Search Results - "Breau, Alan P"

Development and validation of a liquid chromatography–tandem mass spectrometric assay for Eplerenone and its hydrolyzed metabolite in human plasma by Zhang, Ji Y., Fast, Douglas M., Breau, Alan P.

“…A sensitive and specific liquid chromatography–tandem mass spectrometry assay was developed to quantify the first selective aldosterone blocker Eplerenone (I)…”
Get full text

Use of surface plasmon resonance biosensor technology as a possible alternative to detect differences in binding of enantiomeric drug compounds to immobilized albumins by Ahmad, Ateeq, Ramakrishnan, Anand, McLean, Matthew A, Breau, Alan P

“…The use of biosensors for monitoring real time interactions between biomolecules and drug compounds has a lot of advantages over presently existing detection…”
Get full text

Determination of valdecoxib and its metabolites in human urine by automated solid-phase extraction–liquid chromatography–tandem mass spectrometry by Zhang, Ji Y., Fast, Douglas M., Breau, Alan P.

“…A simple, sensitive and specific automated SPE–LC–MS–MS assay was developed and validated for determination of valdecoxib (I), its hydroxylated metabolite (II)…”
Get full text

Pharmacokinetics and Metabolism of a COX-2 Inhibitor, Valdecoxib, in Mice by ZHANG, Ji Y, YUAN, Josh J, WANG, Yue-Fen, BIBLE, Roy H, BREAU, Alan P

“…The pharmacokinetics and metabolism of valdecoxib, a potent cyclooxygenase-2 selective inhibitor, were investigated in mice. Valdecoxib was extensively…”
Get full text

Involvement of Human UGT2B7 and 2B15 in Rofecoxib Metabolism by ZHANG, Ji Y, ZHAN, Jenny, COOK, Chyung S, INGS, Robert M, BREAU, Alan P

“…O -Glucuronidation of 5-hydroxyrofecoxib is the major biotransformation pathway of rofecoxib in human, rat, and dog. The glucuronide conjugate is also involved…”
Get full text

Characterization of metabolites of Celecoxib in rabbits by liquid chromatography/tandem mass spectrometry by Zhang, Ji Y., Wang, YueFen, Dudkowski, Caroline, Yang, Dai-chang, Chang, Ming, Yuan, Jinhua, Paulson, Susan K., Breau, Alan P.

“…The metabolism of the anti‐inflammatory drug Celecoxib in rabbits was characterized using liquid chromatography (LC)/tandem mass spectrometry (MS/MS) with…”
Get full text

Pharmacokinetics, Tissue Distribution, Metabolism, and Excretion of Celecoxib in Rats by PAULSON, S. K, ZHANG, J. Y, MAZIASZ, T. J, SCHOENHARD, G. L, BURTON, E. G, BREAU, A. P, HRIBAR, J. D, LIU, N. W. K, JESSEN, S. M, LAWAL, Y. M, COGBURN, J. N, GRESK, C. J, MARKOS, C. S

“…The pharmacokinetics, tissue distribution, metabolism, and excretion of celecoxib, 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1 H -pyrazol-1-yl]…”
Get full text

Metabonomic evaluation of idiosyncrasy-like liver injury in rats cotreated with ranitidine and lipopolysaccharide by Maddox, Jane F., Luyendyk, James P., Cosma, Gregory N., Breau, Alan P., Bible, Roy H., Harrigan, George G., Goodacre, Royston, Ganey, Patricia E., Cantor, Glenn H., Cockerell, Gary L., Roth, Robert A.

“…Idiosyncratic liver injury occurs in a small fraction of people on certain drug regimens. The cause of idiosyncratic hepatotoxicity is not known; however, it…”
Get full text

Development and validation of an automated SPE-LC-MS/MS assay for valdecoxib and its hydroxylated metabolite in human plasma by Zhang, Ji Y, Fast, Douglas M, Breau, Alan P

“…A sensitive and specific liquid chromatography-tandem mass spectrometry assay was developed to quantitate valdecoxib (I) and its hydroxylated metabolite (II)…”
Get full text

Collision-induced dissociation of valdecoxib metabolites: a novel rearrangement involving an isoxazole ring by Zhang, Ji Y., Xu, Fran, Breau, Alan P.

