Search Results - "Brebion, Franck"

Dechalcogenative Allylic Selenosulfide and Disulfide Rearrangements:  Complementary Methods for the Formation of Allylic Sulfides in the Absence of Electrophiles. Scope, Limitations, and Application to the Functionalization of Unprotected Peptides in Aqueous Media by Crich, David, Krishnamurthy, Venkataramanan, Brebion, Franck, Karatholuvhu, Maheswaran, Subramanian, Venkataraman, Hutton, Thomas K

“…Primary allylic selenosulfates (seleno Bunte salts) and selenocyanates transfer the allylic selenide moiety to thiols giving primary allylic selenosulfides,…”
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Enantioselective Synthesis of Thiosulfinates and of Acyclic Alkylidenemethylene Sulfide Sulfoxides by Colonna, Stefano, Pironti, Vincenza, Drabowicz, Jozef, Brebion, Franck, Fensterbank, Louis, Malacria, Max

“…Enantioselectivities up to 75 % have been found in the catalytic mono‐oxidation of di‐tert‐butyl disulfide and related compounds as well as of…”
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Discovery of GLPG1972/S201086, a Potent, Selective, and Orally Bioavailable ADAMTS‑5 Inhibitor for the Treatment of Osteoarthritis by Brebion, Franck, Gosmini, Romain, Deprez, Pierre, Varin, Marie, Peixoto, Christophe, Alvey, Luke, Jary, Hélène, Bienvenu, Natacha, Triballeau, Nicolas, Blanque, Roland, Cottereaux, Céline, Christophe, Thierry, Vandervoort, Nele, Mollat, Patrick, Touitou, Robert, Leonard, Philip, Ceuninck, Frédéric De, Botez, Iuliana, Monjardet, Alain, van der Aar, Ellen, Amantini, David

“…There are currently no approved disease-modifying osteoarthritis (OA) drugs (DMOADs). The aggrecanase ADAMTS-5 is key in the degradation of human aggrecan…”
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Allylic Disulfide Rearrangement and Desulfurization:  Mild, Electrophile-Free Thioether Formation from Thiols by Crich, David, Brebion, Franck, Krishnamurthy, Venkataramanan

“…Secondary and tertiary allylic 2-pyridyl and 2-benzothiazolyl disulfides react with thiol groups at room temperature to give secondary and tertiary allyl alkyl…”
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Sigmatropic Rearrangements as Tools for Amino Acid and Peptide Modification:  Application of the Allylic Sulfur Ylide Rearrangement to the Preparation of Neoglycoconjugates and Other Conjugates by Crich, David, Zou, Yekui, Brebion, Franck

“…Reaction of S-allyl cysteine derivatives, generated by the selenocysteine ligation, with rhodium carbenoids, stabilized and unstabilized, enables the…”
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Diastereoselective Synthesis of Enantiopure Acyclic β,β′-Disubstituted Vinylsulfoxides by Brebion, Franck, Goddard, Jean-Philippe, Fensterbank, Louis, Malacria, Max

“…Thermal elimination of sulfenic acid from enantiopure β,β′-disubstituted bis-sulfoxides allows the stereoselective synthesis of enantiopure acyclic…”
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Enantioselective alkene radical cations reactions by Crich, David, Shirai, Michio, Brebion, Franck, Rumthao, Sochanchingwung

“…The reaction of enantiomerically enriched 2-methyl-2-nitro-3-(diphenylphosphatoxy)alkyl radicals with tributyltin hydride and AIBN in benzene at reflux results…”
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Sigmatropic Rearrangements as Tools for Amino Acid and Peptide Modification: Application of the Allylic Sulfur Ylide Rearrangement to the Preparation of Neoglyco- and Other Conjugates by Crich, David, Zou, Yekui, Brebion, Franck

“…Reaction of S -allyl cysteine derivatives, generated by the selenocysteine ligation, with rhodium carbenoids, stabilized and unstabilized, enables the…”
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Bis-sulfoxides as ligands for platinum complexes by Mallorquin, Rocio Martinez, Chelli, Saloua, Brebion, Franck, Fensterbank, Louis, Goddard, Jean-Philippe, Malacria, Max

“…In this article, we describe two new platinum(II) complexes incorporating C 2-symmetric enantiopure bis-sulfoxides ligands. The originality of these structures…”
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Highly Diastereoselective Conjugate Addition to Alkylidene Bis(Sulfoxides): Asymmetric Synthesis of (+)-erythro-Roccellic Acid by Brebion, Franck, Delouvrié, Bénédicte, Nájera, Francisco, Fensterbank, Louis, Malacria, Max, Vaissermann, Jacqueline

“…Facial stereocontrol is possible in Michael additions of nucleophiles (Nu) to alkylidene bis(sulfoxides), which proceed via nonchelated (A) or chelated (B)…”
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Conjugate Additions to Alkylidene Bis(Sulfoxides) by Brebion, Franck, Vincent, Guillaume, Chelli, Saloua, Kwasnieski, Ophélie, Najera, Francisco, Delouvrié, Bénédicte, Marek, Ilan, Derat, Etienne, Goddard, Jean-Philippe, Malacria, Max, Fensterbank, Louis

“…A general study on the conjugate addition of anionic nucleophiles to alkylidene bis(sulfoxides) is presented. Alkoxides gave high yielding and…”
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1-Phosphanorbornadiene-imines and amines in enantioselective allylic C- and N-alkylation by Mercier, François, Brebion, Franck, Dupont, Romain, Mathey, François

“…The reaction of enantiopure 2-formyl-1-phosphanorbornadiene 3 with primary amines at room temperature in the presence of an acid catalyst gives the…”
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Enantiopure alkylidene-1,1-bis- p-tolylsulfoxides as new partners in diastereoselective radical cyclizations by Brebion, Franck, Vitale, Maxime, Fensterbank, Louis, Malacria, Max

“…Enantiopure alkylidene-1,1-bis- p-tolylsulfoxides have been used as new partners in diastereoselective radical cyclizations. An efficient and highly…”
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New Advances in Bis(Sulfoxides) Chemistry by Beauvière, Sophie, Brebion, Franck, Chelli, Saloua, Delouvrié, Bénédicte, Gomez, Catherine, Kwasnieski, Ophélie, Mallorquin, Rocio Martinez, Najera, Francisco, Vincent, Guillaume, Vitale, Maxime R., Derat, Etienne, Marek, Ilan, Malacria, Max, Goddard, Jean-Philippe, Fensterbank, Louis

“…The chemistry of bis(sulfoxides) is discussed from two starting materials, (Ss,Ss)-bis-p-tolylsulfinylmethane and (Ss,Ss)-bis-p-tolylsulfinyl alkylidenes…”
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Highly Diastereoselective Conjugate Addition to Alkylidene Bis(Sulfoxides): Asymmetric Synthesis of (+)-erythro-Roccellic Acid by Brebion, Franck, Delouvrié, Bénédicte, Nájera, Francisco, Fensterbank, Louis, Malacria, Max, Vaissermann, Jacqueline

“…Faciale Stereokontrolle ist möglich bei Additionen von Nucleophilen (Nu) an Alkylidenbis(sulfoxide): In Gegenwart geeigneter Lewis‐Säuren (LA) erfolgt die…”
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