Search Results - "Breckenridge, Alasdair M"

Mini-Sentinel and Regulatory Science — Big Data Rendered Fit and Functional by Psaty, Bruce M, Breckenridge, Alasdair M

“…Under the leadership of the FDA and study investigators, the Mini-Sentinel project has not only transformed big medical data into a national research resource…”
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Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients by Pirmohamed, Munir, James, Sally, Meakin, Shaun, Green, Chris, Scott, Andrew K, Walley, Thomas J, Farrar, Keith, Park, B Kevin, Breckenridge, Alasdair M

“…Abstract Objective To ascertain the current burden of adverse drug reactions (ADRs) through a prospective analysis of all admissions to hospital. Design…”
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Report on the current status of the use of real‐world data (RWD) and real‐world evidence (RWE) in drug development and regulation by Breckenridge, Alasdair M., Breckenridge, Ross A., Peck, Carl C.

“…Radically expanding use of real‐world data (RWD) and real‐world evidence (RWE) holds the potential to substantially impact drug development, pharmaceutical…”
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Observations on Three Endpoint Properties and Their Relationship to Regulatory Outcomes of European Oncology Marketing Applications by Liberti, Lawrence, Stolk, Pieter, McAuslane, James Neil, Schellens, Jan, Breckenridge, Alasdair M., Leufkens, Hubert

“…Background. Guidance and exploratory evidence indicate that the type of endpoints and the magnitude of their outcome can define a therapy's clinical activity;…”
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Reporting of adverse drug reactions by nurses by Morrison-Griffiths, Sally, Walley, Thomas J, Park, B Kevin, Breckenridge, Alasdair M, Pirmohamed, Munir

“…Schemes for spontaneous reporting of adverse drug reactions are important to post-marketing safety surveillance worldwide. In the UK, doctors, dentists,…”
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The UK's NHS and pharma: need for more clinical pharmacologists by Aronson, Jeffrey K, Barnett, David B, Breckenridge, Alasdair M, Ferner, Robin E, Jackson, Peter, Maxwell, Simon R, McInnes, Gordon T, Rawlins, Michael D, Ritter, James M, Routledge, Philip, Walley, Tom J, Webb, David J, Williams, David, Woods, Kent L

“…The Wellcome Trust, recognising that clinical pharmacologists can contribute to research as well as teaching, has initiated interdisciplinary training…”
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Adverse drug reactions by Pirmohamed, Munir, Breckenridge, Alasdair M, Kitteringham, Neil R, Park, B Kevin

“…A problem with spontaneous reporting is that less than 10% of all serious and 2-4% of non-serious adverse reactions are reported. 2 38 All doctors need to be…”
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An investigation of the formation of cytotoxic, protein-reactive and stable metabolites from carbamazepine in vitro by Pirmohamed, M, Kitteringham, N R, Guenthner, T M, Breckenridge, A M, Park, B K

“…The formation of chemically reactive metabolites from carbamazepine (CBZ) in the presence of mouse and human liver microsomes has been investigated using…”
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Clinical pharmacokinetics of anthelmintic drugs by EDWARDS, G, BRECKENRIDGE, A. M

“…A rational strategy for chemotherapy demands that dosage schedules be based on an adequate knowledge of clinical and biochemical pharmacology. Many…”
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Effect of malaria infection and endotoxin-induced fever on phenacetin O-deethylation by rat liver microsomes by Kokwaro, G O, Glazier, A P, Ward, S A, Breckenridge, A M, Edwards, G

