Molecular Genetic Markers of Neuroglia in Traumatic Brain Injury and Their Use for the Functional Assessment of Sportsmen

Molecular Genetic Markers of Neuroglia in Traumatic Brain Injury and Their Use for the Functional Assessment of Sportsmen

Neuroglia performs multiple important physiological functions, including maintenance of brain homeostasis and metabolism, neuroprotection and modulation of neurotransmission. Studying the role of neuroglia is essential for understanding the pathogenesis of neurodegenerative diseases, as well as nerv...

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Bibliographic Details
Published in:Journal of evolutionary biochemistry and physiology Vol. 60; no. 4; pp. 1490 - 1503
Main Authors: Cherepanova, A. V., Bravy, Yu. R., Karabelsky, A. V., Kotova, M. M., Shcherbakova, A. S., Apukhtin, K. V., Nikitin, V. S., Bobrov, M. Yu, Kalueff, A. V.
Format: Journal Article
Language:English
Published: Moscow Pleiades Publishing 01-07-2024
Springer Nature B.V
Subjects:
Animal Physiology
Biochemistry
Biomedical and Life Sciences
Evolutionary Biology
Genetic markers
Glia
Glial cells
Homeostasis
Life Sciences
Nervous system
Neurodegenerative diseases
Neuromodulation
Neuroprotection
Neurotransmission
Reviews
Traumatic brain injury
sports physiology
astroglia
biomarkers of neuroglia
microglia
oligodendroglia
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Summary:Neuroglia performs multiple important physiological functions, including maintenance of brain homeostasis and metabolism, neuroprotection and modulation of neurotransmission. Studying the role of neuroglia is essential for understanding the pathogenesis of neurodegenerative diseases, as well as nervous tissue repair in inflammation or traumatic brain injuries, not infrequent in sports. However, it is difficult to analyze the processes occurring in neuroglial cells because of their high heterogeneity and no system of biomarkers allowing unambiguous assessment of the nervous system’s functional state as a whole. Here we analyze the data on clinically and biologically significant molecular genetic markers of different types of neuroglia and discuss the prospects for their use in sports physiology, including the functional assessment of athletes with TBI of varying severity and other types of sports-related traumas.
ISSN:0022-0930
1608-3202
DOI:10.1134/S0022093024040185