Search Results - "Braunstein, Miriam"

The SecA2 pathway of Mycobacterium tuberculosis exports effectors that work in concert to arrest phagosome and autophagosome maturation by Zulauf, Katelyn E, Sullivan, Jonathan Tabb, Braunstein, Miriam

“…To subvert host defenses, Mycobacterium tuberculosis (Mtb) avoids being delivered to degradative phagolysosomes in macrophages by arresting the normal host…”
Get full text

Development and Characterization of a Dry Powder Formulation for Anti-Tuberculosis Drug Spectinamide 1599 by Stewart, Ian E., Lukka, Pradeep B., Liu, Jiuyu, Meibohm, Bernd, Gonzalez-Juarrero, Mercedes, Braunstein, Miriam S., Lee, Richard E., Hickey, Anthony J.

“…Purpose Human tuberculosis (TB) is a global health problem that causes nearly 2 million deaths per year. Anti-TB therapy exists, but it needs to be…”
Get full text

Bacteriophage infection and killing of intracellular Mycobacterium abscessus by Schmalstig, Alan A, Wiggins, Andrew, Badillo, Debbie, Wetzel, Katherine S, Hatfull, Graham F, Braunstein, Miriam

“…As we rapidly approach a post-antibiotic era, bacteriophage (phage) therapy may offer a solution for treating drug-resistant bacteria. is an emerging,…”
Get full text

A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis by Kim, Manse, Johnson, Claire E., Schmalstig, Alan A., Annis, Ayano, Wessel, Sarah E., Van Horn, Brian, Schauer, Amanda, Exner, Agata A., Stout, Jason E., Wahl, Angela, Braunstein, Miriam, Victor Garcia, J., Kovarova, Martina

“…Tuberculosis (TB) is a communicable disease caused by Mycobacterium tuberculosis ( Mtb ) and is a major cause of morbidity and mortality. Successful treatment…”
Get full text

The Mycobacterium tuberculosis SecA2 System Subverts Phagosome Maturation To Promote Growth in Macrophages by TABB SULLIVAN, Jonathan, YOUNG, Ellen F, MCCANN, Jessica R, BRAUNSTEIN, Miriam

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
Get full text

Filtration improves the performance of a high-throughput screen for anti-mycobacterial compounds by Cheng, Nancy, Porter, Melissa A, Frick, Lloyd W, Nguyen, Yvonne, Hayden, Jennifer D, Young, Ellen F, Braunstein, Miriam S, Hull-Ryde, Emily A, Janzen, William P

“…The tendency for mycobacteria to aggregate poses a challenge for their use in microplate based assays. Good dispersions have been difficult to achieve in…”
Get full text

The ins and outs of Mycobacterium tuberculosis protein export by Ligon, Lauren S, Hayden, Jennifer D, Braunstein, Miriam

“…Summary Mycobacterium tuberculosis is an important pathogen that infects approximately one-third of the world’s population and kills almost two million people…”
Get full text

Thiopeptides Induce Proteasome-Independent Activation of Cellular Mitophagy by Bird, Kelly E, Xander, Christian, Murcia, Sebastian, Schmalstig, Alan A, Wang, Xianxi, Emanuele, Michael J, Braunstein, Miriam, Bowers, Albert A

“…Thiopeptide antibiotics are emerging clinical candidates that exhibit potent antibacterial activity against a variety of intracellular pathogens, including…”
Get full text

Granuloma formation and host defense in chronic Mycobacterium tuberculosis infection requires PYCARD/ASC but not NLRP3 or caspase-1 by McElvania Tekippe, Erin, Allen, Irving C, Hulseberg, Paul D, Sullivan, Jonathan T, McCann, Jessica R, Sandor, Matyas, Braunstein, Miriam, Ting, Jenny P-Y

“…The NLR gene family mediates host immunity to various acute pathogenic stimuli, but its role in chronic infection is not known. This paper addressed the role…”
Get full text

Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis by Hinchey, Joseph, Lee, Sunhee, Jeon, Bo Y, Basaraba, Randall J, Venkataswamy, Manjunatha M, Chen, Bing, Chan, John, Braunstein, Miriam, Orme, Ian M, Derrick, Steven C, Morris, Sheldon L, Jacobs, Jr, William R, Porcelli, Steven A

“…The inhibition of apoptosis of infected host cells is a well-known but poorly understood function of pathogenic mycobacteria. We show that inactivation of the…”
Get full text

