Search Results - "Brea, Elliott"

Structure of a TCR-Mimic Antibody with Target Predicts Pharmacogenetics by Ataie, Niloufar, Xiang, Jingyi, Cheng, Neal, Brea, Elliott J., Lu, Wenjie, Scheinberg, David A., Liu, Cheng, Ng, Ho Leung

“…Antibody therapies currently target only extracellular antigens. A strategy to recognize intracellular antigens is to target peptides presented by immune HLA…”
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Pulsatile MEK Inhibition Improves Anti-tumor Immunity and T Cell Function in Murine Kras Mutant Lung Cancer by Choi, Hyejin, Deng, Jiehui, Li, Shuai, Silk, Tarik, Dong, Lauren, Brea, Elliott J., Houghton, Sean, Redmond, David, Zhong, Hong, Boiarsky, Jonathan, Akbay, Esra A., Smith, Paul D., Merghoub, Taha, Wong, Kwok-Kin, Wolchok, Jedd D.

“…KRAS is one of the driver oncogenes in non-small-cell lung cancer (NSCLC) but remains refractory to current modalities of targeted pathway inhibition, which…”
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Kinase Regulation of Human MHC Class I Molecule Expression on Cancer Cells by Brea, Elliott J, Oh, Claire Y, Manchado, Eusebio, Budhu, Sadna, Gejman, Ron S, Mo, George, Mondello, Patrizia, Han, James E, Jarvis, Casey A, Ulmert, David, Xiang, Qing, Chang, Aaron Y, Garippa, Ralph J, Merghoub, Taha, Wolchok, Jedd D, Rosen, Neal, Lowe, Scott W, Scheinberg, David A

“…The major histocompatibility complex I (MHC-1) presents antigenic peptides to tumor-specific CD8 T cells. The regulation of MHC-I by kinases is largely…”
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Deconvoluting hepatic processing of carbon nanotubes by Alidori, Simone, Bowman, Robert L., Yarilin, Dmitry, Romin, Yevgeniy, Barlas, Afsar, Mulvey, J. Justin, Fujisawa, Sho, Xu, Ke, Ruggiero, Alessandro, Riabov, Vladimir, Thorek, Daniel L. J., Ulmert, Hans David S., Brea, Elliott J., Behling, Katja, Kzhyshkowska, Julia, Manova-Todorova, Katia, Scheinberg, David A., McDevitt, Michael R.

“…Single-wall carbon nanotubes present unique opportunities for drug delivery, but have not advanced into the clinic. Differential nanotube accretion and…”
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A comprehensive review of DOACs for cancer associated VTE prophylaxis or treatment by Brea, Elliott J., Tiu, Bruce C., Connors, Jean M.

“…Cancer is a leading cause of venous thromboembolism (VTE), which contributes to significant morbidity and mortality in these patients. Increased thrombotic…”
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Dual inhibition of histone deacetylases and phosphoinositide 3-kinase enhances therapeutic activity against B cell lymphoma by Mondello, Patrizia, Derenzini, Enrico, Asgari, Zahra, Philip, John, Brea, Elliott J, Seshan, Venkatraman, Hendrickson, Ronald C, de Stanchina, Elisa, Scheinberg, David A, Younes, Anas

“…Phosphoinositide 3-kinase (PI3K) and Myc are known to cooperate in promoting the survival and growth of a variety of B-cell lymphomas. While currently there…”
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ALK and RET Inhibitors Promote HLA Class I Antigen Presentation and Unmask New Antigens within the Tumor Immunopeptidome by Oh, Claire Y, Klatt, Martin G, Bourne, Christopher, Dao, Tao, Dacek, Megan M, Brea, Elliott J, Mun, Sung Soo, Chang, Aaron Y, Korontsvit, Tatyana, Scheinberg, David A

“…T-cell immunotherapies are often thwarted by the limited presentation of tumor-specific antigens abetted by the downregulation of human leukocyte antigen…”
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Solid-state NMR analysis of membrane proteins and protein aggregates by proton detected spectroscopy by Zhou, Donghua H., Nieuwkoop, Andrew J., Berthold, Deborah A., Comellas, Gemma, Sperling, Lindsay J., Tang, Ming, Shah, Gautam J., Brea, Elliott J., Lemkau, Luisel R., Rienstra, Chad M.

“…Solid-state NMR has emerged as an important tool for structural biology and chemistry, capable of solving atomic-resolution structures for proteins in…”
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Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy by Miller, Peter G., Sperling, Adam S., Brea, Elliott J., Leick, Mark B., Fell, Geoffrey G., Jan, Max, Gohil, Satyen H., Tai, Yu-Tzu, Munshi, Nikhil C., Wu, Catherine J., Neuberg, Donna S., Maus, Marcela V., Jacobson, Caron, Gibson, Christopher J., Ebert, Benjamin L.

