Search Results - "Bray, Susan E."

ABCB1 (MDR1) induction defines a common resistance mechanism in paclitaxel- and olaparib-resistant ovarian cancer cells by Vaidyanathan, Aparajitha, Sawers, Lynne, Gannon, Anne-Louise, Chakravarty, Probir, Scott, Alison L, Bray, Susan E, Ferguson, Michelle J, Smith, Gillian

“…Background: Clinical response to chemotherapy for ovarian cancer is frequently compromised by the development of drug-resistant disease. The underlying…”
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IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes by James, Olivia J., Vandereyken, Maud, Marchingo, Julia M., Singh, Francois, Bray, Susan E., Wilson, Jamie, Love, Andrew G., Swamy, Mahima

“…Intestinal intraepithelial lymphocytes (IEL) are an abundant population of tissue-resident T cells that protect and maintain the intestinal barrier. IEL…”
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MAGE-A Cancer/Testis Antigens Inhibit MDM2 Ubiquitylation Function and Promote Increased Levels of MDM4 by Marcar, Lynnette, Ihrig, Bianca, Hourihan, John, Bray, Susan E, Quinlan, Philip R, Jordan, Lee B, Thompson, Alastair M, Hupp, Ted R, Meek, David W

“…Melanoma antigen A (MAGE-A) proteins comprise a structurally and biochemically similar sub-family of Cancer/Testis antigens that are expressed in many cancer…”
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The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection by Chen, Changwei, Gallagher, Jennifer R, Tarlton, Jamie, van Aalten, Lidy, Bray, Susan E, Ashford, Michael L J, McCrimmon, Rory J, Pearson, Ewan R, McNeilly, Alison D, Sutherland, Calum

“…The biguanide, metformin, is the first-choice therapeutic agent for type-2 diabetes, although the mechanisms that underpin metformin clinical efficacy remain…”
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Multimodality Characterization of Cancer-Associated Fibroblasts in Tumor Microenvironment and Its Correlation With Ultrasound Shear Wave-Measured Tissue Stiffness in Localized Prostate Cancer by Ageeli, Wael, Zhang, Xinyu, Ogbonnaya, Chidozie N, Bray, Susan E, Kernohan, Neil M, Wilson, Jennifer, Li, Chunhui, Nabi, Ghulam

“…Growing evidence suggests that the tumor microenvironment (TME) represented by cellular and acellular components plays a key role in the multistep process of…”
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Histological evaluation of AMPK signalling in primary breast cancer by Hadad, Sirwan M, Baker, Lee, Quinlan, Philip R, Robertson, Katherine E, Bray, Susan E, Thomson, George, Kellock, David, Jordan, Lee B, Purdie, Colin A, Hardie, David G, Fleming, Stewart, Thompson, Alastair M

“…AMP-activated protein kinase (AMPK) acts as a cellular fuel gauge that responds to energy stress by suppressing cell growth and biosynthetic processes, thus…”
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Wnt5a exhibits layer-specific expression in adult skin, is upregulated in psoriasis, and synergizes with type 1 interferon by Romanowska, Malgorzata, Evans, Alan, Kellock, David, Bray, Susan E, McLean, Kathleen, Donandt, Susanne, Foerster, John

“…Wnt5a is a member of the wingless-type patterning regulators important in pre-natal development. The expression and distribution of Wnt5a and its receptors…”
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EMSY expression affects multiple components of the skin barrier with relevance to atopic dermatitis by Elias, Martina S., Wright, Sheila C., Remenyi, Judit, Abbott, James C., Bray, Susan E., Cole, Christian, Edwards, Sharon, Gierlinski, Marek, Glok, Mateusz, McGrath, John A., Nicholson, William V., Paternoster, Lavinia, Prescott, Alan R., Have, Sara Ten, Whitfield, Phillip D., Lamond, Angus I., Brown, Sara J.

“…Atopic dermatitis (AD) is a common, complex, and highly heritable inflammatory skin disease. Genome-wide association studies offer opportunities to identify…”
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Immunohistochemical detection of Polo-like kinase-1 (PLK1) in primary breast cancer is associated with TP53 mutation and poor clinical outcom by King, Sharon I, Purdie, Colin A, Bray, Susan E, Quinlan, Philip R, Jordan, Lee B, Thompson, Alastair M, Meek, David W

“…Polo-like kinase-1 (PLK1) is a crucial driver of cell cycle progression and its down-regulation plays an important checkpoint role in response to DNA damage…”
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Cluster analyses of the TCGA and a TMA dataset using the coexpression of HSP27 and CRYAB improves alignment with clinical-pathological parameters of breast cancer and suggests different epichaperome influences for each sHSP by Quinlan, Philip R., Figeuredo, Grazziela, Mongan, Nigel, Jordan, Lee B., Bray, Susan E., Sreseli, Roman, Ashfield, Alison, Mitsch, Jurgen, van den Ijssel, Paul, Thompson, Alastair M., Quinlan, Roy A.

