Search Results - "Brecht, Ryan"
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Evolution of acyl-substrate recognition by a family of acyl-homoserine lactone synthases
Published in PloS one (17-11-2014)“…Members of the LuxI protein family catalyze synthesis of acyl-homoserine lactone (acyl-HSL) quorum sensing signals from S-adenosyl-L-methionine and an acyl…”
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Journal Article -
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Nucleolar localization of RAG1 modulates V(D)J recombination activity
Published in Proceedings of the National Academy of Sciences - PNAS (25-02-2020)“…V(D)J recombination assembles and diversifies Ig and T cell receptor genes in developing B and T lymphocytes. The reaction is initiated by the RAG1-RAG2…”
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Journal Article -
3
Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) activity is required for V(D)J recombination
Published in The Journal of experimental medicine (02-08-2021)“…A whole-genome CRISPR/Cas9 screen identified ATP2A2, the gene encoding the Sarco/endoplasmic reticulum Ca2+-ATPase (SERCA) 2 protein, as being important for…”
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Journal Article -
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Acyl-ACP Substrate Recognition in Burkholderia mallei BmaI1 Acyl-Homoserine Lactone Synthase
Published in Biochemistry (Easton) (07-10-2014)“…The acyl-homoserine lactone (AHL) autoinducer mediated quorum sensing regulates virulence in several pathogenic bacteria. The hallmark of an efficient quorum…”
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Journal Article -
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A Comparative Analysis of Acyl-Homoserine Lactone Synthase Assays
Published in Chembiochem : a European journal of chemical biology (14-12-2015)“…Quorum sensing is cell‐to‐cell communication that allows bacteria to coordinate attacks on their hosts by inducing virulent gene expression, biofilm…”
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Journal Article -
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Abstract P141: Preclinical characterization of LOX-24350, a highly potent and isoform-selective FGFR3 inhibitor
Published in Molecular cancer therapeutics (01-12-2021)“…Abstract Alterations in the fibroblast growth factor receptors (FGFRs) have been identified as oncogenic drivers in many human cancers. Specifically,…”
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Journal Article -
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Regulation and Targeting of V(D)J Recombination Through Rag Interactome Analysis
Published 01-01-2020“…V(D)J recombination assembles and diversifies immunoglobulin and T cell receptor genes in developing B and T lymphocytes. The reaction is initiated by the…”
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Dissertation -
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A Handicapper's Guide to Election '04
Published in Bloomberg businessweek (Online) (14-10-2004)“…One of the vacant Democratic seats appears to be in the GOP's grasp, with polls showing the Republican candidate for the vacant Georgia seat holding a…”
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Magazine Article -
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The Deficit: No Longer Quite So Scary
Published in Bloomberg businessweek (Online) (22-10-2003)“…LESS THREATENING RATIO. Still, the fiscal 2003 deficit and the budget outlook are less threatening when viewed as a percentage of gross domestic product…”
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Magazine Article -
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The Deficit May Be Back on a Leash
Published in Bloomberg businessweek (Online) (25-08-2003)“…As a percentage of GDP, this deficit should be well short of the record 5.7% in 1983. And looking ahead, a stronger economy, along with a reduced deficit,…”
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Magazine Article -
11
Buyers Will Keep the Home Fires Burning
Published in Bloomberg businessweek (Online) (07-08-2003)“…Low mortgage rates have been the linchpin of the residential housing market in recent years, as the relentless downtrend in rates allowed a whole new crop of…”
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Magazine Article -
12
War Swells the Tide of Red Ink
Published in Bloomberg businessweek (Online) (27-03-2003)“…A surge in supply of new Treasury issues will exacerbate the sharp rise in bond yields…”
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Magazine Article