Search Results - "Brazil, Derek P."

Diabetic Nephropathy: a Tangled Web to Unweave by Magee, Corey, Grieve, David J., Watson, Chris J., Brazil, Derek P.

“…Diabetic nephropathy (DN) is currently the leading cause of end-stage renal disease globally. Given the increasing incidence of diabetes, many experts hold the…”
Get full text

Gremlin1 preferentially binds to bone morphogenetic protein-2 (BMP-2) and BMP-4 over BMP-7 by Church, Rachel H, Krishnakumar, Arjun, Urbanek, Annika, Geschwindner, Stefan, Meneely, Julie, Bianchi, Alessandro, Basta, Barbro, Monaghan, Sean, Elliot, Christopher, Strömstedt, Maria, Ferguson, Neil, Martin, Finian, Brazil, Derek P

“…Gremlin (Grem1) is a member of the DAN family of secreted bone morphogenetic protein (BMP) antagonists. Bone morphogenetic protein-7 (BMP-7) mediates…”
Get more information

Cyclic Adenosine Monophosphate-Response Element–Binding Protein Mediates the Proangiogenic or Proinflammatory Activity of Gremlin by Corsini, Michela, Moroni, Emanuela, Ravelli, Cosetta, Andrés, Germán, Grillo, Elisabetta, Ali, Imran H, Brazil, Derek P, Presta, Marco, Mitola, Stefania

“…OBJECTIVE—Angiogenesis and inflammation are closely related processes. Gremlin is a novel noncanonical vascular endothelial growth factor receptor-2 (VEGFR2)…”
Get full text

Uncoupled turnover disrupts mitochondrial quality control in diabetic retinopathy by Hombrebueno, Jose R, Cairns, Lauren, Dutton, Louise R, Lyons, Timothy J, Brazil, Derek P, Moynagh, Paul, Curtis, Tim M, Xu, Heping

“…Mitochondrial quality control (MQC) is crucial for regulating CNS homeostasis, and its disruption has been implicated in the pathogenesis of some of the most…”
Get full text

Stabilization of Mdm2 via Decreased Ubiquitination Is Mediated by Protein Kinase B/Akt-dependent Phosphorylation by Feng, Jianhua, Tamaskovic, Rastislav, Yang, Zhongzhou, Brazil, Derek P, Merlo, Adrian, Hess, Daniel, Hemmings, Brian A

“…The tumor suppressor p53 is commonly inhibited under conditions in which the phosphatidylinositide 3′-OH kinase/protein kinase B (PKB)Akt pathway is…”
Get full text

Selective inhibition of retinal angiogenesis by targeting PI3 kinase by Alvarez, Yolanda, Astudillo, Olaya, Jensen, Lasse, Reynolds, Alison L, Waghorne, Nora, Brazil, Derek P, Cao, Yihai, O'Connor, John J, Kennedy, Breandán N

“…Ocular neovascularisation is a pathological hallmark of some forms of debilitating blindness including diabetic retinopathy, age related macular degeneration…”
Get full text

Next-generation sequencing identifies TGF-β1-associated gene expression profiles in renal epithelial cells reiterated in human diabetic nephropathy by Brennan, Eoin P., Morine, Melissa J., Walsh, David W., Roxburgh, Sarah A., Lindenmeyer, Maja T., Brazil, Derek P., Gaora, Peadar Ó., Roche, Helen M., Sadlier, Denise M., Cohen, Clemens D., Godson, Catherine, Martin, Finian

“…Transforming growth factor-beta (TGF-β1) is implicated in the onset and progression of renal fibrosis and diabetic nephropathy (DN), leading to a loss of…”
Get full text

Insulin Receptor Substrate-2 Deficiency Impairs Brain Growth and Promotes Tau Phosphorylation by Schubert, Markus, Brazil, Derek P, Burks, Deborah J, Kushner, Jake A, Ye, Jing, Flint, Carrie L, Farhang-Fallah, Janet, Dikkes, Pieter, Warot, Xavier M, Rio, Carlos, Corfas, Gabriel, White, Morris F

“…Insulin resistance and diabetes might promote neurodegenerative disease, but a molecular link between these disorders is unknown. Many factors are responsible…”
Get full text

Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease by Roxburgh, Sarah A., Kattla, Jayesh J., Curran, Simon P., O'Meara, Yvonne M., Pollock, Carol A., Goldschmeding, Roel, Godson, Catherine, Martin, Finian, Brazil, Derek P.

“…Allelic Depletion of grem1 Attenuates Diabetic Kidney Disease Sarah A. Roxburgh 1 , Jayesh J. Kattla 1 , Simon P. Curran 1 , Yvonne M. O'Meara 1 , 2 , Carol A…”
Get full text

Effects of modified lipoproteins on human trophoblast cells: a role in pre-eclampsia in pregnancies complicated by diabetes by McLeese, Rebecca Helen, Zhao, Jiawu, Fu, Dongxu, Yu, Jeremy Y, Brazil, Derek P, Lyons, Timothy J

“…IntroductionPre-eclampsia (PE) is increased ~4-fold by maternal diabetes. Elevated plasma antiangiogenic factors, soluble fms-like tyrosine kinase (sFLT-1) and…”
Get full text

DNA-dependent Protein Kinase-mediated Phosphorylation of Protein Kinase B Requires a Specific Recognition Sequence in the C-terminal Hydrophobic Motif by Park, Jongsun, Feng, Jianhua, Li, Yuwen, Hammarsten, Ola, Brazil, Derek P., Hemmings, Brian A.