Efficacy of pyrazinoic acid dry powder aerosols in resolving necrotic and non-necrotic granulomas in a guinea pig model of tuberculosis by Montgomery, Stephanie A, Young, Ellen F, Durham, Phillip G, Zulauf, Katelyn E, Rank, Laura, Miller, Brittany K, Hayden, Jennifer D, Lin, Feng-Chang, Welch, John T, Hickey, Anthony J, Braunstein, Miriam

“…New therapeutic strategies are needed to treat drug resistant tuberculosis (TB) and to improve treatment for drug sensitive TB. Pyrazinamide (PZA) is a…”
Get full text

Silencing Essential Protein Secretion in Mycobacterium smegmatis by Using Tetracycline Repressors by GUO, Xinzheng V, MONTELEONE, Mercedes, KLOTZSCHE, Marcus, KAMIONKA, Annette, HILLEN, Wolfgang, BRAUNSTEIN, Miriam, EHRT, Sabine, SCHNAPPINGER, Dirk

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

Characterization of NLRP12 during the in vivo host immune response to Klebsiella pneumoniae and Mycobacterium tuberculosis by Allen, Irving C, McElvania-TeKippe, Erin, Wilson, Justin E, Lich, John D, Arthur, Janelle C, Sullivan, Jonathan T, Braunstein, Miriam, Ting, Jenny P Y

“…The majority of nucleotide binding domain leucine rich repeats-containing (NLR) family members has yet to be functionally characterized. Of the described NLRs,…”
Get full text

Development of a Minimalistic Physiologically Based Pharmacokinetic (mPBPK) Model for the Preclinical Development of Spectinamide Antibiotics by Parmar, Keyur R, Lukka, Pradeep B, Wagh, Santosh, Temrikar, Zaid H, Liu, Jiuyu, Lee, Richard E, Braunstein, Miriam, Hickey, Anthony J, Robertson, Gregory T, Gonzalez-Juarrero, Mercedes, Edginton, Andrea, Meibohm, Bernd

“…Spectinamides 1599 and 1810 are lead spectinamide compounds currently under preclinical development to treat multidrug-resistant (MDR) and extensively…”
Get full text

Mycobacterium tuberculosis SatS is a chaperone for the SecA2 protein export pathway by Miller, Brittany K, Hughes, Ryan, Ligon, Lauren S, Rigel, Nathan W, Malik, Seidu, Anjuwon-Foster, Brandon R, Sacchettini, James C, Braunstein, Miriam

“…The SecA2 protein export system is critical for the virulence of . However, the mechanism of this export pathway remains unclear. Through a screen for…”
Get full text

Suppressor Analysis Reveals a Role for SecY in the SecA2-Dependent Protein Export Pathway of Mycobacteria by Ligon, Lauren S, Rigel, Nathan W, Romanchuk, Artur, Jones, Corbin D, Braunstein, Miriam

“…All bacteria use the conserved Sec pathway to transport proteins across the cytoplasmic membrane, with the SecA ATPase playing a central role in the process…”
Get full text

Protein Export by the Mycobacterial SecA2 System Is Determined by the Preprotein Mature Domain by Feltcher, Meghan E, Gibbons, Henry S, Ligon, Lauren S, Braunstein, Miriam

“…At the core of the bacterial general secretion (Sec) pathway is the SecA ATPase, which powers translocation of unfolded preproteins containing Sec signal…”
Get full text

Inhaled Pyrazinoic Acid Esters for the Treatment of Tuberculosis by Young, E. F., Perkowski, E., Malik, S., Hayden, J. D., Durham, P. G., Zhong, L., Welch, J. T., Braunstein, Miriam S., Hickey, Anthony J.

“…Purpose Analog development of existing drugs and direct drug delivery to the lungs by inhalation as treatments for multiple and extensively drug resistant (MDR…”
Get full text

Primary Lung Dendritic Cell Cultures to Assess Efficacy of Spectinamide-1599 Against Intracellular Mycobacterium tuberculosis by Santos, Karen, Lukka, Pradeep B, Grzegorzewicz, Anne, Jackson, Mary, Trivedi, Ashit, Pavan, Fernando, Chorilli, Marlus, Braunstein, Miriam, Hickey, Anthony, Meibohm, Bernd, Gonzalez-Juarrero, Mercedes

“…There is an urgent need to treat tuberculosis (TB) quickly, effectively and without side effects. (Mtb), the causative organism of TB, can survive for long…”
Get full text

Disposable Dosators for Pulmonary Insufflation of Therapeutic Agents to Small Animals by Durham, Phillip G, Hanif, Shumaila N, Contreras, Lucia Garcia, Young, Ellen F, Braunstein, Miriam S, Hickey, Anthony J

“…Development of new therapeutic products requires efficacy testing in an animal model. The pulmonary route of administration can be utilized to deliver drugs…”
Get full text