“…Chimeric antigen receptor (CAR) T-cells have emerged as an efficacious modality in patients with non-Hodgkin lymphoma (NHL) and multiple myeloma (MM). Clonal…”
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Depleting T regulatory cells by targeting intracellular Foxp3 with a TCR mimic antibody by Dao, Tao, Mun, Sung Soo, Scott, Andrew C., Jarvis, Casey A., Korontsvit, Tatyana, Yang, Zhiyuan, Liu, Lianxing, Klatt, Martin G., Guerreiro, Manuel, Selvakumar, Annamalai, Brea, Elliott J., Oh, Claire, Liu, Cheng, Scheinberg, David A.

“…Depletion of T regulatory cells (Tregs) in the tumor microenvironment is a promising cancer immunotherapy strategy. Current approaches for depleting Tregs are…”
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Abstract 4899: The regulation by kinases of the expression of human major histocompatibility class I molecules by Brea, Elliott J., Oh, Claire, Manchado, Eusebio, Gejman, Ron, Mo, George, Mondello, Patrizia, Garippa, Ralph, Rosen, Neal, Scheinberg, David A.

“…Abstract The major histocompatability complex (MHC) is a central receptor in the adaptive immune response and is the underlying target of several effective…”
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T cell receptor mimic antibodies for cancer therapy by Dubrovsky, Leonid, Dao, Tao, Gejman, Ron S, Brea, Elliott J, Chang, Aaron Y, Oh, Claire Y, Casey, Emily, Pankov, Dmitry, Scheinberg, David A

“…The major hurdle to the creation of cancer-specific monoclonal antibodies (mAb) exhibiting limited cross-reactivity with healthy human cells is the paucity of…”
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Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265P mutations by Mondello, Patrizia, Brea, Elliott J, De Stanchina, Elisa, Toska, Eneda, Chang, Aaron Y, Fennell, Myles, Seshan, Venkatraman, Garippa, Ralph, Scheinberg, David A, Baselga, José, Wendel, Hans-Guido, Younes, Anas

“…Diffuse large B cell lymphoma (DLBCL) frequently harbors genetic alterations that activate the B cell receptor (BCR) and TLR pathways, which converge to…”
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Opportunities and challenges for TCR mimic antibodies in cancer therapy by Chang, Aaron Y, Gejman, Ron S, Brea, Elliott J, Oh, Claire Y, Mathias, Melissa D, Pankov, Dmitry, Casey, Emily, Dao, Tao, Scheinberg, David A

“…Monoclonal antibodies (mAbs) are potent cancer therapeutic agents, but exclusively recognize cell-surface targets whereas most cancer-associated proteins are…”
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Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265P mutations by Mondello, Patrizia, Brea, Elliott J, De Stanchina, Elisa, Toska, Eneda, Chang, Aaron Y, Fennell, Myles, Seshan, Venkatraman, Garippa, Ralph, Scheinberg, David A, Baselga, José, Wendel, Hans-Guido, Younes, Anas

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Targeted Therapy for Non–Small Cell Lung Cancer by Brea, Elliott, Rotow, Julia

“…This article provides an updated review of the management of oncogene-driven non–small cell lung cancer. The use of targeted therapies for lung cancer driven…”
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Targeted Therapy for Non-Small Cell Lung Cancer: First Line and Beyond by Brea, Elliott, Rotow, Julia

“…This article provides an updated review of the management of oncogene-driven non-small cell lung cancer. The use of targeted therapies for lung cancer driven…”
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Abstract 923: Pulsatile MEK inhibition improves anti-tumor immunity and T cell function in Kras mutant lung cancer by Choi, Hyejin, Deng, Jiehui, Li, Shuai, Silk, Tarik, Dong, Lauren, Brea, Elliott J., Houghton, Sean, Redmond, David, Zhong, Hong, Boiarsky, Jonathan, Akbay, Esra A., Smith, Paul D., Merghoub, Taha, Wong, Kwok-Kin, Wolchok, Jedd D.

“…Abstract KRAS is one of the most commonly identified driver oncogenes in non-small cell lung cancer (NSCLC) and is frequently associated with disease…”
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A TCR-mimic antibody to WT1 bypasses tyrosine kinase inhibitor resistance in human BCR-ABL+ leukemias by Dubrovsky, Leonid, Pankov, Dmitry, Brea, Elliott Joseph, Dao, Tao, Scott, Andrew, Yan, Su, O'Reilly, Richard J, Liu, Cheng, Scheinberg, David A.

“…Acute and chronic leukemias, including CD34+ CML cells, demonstrate increased expression of the Wilms tumor gene 1 product (WT1), making WT1 an attractive…”
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Panobinostat acts synergistically with ibrutinib in diffuse large B cell lymphoma cells with MyD88 L265 mutations by Mondello, Patrizia, Brea, Elliott J., De Stanchina, Elisa, Toska, Eneda, Chang, Aaron Y., Fennell, Myles, Seshan, Venkatraman, Garippa, Ralph, Scheinberg, David A., Baselga, José, Wendel, Hans-Guido, Younes, Anas

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