“…Our cluster analysis of the Cancer Genome Atlas for co-expression of HSP27 and CRYAB in breast cancer patients identified three patient groups based on their…”
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Immunohistochemical detection of Polo-like kinase-1 (PLK1) in primary breast cancer is associated with TP53 mutation and poor clinical outcome by King, Sharon I, Purdie, Colin A, Bray, Susan E, Quinlan, Philip R, Jordan, Lee B, Thompson, Alastair M, Meek, David W

“…Polo-like kinase-1 (PLK1) is a crucial driver of cell cycle progression and its down-regulation plays an important checkpoint role in response to DNA damage…”
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Ribosomal RNA 2'O-methylation as a novel layer of inter-tumour heterogeneity in breast cancer by Marcel, Virginie, Kielbassa, Janice, Marchand, Virginie, Natchiar, Kundhavai S, Paraqindes, Hermes, Nguyen Van Long, Flora, Ayadi, Lilia, Bourguignon-Igel, Valérie, Lo Monaco, Piero, Monchiet, Déborah, Scott, Véronique, Tonon, Laurie, Bray, Susan E, Diot, Alexandra, Jordan, Lee B, Thompson, Alastair M, Bourdon, Jean-Christophe, Dubois, Thierry, André, Fabrice, Catez, Frédéric, Puisieux, Alain, Motorin, Yuri, Klaholz, Bruno P, Viari, Alain, Diaz, Jean-Jacques

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The amino-acid stress sensing eIF2α kinase GCN2 is a survival biomarker for malignant mesothelioma by Gold, Lyssa T, Bray, Susan E, Kernohan, Neil M, Henderson, Nina, Nowicki, Maisie, Masson, Glenn R

“…Malignant mesothelioma is a tumour that is strongly associated with a history of asbestos exposure, and which derives from mesothelial cells that line the…”
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Ribosomal RNA 2′O-methylation as a novel layer of inter-tumour heterogeneity in breast cancer by Marcel, Virginie, Kielbassa, Janice, Marchand, Virginie, Natchiar, Kundhavai S, Paraqindes, Hermes, Nguyen Van Long, Flora, Ayadi, Lilia, Bourguignon-Igel, Valérie, Lo Monaco, Piero, Monchiet, Déborah, Scott, Véronique, Tonon, Laurie, Bray, Susan E, Diot, Alexandra, Jordan, Lee B, Thompson, Alastair M, Bourdon, Jean-Christophe, Dubois, Thierry, André, Fabrice, Catez, Frédéric, Puisieux, Alain, Motorin, Yuri, Klaholz, Bruno P, Viari, Alain, Diaz, Jean-Jacques

“…Abstract Recent epitranscriptomics studies unravelled that ribosomal RNA (rRNA) 2′O-methylation is an additional layer of gene expression regulation…”
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Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy by Thompson, Alastair M, Johnson, Andrea, Quinlan, Philip, Hillman, Grantland, Fontecha, Marcel, Bray, Susan E, Purdie, Colin A, Jordan, Lee B, Ferraldeschi, Roberta, Latif, Ayshe, Hadfield, Kirsten D, Clarke, Robert B, Ashcroft, Linda, Evans, D. Gareth, Howell, Anthony, Nikoloff, Michele, Lawrence, Jeffrey, Newman, William G

“…The association between CYP2D6 genotype and outcome in breast cancer patients treated with adjuvant tamoxifen remains controversial. We assessed the influence…”
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Phosphorylation of a splice variant of collapsin response mediator protein 2 in the nucleus of tumour cells links cyclin dependent kinase-5 to oncogenesis by Grant, Nicola J, Coates, Philip J, Woods, Yvonne L, Bray, Susan E, Morrice, Nicholas A, Hastie, C James, Lamont, Douglas J, Carey, Francis A, Sutherland, Calum

“…Cyclin-dependent protein kinase-5 (CDK5) is an unusual member of the CDK family as it is not cell cycle regulated. However many of its substrates have roles in…”
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Differences in the frequency of macrophage and T cell markers between focal and crescentic classes of anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis by Kidder, Dana, Bray, Susan E, Fleming, Stewart

“…Background: Anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis (AAGN) can be classified into; focal, crescentic, mixed and sclerotic…”
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Gene expression in colorectal neoplasia: modifications induced by tissue ischaemic time and tissue handling protocol by Bray, Susan E, Paulin, Fiona E M, Fong, Siew Chinn, Baker, Lee, Carey, Frank A, Levison, David A, Steele, Robert J C, Kernohan, Neil M

“…Bray S E, Paulin F E M, Fong S C, Baker L, Carey F A, Levison D A, Steele R J C & Kernohan N M
(2010) Histopathology56, 240–250 Gene expression in colorectal…”
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Seliciclib (CYC202, R‐roscovitine) enhances the antitumor effect of doxorubicin in vivo in a breast cancer xenograft model by Appleyard, Maria Virginia C.L., O'Neill, Mary A., Murray, Karen E., Paulin, Fiona E.M., Bray, Susan E., Kernohan, Neil M., Levison, David A., Lane, David P., Thompson, Alastair M.

“…We sought to determine whether seliciclib (CYC202, R‐roscovitine) could increase the antitumor effects of doxorubicin, with no increase in toxicity, in an MCF7…”
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Ribosomal RNA 2′ O-methylation as a novel layer of inter-tumour heterogeneity in breast cancer by Marcel, Virginie, Kielbassa, Janice, Marchand, Virginie, Natchiar, Kundhavai S, Paraqindes, Hermes, Van Long, Flora Nguyen, Ayadi, Lilia, Bourguignon-Igel, Valérie, Monaco, Piero Lo, Monchiet, Déborah, Scott, Véronique, Tonon, Laurie, Bray, Susan E, Diot, Alexandra, Jordan, Lee B, Thompson, Alastair M, Bourdon, Jean-Christophe, Dubois, Thierry, André, Fabrice, Catez, Frédéric, Puisieux, Alain, Motorin, Yuri, Klaholz, Bruno P, Viari, Alain, Diaz, Jean-Jacques

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