“…Valdecoxib is a potent COX‐2 inhibitor. During metabolism studies of valdecoxib by liquid chromatography/tandem mass spectrometry, we observed a novel mass…”
Get full text

A validated SPE–LC-MS/MS assay for Eplerenone and its hydrolyzed metabolite in human urine by Zhang, Ji Y, Fast, Douglas M, Breau, Alan P

“…An automated LC-MS/MS assay was validated to quantitate the first selective aldosterone blocker Eplerenone (I) and its hydrolyzed metabolite (II) in human…”
Get full text

Disposition and pharmacokinetics of L-N6-(1-iminoethyl)lysine-5-tetrazole-amide, a selective iNOS inhibitor, in rats by Zhang, Ji Y, Wang, Yuefen, Milton, Mark N, Kraus, Lori, Breau, Alan P, Paulson, Susan K

“…The metabolism, pharmacokinetics, tissue distribution, and excretion of L-N6-(1-iminoethyl)lysine-5-tetrazole-amide (L-NIL-TA), a selective inducible NO…”
Get more information

Use of Optical Biosensor Technology to Study Immunological Cross-Reactivity between Different Sulfonamide Drugs by Ahmad, Ateeq, Ramakrishnan, Anand, McLean, Matthew A., Li, Dongbei, Rock, Marie T., Karim, Aziz, Breau, Alan P.

“…Adverse reactions to medications account for a substantial number of hospitalizations and in some cases fatalities. The nature of the many drug–drug…”
Get full text

Determination of free levels of phenytoin in human plasma by liquid chromatography/tandem mass spectrometry by Bardin, Sofiya, Ottinger, James C, Breau, Alan P, O'Shea, Thomas J

“…A liquid chromatography combined with tandem mass spectrometry assay for the determination of free levels of the highly protein bound drug phenytoin…”
Get full text

Effects of LY295427, a low-density lipoprotein (LDL) receptor up-regulator, on LDL receptor gene transcription and cholesterol metabolism in normal and hypercholesterolemic hamsters by Bensch, W R, Gadski, R A, Bean, J S, Beavers, L S, Schmidt, R J, Perry, D N, Murphy, A T, McClure, D B, Eacho, P I, Breau, A P, Archer, R A, Kauffman, R F

“…The action of LY295427 [(3alpha,4alpha, 5alpha)-4-(2-propenylcholestan-3-ol)], a compound that derepresses low-density lipoprotein receptor (LDL-R) expression…”
Get more information

Contemporary issues in toxicology the role of metabonomics in toxicology and its evaluation by the COMET project by Lindon, John C, Nicholson, Jeremy K, Holmes, Elaine, Antti, Henrik, Bollard, Mary E, Keun, Hector, Beckonert, Olaf, Ebbels, Timothy M, Reily, Michael D, Robertson, Donald, Stevens, Gregory J, Luke, Peter, Breau, Alan P, Cantor, Glenn H, Bible, Roy H, Niederhauser, Urs, Senn, Hans, Schlotterbeck, Goetz, Sidelmann, Ulla G, Laursen, Steen M, Tymiak, Adrienne, Car, Bruce D, Lehman-McKeeman, Lois, Colet, Jean-Marie, Loukaci, Ali, Thomas, Craig

“…The role that metabonomics has in the evaluation of xenobiotic toxicity studies is presented here together with a brief summary of published studies. To…”
Get full text

Thiono compounds. 4. In vitro mutagenic and antineoplastic activity of TEPA and thio-TEPA by Breau, A P, Field, L, Mitchell, W M

“…Tris (1-aziridinyl) phosphine oxide (TEPA) and tris (1-aziridinyl) phosphine sulfide (thio-TEPA) induced base pair mutations in the Ames mutagenic assay…”
Get full text

Plasma protein binding of celecoxib in mice, rat, rabbit, dog and human by Paulson, Susan K., Kaprak, Todd A., Gresk, Christopher J., Fast, Douglas M., Baratta, Mike T., Burton, Earl G., Breau, Alan P., Karim, Aziz

“…The plasma protein binding of celecoxib was determined for animals and humans using in vitro and ex vivo methods. Eight, healthy, human volunteers (three male,…”
Get full text

Oxidative and reductive metabolism of 9-cis-retinoic acid in the rat. Identification of 13,14-dihydro-9-cis-retinoic acid and its taurine conjugate by Shirley, M A, Bennani, Y L, Boehm, M F, Breau, A P, Pathirana, C, Ulm, E H

“…9-cis-Retinoic acid (9-cis-RA), a hormone that binds and activates all known retinoid receptor subtypes, is structurally similar to all-trans-retinoic acid and…”
Get more information

Mutagenic and cell transformation activities of representative phosphorothioate esters in vitro by Breau, A P, Mitchell, W M, Swinson, J, Field, L

“…Five alkyl and five aryl phosphorothioates are ranked relative to parathion in effectiveness as base-pair mutagens in the Ames mutagenic assay. Three in each…”
Get more information