Search Results - "Braunstein, Jutta"

Complement deficiencies and dysregulation: Pathophysiological consequences, modern analysis, and clinical management by Schröder-Braunstein, Jutta, Kirschfink, Michael

“…•Complement deficiencies are increasingly recognized and present an unexpected wide spectrum of diseases.•Modern comprehensive complement analysis allows early…”
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Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen by Rollenske, Tim, Szijarto, Valeria, Lukasiewicz, Jolanta, Guachalla, Luis M., Stojkovic, Katarina, Hartl, Katharina, Stulik, Lukas, Kocher, Simone, Lasitschka, Felix, Al-Saeedi, Mohammed, Schröder-Braunstein, Jutta, von Frankenberg, Moritz, Gaebelein, Gereon, Hoffmann, Peter, Klein, Sabrina, Heeg, Klaus, Nagy, Eszter, Nagy, Gabor, Wardemann, Hedda

“…Humoral immune responses to microbial polysaccharide surface antigens can prevent bacterial infection but are typically strain specific and fail to mediate…”
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Keratinocytes costimulate naive human T cells via CD2: a potential target to prevent the development of proinflammatory Th1 cells in the skin by Orlik, Christian, Deibel, Daniel, Küblbeck, Johanna, Balta, Emre, Ganskih, Sabina, Habicht, Jüri, Niesler, Beate, Schröder-Braunstein, Jutta, Schäkel, Knut, Wabnitz, Guido, Samstag, Yvonne

“…The interplay between keratinocytes and immune cells, especially T cells, plays an important role in the pathogenesis of chronic inflammatory skin diseases…”
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Type I and Type III Interferons Display Different Dependency on Mitogen-Activated Protein Kinases to Mount an Antiviral State in the Human Gut by Pervolaraki, Kalliopi, Stanifer, Megan L, Münchau, Stephanie, Renn, Lynnsey A, Albrecht, Dorothee, Kurzhals, Stefan, Senís, Elena, Grimm, Dirk, Schröder-Braunstein, Jutta, Rabin, Ronald L, Boulant, Steeve

“…Intestinal epithelial cells (IECs) are constantly exposed to commensal flora and pathogen challenges. How IECs regulate their innate immune response to…”
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Inflammation induces pro-NETotic neutrophils via TNFR2 signaling by Neuenfeldt, Friederike, Schumacher, Jan Christoph, Grieshaber-Bouyer, Ricardo, Habicht, Jüri, Schröder-Braunstein, Jutta, Gauss, Annika, Merle, Uta, Niesler, Beate, Heineken, Niko, Dalpke, Alexander, Gaida, Matthias M., Giese, Thomas, Meuer, Stefan, Samstag, Yvonne, Wabnitz, Guido

“…Cytokines released during chronic inflammatory diseases induce pro-inflammatory properties in polymorphonuclear neutrophils (PMNs). Here, we describe the…”
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Postnatal human enteric neurospheres show a remarkable molecular complexity by Schmitteckert, Stefanie, Mederer, Tanja, Röth, Ralph, Günther, Patrick, Holland‐Cunz, Stefan, Metzger, Marco, Samstag, Yvonne, Schröder‐Braunstein, Jutta, Wabnitz, Guido, Kurzhals, Stefan, Scheuerer, Jutta, Beretta, Carlo A., Lasitschka, Felix, Rappold, Gudrun A., Romero, Philipp, Niesler, Beate

“…Background The enteric nervous system (ENS), a complex network of neurons and glial cells, coordinates major gastrointestinal functions. Impaired development…”
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Keratinocyte-induced costimulation of human T cells through CD6 - but not CD2 - activates mTOR and prevents oxidative stress by Orlik, Christian, Berschneider, Karina M., Jahraus, Beate, Niesler, Beate, Balta, Emre, Schäkel, Knut, Schröder-Braunstein, Jutta, Souto-Carneiro, Maria Margarida, Samstag, Yvonne

“…In psoriasis and other inflammatory skin diseases, keratinocytes (KCs) secrete chemokines that attract T cells, which, in turn, cause epidermal hyperplasia by…”
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Germline C1GALT1C1 mutation causes a multisystem chaperonopathy by Erger, Florian, Aryal, Rajindra P, Reusch, Björn, Matsumoto, Yasuyuki, Meyer, Robert, Zeng, Junwei, Knopp, Cordula, Noel, Maxence, Muerner, Lukas, Wenzel, Andrea, Kohl, Stefan, Tschernoster, Nikolai, Rappl, Gunter, Rouvet, Isabelle, Schröder-Braunstein, Jutta, Seibert, Felix S, Thiele, Holger, Häusler, Martin G, Weber, Lutz T, Büttner-Herold, Maike, Elbracht, Miriam, Cummings, Sandra F, Altmüller, Janine, Habbig, Sandra, Cummings, Richard D, Beck, Bodo B

“…Mutations in genes encoding molecular chaperones can lead to chaperonopathies, but none have so far been identified causing congenital disorders of…”
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STATs Dimerize in the Absence of Phosphorylation by Braunstein, Jutta, Brutsaert, Siska, Olson, Rich, Schindler, Christian

“…Upon activation by tyrosine kinases, members of the STAT family of transcription factors form stable dimers that are able to rapidly translocate to the nucleus…”
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Standardization of a human organ culture model of intestinal inflammation and its application for drug testing by Szikszai, Timea, Lasitschka, Felix, Giese, Thomas, Greulich, Matthias, Lee, Young-Seon, Ilse, Juliane, Schiessling, Serin, Leowardi, Christine, Al-Saeedi, Mohammed, Winter, Johannes, Meuer, Stefan, Schröder-Braunstein, Jutta

