Search Results - "Breckenridge, A. M."

Adaptive licensing and facilitated regulatory pathways: A survey of stakeholder perceptions by Liberti, L, Stolk, P, McAuslane, N, Somauroo, A, Breckenridge, AM, Leufkens, HGM

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The burden of alcohol misuse on an inner‐city general hospital by Pirmohamed, M., Brown, C., Owens, L., Luke, C., Gilmore, I.T., Breckenridge, A.M., Park, B.K.

“…Alcohol consumption in the UK has been increasing steadily. We prospectively studied the burden on hospital services caused by overt alcohol misuse, in an…”
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Saquinavir pharmacokinetics alone and in combination with ritonavir in HIV-infected patients by MERRY, C, BARRY, M. G, MULCAHY, F, RYAN, M, HEAVEY, J, TJIA, J. F, GIBBONS, S. E, BRECKENRIDGE, A. M, BACK, D. J

“…The most important hepatic enzyme involved in the metabolism of protease inhibitors is cytochrome P450 3A4 (CYP3A4). Ritonavir (RIT) is a potent inhibitor of…”
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Adverse drug reactions as cause of admission to hospital: prospective analysis of 18 820 patients by Pirmohamed, Munir, James, Sally, Meakin, Shaun, Green, Chris, Scott, Andrew K, Walley, Thomas J, Farrar, Keith, Park, B Kevin, Breckenridge, Alasdair M

“…Abstract Objective To ascertain the current burden of adverse drug reactions (ADRs) through a prospective analysis of all admissions to hospital. Design…”
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In vitro activities of novel antifolate drug combinations against Plasmodium falciparum and human granulocyte CFUs by WINSTANLEY, P. A, MBERU, E. K, SZWANDT, I. S. F, BRECKENRIDGE, A. M, WATKINS, W. M

“…Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit StumbleUpon…”
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The use of cimetidine to reduce dapsone‐dependent methaemoglobinaemia in dermatitis herpetiformis patients by Coleman, MD, Rhodes, LE, Scott, AK, Verbov, JL, Friedmann, PS, Breckenridge, AM, Park, BK

“…1. We have attempted to reduce dapsone‐dependent methaemoglobinaemia formation in six dermatitis herpetiformis patients stabilised on dapsone by the…”
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The effect of zidovudine dose on the formation of intracellular phosphorylated metabolites by Barry, M G, Khoo, S H, Veal, G J, Hoggard, P G, Gibbons, S E, Wilkins, E G, Williams, O, Breckenridge, A M, Back, D J

“…Zidovudine (ZDV) requires intracellular phosphorylation to ZDV triphosphate (ZDV-TP) prior to the inhibition of HIV replication. The effect of ZDV dose on the…”
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Review of company postmarketing surveillance studies by Waller, P. C., Wood, S. M., Langman, M. J., Breckenridge, A. M., Rawlins, M. D.

“…OBJECTIVES--To review postmarketing surveillance studies sponsored by the pharmaceutical industry since the introduction of voluntary guidelines in 1987 and to…”
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The activation of the biguanide antimalarial proguanil co‐segregates with the mephenytoin oxidation polymorphism‐a panel study by Ward, SA, Helsby, NA, Skjelbo, E., Brosen, K., Gram, LF, Breckenridge, AM

“…The activation of the antimalarial drug proguanil (PG) to the active metabolite cycloguanil (CG) has been evaluated in a panel of 18 subjects. These subjects…”
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The pharmacokinetics of combination therapy with nelfinavir plus nevirapine by MERRY, C, BARRY, M. G, MULCAHY, F, RYAN, M, TJIA, J. F, HALIFAX, K. L, BRECKENRIDGE, A. M, BACK, D. J

“…To investigate the pharmacokinetics of nelfinavir (NFV) administered alone and in combination with nevirapine (NVP) to HIV-positive patients. Seven patients…”
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Urinary excretion of 6β-hydroxycortisol and the time course measurement of enzyme induction in man by OHNHAUS, E. E, BRECKENRIDGE, A. M, PARK, B. K

“…The effect of enzyme induction by antipyrine, phenobarbitone and rifampicin on the time-course of urinary 6 beta-hydroxycortisol (6 beta-OHC) excretion was…”
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Thrombosis prevention trial: randomised trial of low-intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease in men at increased risk by Meade, T W, Brennan, P J, Wilkes, H C, Zuhrie, S R

“…We aimed to evaluate low intensity oral anticoagulation with warfarin and low-dose aspirin in the primary prevention of ischaemic heart disease (IHD). 5499 men…”
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Intracellular glutathione in the peripheral blood cells of HIV-infected patients: failure to show a deficiency by Pirmohamed, M, Williams, D, Tingle, M D, Barry, M, Khoo, S H, O'Mahony, C, Wilkins, E G, Breckenridge, A M, Park, B K

“…To determine whether HIV-infected patients have a deficiency of intracellular glutathione (GSH) in peripheral blood mononuclear cells (PBMC) and erythrocytes…”
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The effect of various drugs on the glucuronidation of zidovudine (azidothymidine; AZT) by human liver microsomes by Sim, SM, Back, DJ, Breckenridge, AM

“…1. Zidovudine (3'‐azido‐3'‐deoxythymidine; AZT) is the drug of proven efficacy available for the treatment of patients with AIDS or ARC. It is eliminated…”
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Bioactivation of dapsone to a cytotoxic metabolite by human hepatic microsomal enzymes by Coleman, MD, Breckenridge, AM, Park, BK

“…1. Using human mononuclear leucocytes as target cells, we have investigated the bioactivation of dapsone (DDS) to a cytotoxic metabolite in the presence of…”
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Pharmacokinetics of halofantrine in man: effects of food and dose size by Milton, KA, Edwards, G, Ward, SA, Orme, ML, Breckenridge, AM

“…1. Plasma concentrations of halofantrine (Hf) and its putative principal plasma metabolite desbutyl halofantrine (Hfm) have been measured in two separate…”
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Clinical implications of enzyme induction and enzyme inhibition by Park, B K, Breckenridge, A M

“…The pharmacological effect of a drug is partly dependent upon its concentration at its site of action, which in turn is partly dependent upon its rate of…”
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The use of cimetidine as a selective inhibitor of dapsone N‐ hydroxylation in man by Coleman, MD, Scott, AK, Breckenridge, AM, Park, BK

“…1. The N‐hydroxylation of dapsone is thought to be responsible for the methaemoglobinaemia and haemolysis associated with this drug. We wished to investigate…”
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The binding of the antimalarial arteether to human plasma proteins in-vitro by Wanwimolruk, S, Edwards, G, Ward, S A, Breckenridge, A M

“…The binding of the novel antimalarial drug, arteether, to human plasma, pure albumin and alpha 1-acid glycoprotein has been investigated by ultrafiltration,…”
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Clinical pharmacokinetics of anthelmintic drugs by EDWARDS, G, BRECKENRIDGE, A. M

“…A rational strategy for chemotherapy demands that dosage schedules be based on an adequate knowledge of clinical and biochemical pharmacology. Many…”
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