Search Results - "Brazzell, R K"

Periocular Injection of Microspheres Containing PKC412 Inhibits Choroidal Neovascularization in a Porcine Model by Saishin, Yoshitsugu, Silva, Raquel Lima, Saishin, Yumiko, Callahan, Kevin, Schoch, Christian, Ahlheim, Markus, Lai, Hong, Kane, Frances, Brazzell, R. K, Bodmer, David, Campochiaro, Peter A

“…Oral administration of PKC412, a kinase inhibitor that blocks several isoforms of protein kinase C (PKC) and receptors for vascular endothelial growth factor…”
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Sustained transduction of ocular cells with a bovine immunodeficiency viral vector by Takahashi, Kyoichi, Luo, Tianci, Saishin, Yoshitsugu, Saishin, Yumiko, Sung, Jennifer, Hackett, Sean, Brazzell, R K, Kaleko, Michael, Campochiaro, Peter A

“…Human immunodeficiency viral (HIV) vectors mediate long-term transduction of many types of nondividing cells in vivo. Bovine immunodeficiency virus (BIV) is a…”
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Human recombinant epidermal growth factor in experimental corneal wound healing by Brazzell, RK, Stern, ME, Aquavella, JV, Beuerman, RW, Baird, L

“…Human recombinant epidermal growth factor (hEGF) was evaluated in various corneal wound healing models in the rabbit. Human EGF accelerated epithelial wound…”
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Interspecies comparison of the pharmacokinetics of aldose reductase inhibitors by Brazzell, R K, Park, Y H, Wooldridge, C B, McCue, B, Barker, R, Couch, R, York, B

“…The pharmacokinetics of three aldose reductase inhibitors (ARIs) were evaluated in various species, including rat, dog, cynomolgus monkey, rhesus monkey,…”
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Pharmacokinetics of isotretinoin during repetitive dosing to patients by Brazzell, R K, Vane, F M, Ehmann, C W, Colburn, W A

“…The multiple dose pharmacokinetics of isotretinoin and its major blood metabolite, 4-oxo-isotretinoin, were studied in 10 patients with cystic acne and 11…”
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Application of statistical moment theory to pharmacokinetics by Mayer, P R, Brazzell, R K

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Disposition of the aldose reductase inhibitor AL01576 in rats by Park, Y H, Wooldridge, C B, Mattern, J, Stoltz, M L, Brazzell, R K

“…The disposition of the aldose reductase inhibitor AL01576 was studied in rats following intravenous and oral dosing. Single 4-mg/kg intravenous bolus and oral…”
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Comparison of statistical moment parameters to Cmax and tmax for detecting differences in in vivo dissolution rates by Khoo, K C, Gibaldi, M, Brazzell, R K

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Saturable tissue binding and imirestat pharmacokinetics in rats by CHIEN, J. Y, BANFIELD, C. R, BRAZZELL, R. K, MAYER, P. R, SLATTERY, J. T

“…To investigate the hypothesis that the pharmacokinetics of imirestat, an aldose reductase inhibitor, are influenced by saturable binding to tissues, three…”
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Age and cibenzoline disposition by Brazzell, R K, Rees, M M, Khoo, K C, Szuna, A J, Sandor, D, Hannigan, J

“…Oral cibenzoline kinetics were followed in 36 healthy subjects aged from 22 to 78 yr divided into groups of six subjects per decade between 20 and 80 yr. Each…”
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Single-dose pharmacokinetics and dose proportionality of oral cibenzoline by Khoo, K C, Szuna, A J, Colburn, W A, Aogaichi, K, Morganroth, J, Brazzell, R K

“…The pharmacokinetics of cibenzoline were evaluated in four young healthy volunteers who received ascending oral doses of 65, 97.5, 130, 162.5, 195, 227.5, and…”
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Dose-dependent pharmacokinetics of the aldose reductase inhibitor imirestat in man by BRAZZELL, R. K, MAYER, P. R, DOBBS, R, MCNAMARA, P. J, RENLI TENG, SLATTERY, J. T

“…The pharmacokinetics of imirestat were studied in healthy volunteers following single and multiple oral doses. After single doses of 20 to 50 mg, imirestat…”
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Pharmacokinetics of the aldose reductase inhibitor imirestat following topical ocular administration by BRAZZELL, R. K, WOOLDRIDGE, C. B, HACKETT, R. B, MCCUE, B. A

“…The pharmacokinetics of imirestat following topical ocular administration were evaluated in a series of studies in rabbits and dogs. Following single topical…”
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Serum protein binding of AL01576, a new aldose reductase inhibitor by McNamara, P J, Blouin, R A, Brazzell, R K

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Pharmacokinetics and pharmacodynamics of intravenous cibenzoline in normal volunteers by Brazzell, R K, Khoo, K C, Szuna, A J, Sandor, D, Aogaichi, K, Wills, R J

“…The pharmacokinetics of intravenous (IV) cibenzoline were studied in six healthy male volunteers ranging in age from 51 to 78 years. The subjects received…”
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Topical and systemic absorption of sodium pyrithione following topical application to the nails of the rhesus monkey by Mayer, P R, Couch, R C, Erickson, M K, Wooldridge, C B, Brazzell, R K

“…A study was performed to investigate the local penetration into the nail, the systemic absorption into the rest of the body, and the routes of excretion of…”
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Cibenzoline plasma concentration and antiarrhythmic effect by Brazzell, R K, Aogaichi, K, Heger, Jr, J J, Somberg, J C, Carliner, N H, Morganroth, J

“…The relationship between plasma concentrations of cibenzoline and its antiarrhythmic effect was evaluated in patients receiving the drug orally as part of an…”
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Effect of time of dosing on the disposition of oral cibenzoline by Brazzell, R K, Khoo, K C, Schneck, D W

“…Single oral doses of cibenzoline were administered to eight healthy volunteers on two different occasions, once at 8.00 am and once at 10.00 pm, in a…”
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Pharmacokinetic and pharmacodynamic modeling of cibenzoline plasma concentrations and antiarrhythmic effect by Holazo, A A, Brazzell, R K, Colburn, W A

“…The plasma concentration and antiarrhythmic effect data following multiple, ascending oral doses of cibenzoline in four patients with frequent premature…”
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Verapamil pharmacodynamics after intravenous and oral dosing: theoretic consideration by Colburn, W A, Brazzell, R K, Holazo, A A

“…Differences in the potency of intravenous (IV) and oral verapamil have recently been reported with the concentration-response curve for PR-interval…”
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