“…Targeting early molecular events in intestinal inflammation may represent a useful therapeutic strategy for maintaining remission in inflammatory bowel…”
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Human monocytes downregulate innate response receptors following exposure to the microbial metabolite n‐butyrate by Lasitschka, Felix, Giese, Thomas, Paparella, Marco, Kurzhals, Stefan R., Wabnitz, Guido, Jacob, Katrin, Gras, Judith, Bode, Konrad A., Heninger, Anne‐Kristin, Sziskzai, Timea, Samstag, Yvonne, Leszinski, Cornelia, Jocher, Bettina, Al‐Saeedi, Mohammed, Meuer, Stefan C., Schröder‐Braunstein, Jutta

“…Introduction Hyporesponsiveness of human lamina propria immune cells to microbial and nutritional antigens represents one important feature of intestinal…”
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Insights into the metastatic bone marrow niche gained from fibronectin and β1 integrin transgenic mice by Wirth, Franziska, Zoeller, Caren, Lubosch, Alexander, Schroeder-Braunstein, Jutta, Wabnitz, Guido, Nakchbandi, Inaam A.

“…•Changes in stromal cells mostly, but not always, impact both the pre-metastatic niche for breast cancer and the hematopoietic stem cell niche•Fibronectin…”
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Initiation of an inflammatory response in resident intestinal lamina propria cells -use of a human organ culture model by Schröder-Braunstein, Jutta, Gras, Judith, Brors, Benedikt, Schwarz, Sonja, Szikszai, Timea, Lasitschka, Felix, Wabnitz, Guido, Heidtmann, Antje, Lee, Young-Seon, Schiessling, Serin, Leowardi, Christine, Al-Saeedi, Mohammed, Ulrich, Alexis, Engelke, Antonia, Winter, Johannes, Samstag, Yvonne, Giese, Thomas, Meuer, Stefan

“…Resident human lamina propria immune cells serve as powerful effectors in host defense. Molecular events associated with the initiation of an intestinal…”
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A Prominent Role for Mucosal Cystine/Cysteine Metabolism in Intestinal Immunoregulation by Sido, Bernd, Lasitschka, Felix, Giese, Thomas, Gassler, Nikolaus, Funke, Benjamin, Schröder–Braunstein, Jutta, Brunnemer, Ulf, Meuer, Stefan C, Autschbach, Frank

“…Background & Aims: T-cell receptor reactivity of intestinal lamina propria T cells (LP-T) critically depends on the capacity of local accessory cells to…”
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Immunomodulation of human intestinal T cells by the synthetic CD80 antagonist RhuDex by Heninger, Anne‐Kristin, Wentrup, Sabine, Al‐Saeedi, Mohammed, Schiessling, Serin, Giese, Thomas, Wartha, Florian, Meuer, Stefan, Schröder‐Braunstein, Jutta

“…Deregulated activation of mucosal lamina propria T cells plays a central role in the pathogenesis of intestinal inflammation. One of the means to attenuate T…”
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In Situ Expression of Interleukin-10 in Noninflamed Human Gut and in Inflammatory Bowel Disease by Autschbach, Frank, Braunstein, Jutta, Helmke, Burkhard, Zuna, Ivan, Schürmann, Guido, Niemir, Zofia I., Wallich, Reinhard, Otto, Herwart F., Meuer, Stefan C.

“…A dysregulated secretion of contra-inflammatory cytokines such as interleukin-10 (IL-10) could play a role in the pathogenesis of inflammatory bowel disease…”
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Differential Levels of Intercellular Glutathion (GSH) Dictate the Shift From Adaptive to Innate T Cell Function in the Human Intestinal Mucosa by Sido, Bernd, Senior Physician, Department of Surgery, Heidelberg, Germany, Autschbach, Frank, Senior Physician, Institute of Pathology, Heidelberg, Germany, Schroeder-Braunstein, Jutta, Scientist, Institute of Immunology, Heidelberg, Germany, Giese, Thomas, Group Leader, Institute of Immunology, Heidelberg, Germany, Lasitschka, Felix, Postdoctoral Fellow, Institute of Immunology, Heidelberg, Germany, Meuer, Stefan, Director, Institute of Immunology, Heidelberg, Germany

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Compartment-specific Expression of ALCAM (CD166) in Inflammatory Bowel Diseases by Lasitschka, Felix, Schroeder, Kristina, Giese, Thomas, Schwarz, Sonja, Schroeder-Braunstein, Jutta, Meuer, Stefan

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F.114. Mucosal Injury and Activation of NFkB in the Initiation of Intestinal Inflammation by Schwarz, Sonja, Giese, Thomas, Lasitschka, Felix, Wabnitz, Guido, Sido, Bernd, Autschbach, Frank, Lee, Young-Seon, Meuer, Stefan, Schröder-Braunstein, Jutta

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Thiol-mediated redox regulation of intestinal lamina propria T lymphocytes by Sido, B, Braunstein, J, Breitkreutz, R, Herfarth, C, Meuer, S C

“…Intestinal lamina propria T lymphocytes (LP-Ts) have a markedly low proliferative potential both in vivo and in vitro. Here, we have identified that the…”
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