Search Results - "Braz, Joao"

Dorsal root ganglion macrophages contribute to both the initiation and persistence of neuropathic pain by Yu, Xiaobing, Liu, Hongju, Hamel, Katherine A., Morvan, Maelig G., Yu, Stephen, Leff, Jacqueline, Guan, Zhonghui, Braz, Joao M., Basbaum, Allan I.

“…Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant expansion and proliferation of macrophages around injured…”
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Low-Complexity Sphere Decoding Detector for Generalized Spatial Modulation Systems by Cal-Braz, Joao A., Sampaio-Neto, Raimundo

“…This letter presents a sphere decoding strategy for generalized spatial modulation (GSM) systems. The proposed modifications reduce the exhaustive tree search…”
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Microcircuit Mechanisms through which Mediodorsal Thalamic Input to Anterior Cingulate Cortex Exacerbates Pain-Related Aversion by Meda, Karuna S., Patel, Tosha, Braz, Joao M., Malik, Ruchi, Turner, Marc L., Seifikar, Helia, Basbaum, Allan I., Sohal, Vikaas S.

“…Hyperexcitability of the anterior cingulate cortex (ACC) is thought to drive aversion associated with chronic neuropathic pain. Here, we studied the…”
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Dorsal Horn Parvalbumin Neurons Are Gate-Keepers of Touch-Evoked Pain after Nerve Injury by Petitjean, Hugues, Pawlowski, Sophie Anne, Fraine, Steven Li, Sharif, Behrang, Hamad, Doulia, Fatima, Tarheen, Berg, Jim, Brown, Claire M., Jan, Lily-Yeh, Ribeiro-da-Silva, Alfredo, Braz, Joao M., Basbaum, Allan I., Sharif-Naeini, Reza

“…Neuropathic pain is a chronic debilitating disease that results from nerve damage, persists long after the injury has subsided, and is characterized by…”
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Structures of the σ2 receptor enable docking for bioactive ligand discovery by Alon, Assaf, Lyu, Jiankun, Braz, Joao M., Tummino, Tia A., Craik, Veronica, O’Meara, Matthew J., Webb, Chase M., Radchenko, Dmytro S., Moroz, Yurii S., Huang, Xi-Ping, Liu, Yongfeng, Roth, Bryan L., Irwin, John J., Basbaum, Allan I., Shoichet, Brian K., Kruse, Andrew C.

“…The σ 2 receptor has attracted intense interest in cancer imaging 1 , psychiatric disease 2 , neuropathic pain 3 – 5 and other areas of biology 6 , 7 . Here we…”
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Cell transplants to treat the “disease” of neuropathic pain and itch by Basbaum, Allan I., Bráz, João M.

“…Among many mechanisms implicated in the development of neuropathic pain after nerve damage is a profound dysfunction of GABAergic inhibitory controls,…”
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Pain and itch processing by subpopulations of molecularly diverse spinal and trigeminal projection neurons by Wercberger, Racheli, Braz, Joao M., Weinrich, Jarret A., Basbaum, Allan I.

“…A remarkable molecular and functional heterogeneity of the primary sensory neurons and dorsal horn interneurons transmits pain- and or itch-relevant…”
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GABAergic cell transplants in the anterior cingulate cortex reduce neuropathic pain aversiveness by Juarez-Salinas, Dina L, Braz, Joao M, Etlin, Alexander, Gee, Steven, Sohal, Vikaas, Basbaum, Allan I

“…Dysfunction of inhibitory circuits in the rostral anterior cingulate cortex underlies the affective (aversive), but not the sensory-discriminative features…”
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TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons by Yue, Wendy Wing Sze, Yuan, Lin, Braz, Joao M, Basbaum, Allan I, Julius, David

“…TRPV1, a capsaicin- and heat-activated ion channel, is expressed by peripheral nociceptors and has been implicated in various inflammatory and neuropathic pain…”
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Regulatory T-cells inhibit microglia-induced pain hypersensitivity in female mice by Kuhn, Julia A, Vainchtein, Ilia D, Braz, Joao, Hamel, Katherine, Bernstein, Mollie, Craik, Veronica, Dahlgren, Madelene W, Ortiz-Carpena, Jorge, Molofsky, Ari B, Molofsky, Anna V, Basbaum, Allan I