“…We have investigated the effect of malaria infection with the rodent parasite Plasmodium berghei and fever induced by Escherichia coli endotoxin on the…”
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Efficacy and safety of intermittent preventive treatment with sulfadoxine-pyrimethamine for malaria in African infants: a pooled analysis of six randomised, placebo-controlled trials by Aponte, John J, MD, Schellenberg, David, Prof, Egan, Andrea, PhD, Breckenridge, Alasdair, MD, Carneiro, Ilona, PhD, Critchley, Julia, PhD, Danquah, Ina, MPhil, Dodoo, Alexander, PhD, Kobbe, Robin, MD, Lell, Bertrand, MD, May, Jürgen, MD, Premji, Zul, MD, Sanz, Sergi, PhD, Sevene, Esperanza, MD, Soulaymani-Becheikh, Rachida, MD, Winstanley, Peter, MD, Adjei, Samuel, MD, Anemana, Sylvester, MD, Chandramohan, Daniel, MD, Issifou, Saadou, MD, Mockenhaupt, Frank, MD, Owusu-Agyei, Seth, MD, Greenwood, Brian, Prof, Grobusch, Martin P, Prof, Kremsner, Peter G, Prof, Macete, Eusebio, MD, Mshinda, Hassan, MD, Newman, Robert D, MD, Slutsker, Laurence, MD, Tanner, Marcel, Prof, Dr, Alonso, Pedro, Prof, Menendez, Clara, MD

“…Summary Background Intermittent preventive treatment (IPT) is a promising strategy for malaria control in infants. We undertook a pooled analysis of the safety…”
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Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients by MERRY, C, BARRY, M. G, MULCAHY, F, RYAN, M, HEAVEY, J, TJIA, J. F, GIBBONS, S. E, BRECKENRIDGE, A. M, BACK, D. J

“…The most important hepatic enzyme involved in the metabolism of protease inhibitors is cytochrome P450 3A4 (CYP3A4). Ritonavir (RIT) is a potent inhibitor of…”
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Fortnightly Review: Adverse Drug Reactions by Pirmohamed, Munir, Breckenridge, Alasdair M., Kitteringham, Neil R., Park, B. Kevin

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Interaction between diflunisal and warfarin by Serlin, M J, Mossman, S, Sibeon, R G, Tempero, K F, Breckenridge, A M

“…The effect of diflunisal on steady-state warfarin dynamics and kinetics was studied in five healthy men taking daily subtherapeutic doses of warfarin…”
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Diethylcarbamazine disposition in patients with onchocerciasis by Edwards, G, Awadzi, K, Breckenridge, A M, Gilles, H M, Orme, M L, Ward, S A

“…Diethylcarbamazine (DEC), 0.5 mg/kg, was taken orally by six patients being treated for onchocerciasis. Blood samples were taken at timed intervals for 48 hr…”
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Transcutaneous oxygen tension during exercise in patients with claudication by Roberts, David H, Breckenridge, Alasdair M, Linge, Keith

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The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites by Barry, M G, Khoo, S H, Veal, G J, Hoggard, P G, Gibbons, S E, Wilkins, E G, Williams, O, Breckenridge, A M, Back, D J

“…Zidovudine (ZDV) requires intracellular phosphorylation to ZDV triphosphate (ZDV-TP) prior to the inhibition of HIV replication. The effect of ZDV dose on the…”
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The pharmacokinetics of combination therapy with nelfinavir plus nevirapine by MERRY, C, BARRY, M. G, MULCAHY, F, RYAN, M, TJIA, J. F, HALIFAX, K. L, BRECKENRIDGE, A. M, BACK, D. J

“…To investigate the pharmacokinetics of nelfinavir (NFV) administered alone and in combination with nevirapine (NVP) to HIV-positive patients. Seven patients…”
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Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency by Pirmohamed, M, Williams, D, Tingle, M D, Barry, M, Khoo, S H, O'Mahony, C, Wilkins, E G, Breckenridge, A M, Park, B K

“…To determine whether HIV-infected patients have a deficiency of intracellular glutathione (GSH) in peripheral blood mononuclear cells (PBMC) and erythrocytes…”
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Adverse drug reactions by PIRMOHAMED, M, BRECKENRIDGE, A. M, KITTERINGHAM, N. R, PARK, B. K

“…Pirmohamed et al discuss the current status of adverse drug reactions, briefly describing the complexity of the more bizarre reactions and outlining a strategy…”
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