Search Results - "Brebion, F."

Pharmacological characterization of GLPG1972/S201086, a potent and selective small-molecule inhibitor of ADAMTS5 by Clement-Lacroix, P., Little, C.B., Smith, M.M., Cottereaux, C., Merciris, D., Meurisse, S., Mollat, P., Touitou, R., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., Lepescheux, L., van der Aar, E., Christophe, T., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.

“…A disintegrin and metalloproteinase with thrombospondin motifs 5 (ADAMTS5) is a key enzyme in degradation of cartilage in osteoarthritis (OA). We report the…”
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GLPG1972: a potent, selective, orally available adamts-5 inhibitor for the treatment of OA by Clement-Lacroix, P, Little, C, Meurisse, S, Blanqué, R, Mollat, P, Brebion, F, Gosmini, R, De Ceuninck, F, Botez, I, Lepescheux, L, van der Aar, E, Christophe, T, Vandervoort, N, Cottereaux, C, Comas, D, Deprez, P, Amantini, D

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ADAMTS-5 inhibition with the potent and highly selective inhibitor GLPG1972 results in strong disease-modifying OA drug effects in the rat meniscectomy model by Clement-Lacroix, P., Meurisse, S., Lepescheux, L., Merciris, D., Borgonovi, M., Cottereaux, C., Mollat, P., Brebion, F., Gosmini, R., De Ceuninck, F., Botez, I., Christophe, T., van der Aar, E.E., Vandervoort, N., Blanqué, R., Comas, D., Deprez, P., Amantini, D.

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Highly Diastereoselective Conjugate Addition to Alkylidene Bis(Sulfoxides): Asymmetric Synthesis of (+)-erythro-Roccellic Acid by Brebion, Franck, Delouvrié, Bénédicte, Nájera, Francisco, Fensterbank, Louis, Malacria, Max, Vaissermann, Jacqueline

“…Facial stereocontrol is possible in Michael additions of nucleophiles (Nu) to alkylidene bis(sulfoxides), which proceed via nonchelated (A) or chelated (B)…”
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1-Phosphanorbornadiene-imines and amines in enantioselective allylic C- and N-alkylation by Mercier, François, Brebion, Franck, Dupont, Romain, Mathey, François

“…The reaction of enantiopure 2-formyl-1-phosphanorbornadiene 3 with primary amines at room temperature in the presence of an acid catalyst gives the…”
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Enantiopure alkylidene-1,1-bis- p-tolylsulfoxides as new partners in diastereoselective radical cyclizations by Brebion, Franck, Vitale, Maxime, Fensterbank, Louis, Malacria, Max

“…Enantiopure alkylidene-1,1-bis- p-tolylsulfoxides have been used as new partners in diastereoselective radical cyclizations. An efficient and highly…”
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Enantioselective Synthesis of Thiosulfinates and of Acyclic Alkylidenemethylene Sulfide Sulfoxides by Colonna, Stefano, Pironti, Vincenza, Drabowicz, Jozef, Brebion, Franck, Fensterbank, Louis, Malacria, Max

“…Enantioselectivities up to 75 % have been found in the catalytic mono‐oxidation of di‐tert‐butyl disulfide and related compounds as well as of…”
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