Search Results - "Breakefield, XO"

Extracellular vesicles: biology and emerging therapeutic opportunities by EL Andaloussi, Samir, Mäger, Imre, Breakefield, Xandra O., Wood, Matthew J. A.

“…Extracellular vesicles have emerged as important mediators of intercellular communication, and they are now implicated in numerous biological and pathological…”
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Codon-optimized Gaussia luciferase cDNA for mammalian gene expression in culture and in vivo by Tannous, Bakhos A, Kim, Dong-Eog, Fernandez, Juliet L, Weissleder, Ralph, Breakefield, Xandra O

“…Photoproteins have played a major role in advancing our understanding of biological processes. A broader array of biocompatible, nontoxic, and novel reporters…”
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Viral vectors for gene delivery to the nervous system by Davidson, Beverly L, Breakefield, Xandra O

“…Our ability to manipulate the genetic constitution of the nervous system has come of age with various technologies, including virus vectors that can…”
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Degradation of fibrillar collagen in a human melanoma xenograft improves the efficacy of an oncolytic herpes simplex virus vector by MCKEE, Trevor D, GRANDI, Paola, MOK, Wilson, ALEXANDRAKIS, George, INSIN, Numpon, ZIMMER, John P, BAWENDI, Moungi G, BOUCHER, Yves, BREAKEFIELD, Xandra O, JAIN, Rakesh K

“…Oncolytic viral therapy provides a promising approach to treat certain human malignancies. These vectors improve on replication-deficient vectors by increasing…”
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Imaging flow cytometry facilitates multiparametric characterization of extracellular vesicles in malignant brain tumours by Ricklefs, Franz L., Maire, Cecile L., Reimer, Rudolph, Dührsen, Lasse, Kolbe, Katharina, Holz, Mareike, Schneider, Enja, Rissiek, Anne, Babayan, Anna, Hille, Claudia, Pantel, Klaus, Krasemann, Susanne, Glatzel, Markus, Heiland, Dieter Henrik, Flitsch, Jörg, Martens, Tobias, Schmidt, Nils Ole, Peine, Sven, Breakefield, Xandra O., Lawler, Sean, Chiocca, E. Antonio, Fehse, Boris, Giebel, Bernd, Görgens, André, Westphal, Manfred, Lamszus, Katrin

“…Cells release heterogeneous nano-sized vesicles either as exosomes, being derived from endosomal compartments, or through budding from the plasma membrane as…”
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Molecular imaging of gene therapy for cancer by SHAH, K, JACOBS, A, BREAKEFIELD, X. O, WEISSLEDER, R

“…Gene therapy of cancer has been one of the most exciting and elusive areas of scientific and clinical research in the past decade. One of the most critical…”
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TorsinA and heat shock proteins act as molecular chaperones: suppression of α‐synuclein aggregation by McLean, Pamela J., Kawamata, Hibiki, Shariff, Saadat, Hewett, Jeffrey, Sharma, Nutan, Ueda, Kenji, Breakefield, Xandra O., Hyman, Bradley T.

“…TorsinA, a protein with homology to yeast heat shock protein104, has previously been demonstrated to colocalize with α‐synuclein in Lewy bodies, the…”
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Glioma therapy and real-time imaging of neural precursor cell migration and tumor regression by Shah, Khalid, Bureau, Emilie, Kim, Dong-Eog, Yang, Katherine, Tang, Yi, Weissleder, Ralph, Breakefield, Xandra O.

“…Despite many refinements in current therapeutic strategies, the overall prognosis for a patient with glioblastoma is dismal. Neural precursor cells (NPCs) are…”
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TorsinA in the Nuclear Envelope by Naismith, Teresa V., Heuser, John E., Breakefield, Xandra O., Hanson, Phyllis I., De Camilli, Pietro V.

“…Early-onset torsion dystonia, a CNS-based movement disorder, is usually associated with a single amino acid deletion (ΔE302/303) in the protein torsinA…”
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Neural Stem Cells Display Extensive Tropism for Pathology in Adult Brain: Evidence from Intracranial Gliomas by Aboody, Karen S., Brown, Alice, Rainov, Nikolai G., Bower, Kate A., Liu, Shaoxiong, Yang, Wendy, Small, Juan E., Herrlinger, Ulrich, Ourednik, Vaclav, Peter Mc L. Black, Breakefield, Xandra O., Snyder, Evan Y.

