Search Results - "Bray, Cara"

Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2 by Bray, Cara, Wright, David, Haupt, Sonja, Thomas, Sharyn, Stauss, Hans, Zamoyska, Rose

“…A single nucleotide polymorphism, C1858T, in the gene encoding the protein tyrosine phosphatase nonreceptor type 22 ( ) results in one of the strongest genetic…”
Get full text

Assessing the total effect of time-varying predictors in prevention research by Bray, Bethany Cara, Almirall, Daniel, Zimmerman, Rick S, Lynam, Donald, Murphy, Susan A

“…Observational data are often used to address prevention questions such as, "If alcohol initiation could be delayed, would that in turn cause a delay in…”
Get full text

Multi-color Molecular Visualization of Signaling Proteins Reveals How C-Terminal Src Kinase Nanoclusters Regulate T Cell Receptor Activation by Simoncelli, Sabrina, Griffié, Juliette, Williamson, David J., Bibby, Jack, Bray, Cara, Zamoyska, Rose, Cope, Andrew P., Owen, Dylan M.

“…Elucidating the mechanisms that controlled T cell activation requires visualization of the spatial organization of multiple proteins on the submicron scale…”
Get full text

Using crispr to determine the effects of mutations of ptpn22 in human t cells by Bray, Cara

“…The haematopoietic phosphatase PTPN22 is a key regulator in balancing immune responses between self-reactivity and tolerance. PTPN22 downregulates T cell…”
Get full text

Abstract 5301: Tumor-targeted activation of CD137 using Bicycles : New insights into mechanism of action and discovery of BT7455, a clinical candidate for the treatment of EphA2-expressing cancers by Lahdenranta, Johanna, Hurov, Kristen, Cohen, Heather, Luus, Lia, Bray, Cara, Brown, Peter, Devlen, Anna, Campbell, Carly, Gray, Matthew, Kelly, Mike, Mudd, Gemma, Upadhyaya, Punit, Battula, Sailaja, Zhang, Kelvin, Dugast, Anne-Sophie, McDonnell, Kevin, Brandish, Phil, Keen, Nicholas

“…Introduction: Clinical studies in cancer patients have validated CD137 agonism as an activator of the immune system to enable tumor rejection. We have…”
Get full text

Abstract 1832: EphA2-dependent CD137 agonism and anti-tumor efficacy by BT7455, a Bicycle tumor-targeted immune cell agonist by Luus, Lia, Hurov, Kristen, Lahdenranta, Johanna, Shah, Chinmayee, Devlen, Anna, Kristensson, Julia, Brown, Peter, Bray, Cara, Cohen, Heather, Campbell, Carly, Mudd, Gemma, Upadhyaya, Punit, McDonnell, Kevin, Xu, Hongmei, Jeffrey, Phil, Brandish, Philip E., Keen, Nicholas

“…We have developed a new class of modular synthetic drugs, termed Bicycle® tumor-targeted immune cell agonists (Bicycle® TICAs), which are multi-specific…”
Get full text

Long-Term Prevalence and Demographic Trends in U.S. Adolescent Inhalant Use: Implications for Clinicians and Prevention Scientists by Halliburton, Amanda Elizabeth, Bray, Bethany Cara

“…Background: Inhalant use by adolescents is cause for concern due to the early age of inhalant use initiation and the many short- and long-term health…”
Get full text

Examining gambling and substance use: Applications of advanced latent class modeling techniques for cross-sectional and longitudinal data by Bray, Bethany Cara

“…The purpose of the current project is to present three empirical studies that illustrate the application of advanced latent class modeling techniques for…”
Get full text