“…Peripheral nerve injury-induced neuropathic pain is a chronic and debilitating condition characterized by mechanical hypersensitivity. We previously identified…”
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Structure-based discovery of nonopioid analgesics acting through the α2A-adrenergic receptor by Fink, Elissa A, Xu, Jun, Hübner, Harald, Braz, Joao M, Seemann, Philipp, Avet, Charlotte, Craik, Veronica, Weikert, Dorothee, Schmidt, Maximilian F, Webb, Chase M, Tolmachova, Nataliya A, Moroz, Yurii S, Xi-Ping Huang, Kalyanaraman, Chakrapani, Gahbauer, Stefan, Chen, Geng, Liu, Zheng, Jacobson, Matthew P, Irwin, John J, Bouvier, Michel, Du, Yang, Shoichet, Brian K, Basbaum, Allan I, Gmeiner, Peter

“…A path to pain reliefThe serious problems associated with opioid addiction have motivated the search for non-opioid pain-relief drugs. The α2A-adrenergic…”
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Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness by Braz, Joao M., Dembo, Todd, Charruyer, Alexandra, Ghadially, Ruby, Fassett, Marlys S., Basbaum, Allan I.

“…Pruritus is a common symptom of inflammatory skin conditions, including atopic dermatitis (AD). Although primary sensory neurons that transmit pruritic signals…”
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Structure-Based Design of a Chemical Probe Set for the 5-HT5A Serotonin Receptor by Levit Kaplan, Anat, Strachan, Ryan T, Braz, Joao M, Craik, Veronica, Slocum, Samuel, Mangano, Thomas, Amabo, Vanessa, O'Donnell, Henry, Lak, Parnian, Basbaum, Allan I, Roth, Bryan L, Shoichet, Brian K

“…The 5-HT 5A receptor (5-HT 5A R), for which no selective agonists and a few antagonists exist, remains the least understood serotonin receptor. A single…”
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Presynaptic Inputs to Any CNS Projection Neuron Identified by Dual Recombinant Virus Infection by Bráz, João M, Wang, Fan, Basbaum, Allan I

“…Although neuroanatomical tracing studies have defined the origin and targets of major projection neurons (PN) of the central nervous system (CNS), there is…”
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Docking for EP4R antagonists active against inflammatory pain by Gahbauer, Stefan, DeLeon, Chelsea, Braz, Joao M., Craik, Veronica, Kang, Hye Jin, Wan, Xiaobo, Huang, Xi-Ping, Billesbølle, Christian B., Liu, Yongfeng, Che, Tao, Deshpande, Ishan, Jewell, Madison, Fink, Elissa A., Kondratov, Ivan S., Moroz, Yurii S., Irwin, John J., Basbaum, Allan I., Roth, Bryan L., Shoichet, Brian K.

“…The lipid prostaglandin E 2 (PGE 2 ) mediates inflammatory pain by activating G protein-coupled receptors, including the prostaglandin E2 receptor 4 (EP4R)…”
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Synergistic antipruritic effects of gamma aminobutyric acid A and B agonists in a mouse model of atopic dermatitis by Cevikbas, Ferda, Braz, Joao M., Wang, Xidao, Solorzano, Carlos, Sulk, Mathias, Buhl, Timo, Steinhoff, Martin, Basbaum, Allan I.

“…Despite recent insights into the pathophysiology of acute and chronic itch, chronic itch remains an often intractable condition. Among major contributors to…”
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Transplant restoration of spinal cord inhibitory controls ameliorates neuropathic itch by Braz, Joao M, Juarez-Salinas, Dina, Ross, Sarah E, Basbaum, Allan I

“…The transmission of pruritoceptive (itch) messages involves specific neural circuits within the spinal cord that are distinct from those that transmit pain…”
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Parallel “Pain” Pathways Arise from Subpopulations of Primary Afferent Nociceptor by Braz, Joao M., Nassar, Mohammed A., Wood, John N., Basbaum, Allan I.

“…A major unanswered question concerning “pain” circuitry is the extent to which different populations of primary afferent nociceptor engage the same or…”
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Peripheral and central neuronal ATF3 precedes CD4+ T-cell infiltration in EAE by Frezel, Noémie, Sohet, Fabien, Daneman, Richard, Basbaum, Allan I., Braz, Joao M.

“…Experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis produced by immunization with myelin oligodendrocyte glycoprotein (MOG)…”
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Contribution of dorsal horn CGRP-expressing interneurons to mechanical sensitivity by Löken, Line S, Braz, Joao M, Etlin, Alexander, Sadeghi, Mahsa, Bernstein, Mollie, Jewell, Madison, Steyert, Marilyn, Kuhn, Julia, Hamel, Katherine, Llewellyn-Smith, Ida J, Basbaum, Allan

“…Primary sensory neurons are generally considered the only source of dorsal horn calcitonin gene-related peptide (CGRP), a neuropeptide critical to the…”
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