“…DNA-dependent protein kinase (DNA-PK) has been implicated in a variety of nuclear processes including DNA double strand break repair, V(D)J recombination, and…”
Get full text

Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids by Davis, Jessica L., Kennedy, Ciaran, Clerkin, Shane, Treacy, Niall J., Dodd, Thomas, Moss, Catherine, Murphy, Alison, Brazil, Derek P., Cagney, Gerard, Brougham, Dermot F., Murad, Rabi, Finlay, Darren, Vuori, Kristiina, Crean, John

“…TGFβ1 plays a regulatory role in the determination of renal cell fate and the progression of renal fibrosis. Here we show an association between SMAD3 and the…”
Get full text

BMP signalling: agony and antagony in the family by Brazil, Derek P, Church, Rachel H, Surae, Satnam, Godson, Catherine, Martin, Finian

“…Bone morphogenetic proteins (BMPs) are secreted extracellular matrix (ECM)-associated proteins that regulate a wide range of developmental processes, including…”
Get full text

Loss of TRPV2-mediated blood flow autoregulation recapitulates diabetic retinopathy in rats by O'Hare, Michael, Esquiva, Gema, McGahon, Mary K, Hombrebueno, Jose Manuel Romero, Augustine, Josy, Canning, Paul, Edgar, Kevin S, Barabas, Peter, Friedel, Thomas, Cincolà, Patrizia, Henry, Jennifer, Mayne, Katie, Ferrin, Hannah, Stitt, Alan W, Lyons, Timothy J, Brazil, Derek P, Grieve, David J, McGeown, J Graham, Curtis, Tim M

“…Loss of retinal blood flow autoregulation is an early feature of diabetes that precedes the development of clinically recognizable diabetic retinopathy (DR)…”
Get full text

Maternal and fetal placental growth hormone and IGF axis in type 1 diabetic pregnancy by Higgins, Mary F, Russell, Noirin E, Crossey, Paul A, Nyhan, Kristine C, Brazil, Derek P, McAuliffe, Fionnuala M

“…Placental growth hormone (PGH) is a major growth hormone in pregnancy and acts with Insulin Like Growth Factor I (IGF-I) and Insulin Like Growth Hormone…”
Get full text

Connective tissue growth factor antagonizes transforming growth factor-β1/Smad signalling in renal mesangial cells by O'Donovan, Helen C, Hickey, Fionnuala, Brazil, Derek P, Kavanagh, David H, Oliver, Noelynn, Martin, Finian, Godson, Catherine, Crean, John

“…The critical involvement of TGF-β1 (transforming growth factor-β1) in DN (diabetic nephropathy) is well established. However, the role of CTGF (connective…”
Get more information

PLAC8-Mediated Activation of NOX4 Signalling Restores Angiogenic Function of Endothelial Colony-Forming Cells in Experimental Hypoxia by Pun, Shun Hay, O'Neill, Karla M, Edgar, Kevin S, Gill, Eleanor K, Moez, Arya, Naderi-Meshkin, Hojjat, Malla, Sudhir B, Hookham, Michelle B, Alsaggaf, Mohammed, Madishetti, Vinuthna Vani, Botezatu, Bianca, King, William, Brunssen, Coy, Morawietz, Henning, Dunne, Philip D, Brazil, Derek P, Medina, Reinhold J, Watson, Chris J, Grieve, David J

“…Ischaemic cardiovascular disease is associated with tissue hypoxia as a significant determinant of angiogenic dysfunction and adverse remodelling. While cord…”
Get full text

Association of LETM1 and MRPL36 Contributes to the Regulation of Mitochondrial ATP Production and Necrotic Cell Death by LONGZHEN PIAO, YUWEN LI, GANG MIN HUR, JEONG HO SEOK, SHONG, Minho, CHO, Myung-Haing, BRAZIL, Derek P, HEMMINGS, Brian A, PARK, Jongsun, SOUNG JUNG KIM, HEE SUN BYUN, SONG MEI HUANG, HWANG, Soon-Kyung, YANG, Keum-Jin, KYEONG AH PARK, WON, Minho, HOG, Janghee

“…Leucine zipper/EF hand-containing transmembrane-1 (LETM1) is a mitochondrial inner membrane protein that was first identified in Wolf-Hirschhorn syndrome, and…”
Get full text

Insulin receptor substrate‐2 is expressed in kidney epithelium and up‐regulated in diabetic nephropathy by Hookham, Michelle B., O'Donovan, Helen C., Church, Rachel H., Mercier‐Zuber, Annie, Luzi, Lucilla, Curran, Simon P., Carew, Rosemarie M., Droguett, Alejandra, Mezzano, Sergio, Schubert, Markus, White, Morris F., Crean, John K., Brazil, Derek P.

“…Diabetic nephropathy (DN) is a progressive fibrotic condition that may lead to end‐stage renal disease and kidney failure. Transforming growth factor‐β1 and…”
Get full text

IRS proteins and diabetic complications by Lavin, Deborah P., White, Morris F., Brazil, Derek P.

“…IRS proteins are cellular adaptor molecules that mediate many of the key metabolic actions of insulin. When tyrosine is phosphorylated by the activated insulin…”
Get full text