Protective effects of estrogen against cardiovascular disease mediated via oxidative stress in the brain

Protective effects of estrogen against cardiovascular disease mediated via oxidative stress in the brain

During their reproductive years women produce significant levels of estrogens, predominantly in the form of estradiol, that are thought to play an important role in cardioprotection. Mechanisms underlying this action include both estrogen-mediated changes in gene expression, and post-transcriptional...

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Bibliographic Details
Published in:Life sciences (1973) Vol. 192; pp. 190 - 198
Main Authors: Lagranha, Claudia J., Silva, Tercya Lucidi Araujo, Silva, Severina Cassia A., Braz, Glaber Ruda F., da Silva, Aline Isabel, Fernandes, Mariana Pinheiro, Sellitti, Donald F.
Format: Journal Article
Language:English
Published: Netherlands Elsevier Inc 01-01-2018
Elsevier BV
Subjects:
17β-Estradiol
Brain
Brain damage
Brain injury
Brain stem
Brainstem
Cardiovascular disease
Cardiovascular diseases
Cardiovascular system
Disease control
Estradiol
Estrogens
Gene expression
Heart
Mechanical stimuli
Neurons
Neuroprotection
Outflow
Oxidation
Oxidative stress
Parasympathetic nervous system
Post-transcription
Reactive oxygen species
Sex hormones
Signaling
Transcription activation
Oxidative stress
Neuroprotection
Estradiol
Brainstem
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Summary:During their reproductive years women produce significant levels of estrogens, predominantly in the form of estradiol, that are thought to play an important role in cardioprotection. Mechanisms underlying this action include both estrogen-mediated changes in gene expression, and post-transcriptional activation of protein signaling cascades in the heart and in neural centers controlling cardiovascular function, in particular, in the brainstem. There, specific neurons, especially those of the bulbar region play an important role in the neuronal control of the cardiovascular system because they control the outflow of sympathetic activity and parasympathetic activity as well as the reception of chemical and mechanical signals. In the present review, we discuss how estrogens exert their cardioprotective effect in part by modulating the actions of internally generated products of cellular oxidation such as reactive oxygen species (ROS) in brain stem neurons. The significance of this review is in integrating the literature of oxidative damage in the brain with the literature of neuroprotection by estrogen in order to better understand both the benefits and limitations of using this hormone to prevent cardiovascular disease. [Display omitted]
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ISSN:0024-3205
1879-0631
DOI:10.1016/j.lfs.2017.11.043