“…One of the impediments to the treatment of brain tumors (e.g., gliomas) has been the degree to which they expand, infiltrate surrounding tissue, and migrate…”
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FGF-2 Regulation of Neurogenesis in Adult Hippocampus after Brain Injury by Yoshimura, Shinichi, Takagi, Yasushi, Harada, Jun, Teramoto, Tetsuyuki, Thomas, Sunu S., Waeber, Christian, Bakowska, Joanna C., Breakefield, Xandra O., Moskowitz, Michael A.

“…Fibroblast growth factor-2 (FGF-2) promotes proliferation of neuroprogenitor cells in culture and is up-regulated within brain after injury. Using mice…”
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In vivo imaging of S-TRAIL-mediated tumor regression and apoptosis by Shah, Khalid, Tung, Ching-Hsuan, Breakefield, Xandra O, Weissleder, Ralph

“…Therapeutic proteins with specific effector functions play an increasingly important role in drug therapy. For example, tumor necrosis factor-related…”
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Impaired Motor Learning in Mice Expressing TorsinA with the DYT1 Dystonia Mutation by Sharma, Nutan, Baxter, Mark G, Petravicz, Jeremy, Bragg, D. Cristopher, Schienda, Alonna, Standaert, David G, Breakefield, Xandra O

“…Primary early-onset generalized dystonia is an autosomal dominant disorder caused by a deletion (DeltaGAG) in the DYT1 gene encoding torsinA. The gene defect…”
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Metabolic biotinylation of cell surface receptors for in vivo imaging by Weissleder, Ralph, Tannous, Bakhos A, Grimm, Jan, Perry, Katherine F, Chen, John W, Breakefield, Xandra O

“…We have developed a versatile, potent technique for imaging cells in culture and in vivo by expressing a metabolically biotinylated cell-surface receptor and…”
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FGF-2 regulates neurogenesis and degeneration in the dentate gyrus after traumatic brain injury in mice by Yoshimura, S, Teramoto, T, Whalen, MJ, Irizarry, M C, Takagi, Y, Qiu, J, Harada, J, Waeber, C, Breakefield, X O, Moskowitz, MA

“…We studied the role of FGF-2 on regulation of neurogenesis and cell loss in the granule cell layer (GCL) of the hippocampal dentate gyrus after experimental…”
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Dystonia-causing mutant torsinA inhibits cell adhesion and neurite extension through interference with cytoskeletal dynamics by Hewett, Jeffrey W., Zeng, Juan, Niland, Brian P., Bragg, D. Cristopher, Breakefield, Xandra O.

“…Early onset torsion dystonia is a movement disorder inherited as an autosomal dominant syndrome with reduced penetrance. Symptoms appear to result from altered…”
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Effects of genetic variations in the dystonia protein torsinA: identification of polymorphism at residue 216 as protein modifier by Kock, Norman, Naismith, Teresa V., Boston, Heather E., Ozelius, Laurie J., Corey, David P., Breakefield, Xandra O., Hanson, Phyllis I.

“…Four naturally occurring sequence variations have been found in the coding region of the DYT1 gene encoding torsinA. One of these, a 3 bp (ΔGAG) deletion,…”
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TorsinA: Movement at Many Levels by Breakefield, Xandra O., Kamm, Christoph, Hanson, Phyllis I.

“…TorsinA is the causative protein in the human neurologic disease early onset torsin dystonia, a movement disorder involving dysfunction in the basal ganglia…”
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Intravascular delivery of neural stem cell lines to target intracranial and extracranial tumors of neural and non-neural origin by Brown, Alice B, Yang, Wendy, Schmidt, Nils O, Carroll, Rona, Leishear, Kim K, Rainov, Nikolai G, Black, Peter M, Breakefield, Xandra O, Aboody, Karen S

“…The remarkable migratory and tumor-tropic capacities of neural stem cells (NSCs and/or neuroprogenitor cells) represent a potentially powerful approach to the…”
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Update on Herpesvirus Amplicon Vectors by Oehmig, Angelika, Fraefel, Cornel, Breakefield, Xandra O

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