Search Results - "Brazell, C."

Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice by Waider, J, Popp, S, Lange, M D, Kern, R, Kolter, J F, Kobler, J, Donner, N C, Lowe, K R, Malzbender, J H, Brazell, C J, Arnold, M R, Aboagye, B, Schmitt-Böhrer, A, Lowry, C A, Pape, H C, Lesch, K P

“…Multiple lines of evidence implicate brain serotonin (5-hydroxytryptamine; 5-HT) system dysfunction in the pathophysiology of stressor-related and anxiety…”
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Maximizing the value of medicines by including pharmacogenetic research in drug development and surveillance by Brazell, C., Freeman, A., Mosteller, M.

“…Genetics provides significant opportunities to maximize the safety and efficacy of medicines. Over the next 3–5 years, it may be possible to develop tools that…”
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Elements of informed consent for pharmacogenetic research; perspective of the pharmacogenetics working group by ANDERSON, D. C, GOMEZ-MANCILLA, B, MCHALE, D, HASHIMOTO, L, SANDBRINK, R, WATSON, M. L, SALERNO, R. A, COHEN, N, LISTER, C. E, SPEAR, B. B, BARNES, D. M, CHEESEMAN, K, SHAW, P. M, FRIEDMAN, J, MCCARTHY, A, BRAZELL, C, RAY, S. C

“…THE PHARMACOGENOMICS JOURNAL: (2002) 2, 284-292. doi:10.1038/sj.tpj.6500131…”
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The neuroprotective action of dizocilpine (MK‐801) in the rat middle cerebral artery occlusion model of focal ischaemia by Gill, R., Brazell, C., Woodruff, G.N., Kemp, J.A.

“…1 An acute model of focal ischaemia, which involves permanent occlusion of the middle cerebral artery of the rat with 4 h survival, was used to find the…”
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Pharmacogenomics and regulatory decision making: an international perspective by Mendrick, D L, Brazell, C, Mansfield, E A, Pietrusko, R, Barilero, I, Hackett, J, Stürzebecher, S, Jacobson-Kram, D

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MK-212 increases rat plasma ACTH concentration by activation of the 5-HT1C receptor subtype by King, B H, Brazell, C, Dourish, C T, Middlemiss, D N

“…The effects of the serotonin agonist MK-212, on rat plasma ACTH were examined. MK-212 significantly increased plasma ACTH levels, and this effect was blocked…”
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Reversal of cognitive impairment by heptyl physostigmine, a long-lasting cholinesterase inhibitor, in primates by Rupniak, N M, Tye, S J, Brazell, C, Heald, A, Iversen, S D, Pagella, P G

“…Cholinergic replacement therapy for Alzheimer's disease using existing cholinesterase inhibitors is compromised by short duration, meagre benefits restricted…”
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Relationship of increased food intake and plasma ACTH levels to 5-HT1A receptor activation in rats by Gilbert, F, Dourish, C T, Brazell, C, McClue, S, Stahl, S M

“…Various putative agonists of the 5-HT1A receptor subtype induce feeding in rats, probably by activating raphé somatodendritic 5-HT autoreceptors. These drugs…”
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Administration of aerosol pentamidine: a program design by O'Hara, C M, Anton, W R, Gormley, F X, Brazell, C

“…Aerosol pentamidine (AP) is an FDA-approved prophylaxis against pneumocystis carinii pneumonia (PCP) in HIV-infected individuals who have a CD4+ lymphocyte…”
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Pharmacogenetics and Pharmacogenomics in Drug Development and Regulatory Decision Making: Report of the First FDA-PWG-PhRMA-DruSafe Workshop by Lesko, Lawrence J., Salerno, Ronald A., Spear, Brian B., Anderson, Donald C., Anderson, Timothy, Brazell, Celia, Collins, Jerry, Dorner, Andrew, Essayan, David, Gomez-Mancilla, Baltazar, Hackett, Joseph, Huang, Shiew-Mei, Ide, Susan, Killinger, Joanne, Leighton, John, Mansfield, Elizabeth, Meyer, Robert, Ryan, Stephen G., Schmith, Virginia, Shaw, Peter, Sistare, Frank, Watson, Mark, Worobec, Alexandra

“…The use of pharmacogenetics and pharmacogenomics in the drug development process, and in the assessment of such data submitted to regulatory agencies by…”
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RETURNING GENETIC RESEARCH RESULTS TO INDIVIDUALS: POINTS-TO-CONSIDER by RENEGAR, GAILE, WEBSTER, CHRISTOPHER J., STUERZEBECHER, STEFFEN, HARTY, LEA, IDE, SUSAN E., BALKITE, BETH, ROGALSKI-SALTER, TARYN A., COHEN, NADINE, SPEAR, BRIAN B., BARNES, DIANE M., BRAZELL, CELIA

“…ABSTRACT This paper is intended to stimulate debate amongst stakeholders in the international research community on the topic of returning individual genetic…”
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5-Hydroxytryptamine (5-HT)-induced shape change in human platelets determined by computerized data acquisition: correlation with [125I]-iodoLSD binding at 5-HT2 receptors by Brazell, C, McClue, S J, Preston, G C, King, B, Stahl, S M

“…The 5-HT-induced shape change and subsequent aggregation of platelets provides a functional assay for 5-HT2 receptors. In the present study we describe a…”
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Pharmacogenetics in drug development: Regulatory and clinical considerations by Hall, Susan T., Abbott, Neil, Schmith, Ginny, Brazell, Celia

“…Pharmacogenetics (the study of inter‐individual inherited variations in DNA sequence related to drug response) is increasingly gaining recognition as an…”
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Activation of the 5-HT1A receptor subtype increases rat plasma ACTH concentration by Gilbert, F, Brazell, C, Tricklebank, M D, Stahl, S M

“…Serotonergic (5-HT) neuronal pathways regulate the release of adrenocorticotropin hormone (ACTH) from the pituitary gland probably through the action of…”
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The dose-response relationship and therapeutic window for dizocilpine (MK-801) in a rat focal ischaemia model by Hatfield, R H, Gill, R, Brazell, C

“…The purpose of the present study was to examine the dose-response relationship and the maximum time for which effective therapy could be delayed for the…”
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Plasma and CSF levels of dizocilpine (MK-801) required for neuroprotection in the quinolinate-injected rat striatum by Willis, C L, Brazell, C, Foster, A C

“…This study has identified the range of plasma and cerebrospinal fluid (CSF) concentrations of the uncompetitive N-methyl-D-aspartate receptor antagonist…”
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Hallucinogenic drugs are partial agonists of the human platelet shape change response: a physiological model of the 5-HT2 receptor by McClue, S J, Brazell, C, Stahl, S M

“…We have assayed several phenylalkylamine and indolealkylamine hallucinogens, as well as structurally similar nonhallucinogens, for their effect on human…”
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5HT2 receptor changes in rat cortex and platelets following chronic ritanserin and clorgyline administration by Twist, E C, Mitchell, S, Brazell, C, Stahl, S M, Campbell, I C

“…Chronic administration of clorgyline or ritanserin to adult rats for 28 days followed by a 3 day drug-free period results in a significant decrease in 5HT2…”
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