dawley Rat by Breckenridge, Charles B., Sawhney Coder, Pragati, Tisdel, Merrill O., Simpkins, James W., Yi, Kun Don, Foradori, Chad D., Handa, Robert J.

“…Atrazine (ATZ) was administered daily by gavage to pregnant female Sprague Dawley rats at doses of 0, 6.25, 25 or 50 mg/kg/day, either during gestation,…”
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Dietary administration of paraquat for 13weeks does not result in a loss of dopaminergic neurons in the substantia nigra of C57BL/6J mice by Minnema, Daniel J., Travis, Kim Z., Breckenridge, Charles B., Sturgess, Nicholas C., Butt, Mark, Wolf, Jeffrey C., Zadory, Dan, Beck, Melissa J., Mathews, James M., Tisdel, Merrill O., Cook, Andrew R., Botham, Philip A., Smith, Lewis L.

“…•Mice were exposed to at least 10.2mg paraquat/kg bw/day in the diet for 13weeks.•The exposure duration was sufficient to achieve a steady state brain…”
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