Search Results - "Braunstein, Evan"

Direct activation of the alternative complement pathway by SARS-CoV-2 spike proteins is blocked by factor D inhibition by Yu, Jia, Yuan, Xuan, Chen, Hang, Chaturvedi, Shruti, Braunstein, Evan M., Brodsky, Robert A.

“…Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a highly contagious respiratory virus that can lead to venous/arterial thrombosis, stroke,…”
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Antiphospholipid syndrome: Complement activation, complement gene mutations, and therapeutic implications by Chaturvedi, Shruti, Braunstein, Evan M., Brodsky, Robert A.

“…Antiphospholipid syndrome (APS) is an acquired thromboinflammatory disorder characterized by the presence of antiphospholipid antibodies as well as an…”
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Complement activity and complement regulatory gene mutations are associated with thrombosis in APS and CAPS by Chaturvedi, Shruti, Braunstein, Evan M., Yuan, Xuan, Yu, Jia, Alexander, Alice, Chen, Hang, Gavriilaki, Eleni, Alluri, Ravi, Streiff, Michael B., Petri, Michelle, Crowther, Mark A., McCrae, Keith R., Brodsky, Robert A.

“…The antiphospholipid syndrome (APS) is characterized by thrombosis and/or pregnancy morbidity in the presence of antiphospholipid antibodies, including…”
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Aspirin in ET: will twice a day keep thrombosis away? by Braunstein, Evan M., Chaturvedi, Shruti

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Complement dysregulation is associated with severe COVID-19 illness by Yu, Jia, Gerber, Gloria F, Chen, Hang, Yuan, Xuan, Chaturvedi, Shruti, Braunstein, Evan M, Brodsky, Robert A

“…Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) may manifest as thrombosis, stroke, renal failure, myocardial infarction, and thrombocytopenia,…”
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Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia by Churpek, Jane E., Pyrtel, Khateriaa, Kanchi, Krishna-Latha, Shao, Jin, Koboldt, Daniel, Miller, Christopher A., Shen, Dong, Fulton, Robert, O’Laughlin, Michelle, Fronick, Catrina, Pusic, Iskra, Uy, Geoffrey L., Braunstein, Evan M., Levis, Mark, Ross, Julie, Elliott, Kevin, Heath, Sharon, Jiang, Allan, Westervelt, Peter, DiPersio, John F., Link, Daniel C., Walter, Matthew J., Welch, John, Wilson, Richard, Ley, Timothy J., Godley, Lucy A., Graubert, Timothy A.

“…Familial clustering of myelodysplastic syndromes (MDSs) and acute myeloid leukemia (AML) can be caused by inherited factors. We screened 59 individuals from 17…”
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COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria by Gerber, Gloria F., Yuan, Xuan, Yu, Jia, Cher, Benjamin A.Y., Braunstein, Evan M., Chaturvedi, Shruti, Brodsky, Robert A.

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Efficient and Allele-Specific Genome Editing of Disease Loci in Human iPSCs by Smith, Cory, Abalde-Atristain, Leire, He, Chaoxia, Brodsky, Brett R, Braunstein, Evan M, Chaudhari, Pooja, Jang, Yoon-Young, Cheng, Linzhao, Ye, Zhaohui

“…Efficient and precise genome editing is crucial for realizing the full research and therapeutic potential of human induced pluripotent stem cells (iPSCs)…”
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The roles of sex and genetics in the MPN by Moliterno, Alison R, Braunstein, Evan M

“…The Philadelphia chromosome negative myeloproliferative neoplasms(MPNs), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis…”
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SARS-CoV-2 vaccination and immune thrombotic thrombocytopenic purpura by Shah, Hridaya, Kim, Ann, Sukumar, Senthil, Mazepa, Marshall, Kohli, Ruhail, Braunstein, Evan M., Brodsky, Robert A., Cataland, Spero, Chaturvedi, Shruti

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Reduced ADAMTS13 activity during TTP remission is associated with stroke in TTP survivors by Upreti, Harshvardhan, Kasmani, Jamil, Dane, Kathryn, Braunstein, Evan M., Streiff, Michael B., Shanbhag, Satish, Moliterno, Alison R., Sperati, C. John, Gottesman, Rebecca F., Brodsky, Robert A., Kickler, Thomas S., Chaturvedi, Shruti

“…With timely and effective treatment, most patients with thrombotic thrombocytopenic purpura (TTP) survive the acute TTP episode. In addition to the risk of…”
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Recurrent germline variant in ATM associated with familial myeloproliferative neoplasms by Braunstein, Evan M., Imada, Eddie, Pasca, Sergiu, Wang, Shiyu, Chen, Hang, Alba, Camille, Hupalo, Dan N., Wilkerson, Matthew, Dalgard, Clifton L., Ghannam, Jack, Liu, Yujia, Marchionni, Luigi, Moliterno, Alison, Hourigan, Christopher S., Gondek, Lukasz P.

“…Genetic predisposition (familial risk) in the myeloproliferative neoplasms (MPNs) is more common than the risk observed in most other cancers, including…”
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Reduced sensitivity of PLASMIC and French scores for the diagnosis of thrombotic thrombocytopenic purpura in older individuals by Liu, Angela, Dhaliwal, Noor, Upreti, Harshvardhan, Kasmani, Jamil, Dane, Kathryn, Moliterno, Alison, Braunstein, Evan, Brodsky, Robert, Chaturvedi, Shruti

“…Background Thrombotic thrombocytopenic purpura (TTP) is a life‐threatening disorder characterized by thrombocytopenia, microangiopathic hemolysis, and ischemic…”
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Characterization of myeloproliferative neoplasms in the paediatric and young adult population by Harris, Zoey, Kaizer, Hannah, Wei, Aria, Karantanos, Theodoros, Williams, Donna M., Chaturvedi, Shruti, Jain, Tania, Resar, Linda, Moliterno, Alison R., Braunstein, Evan M.

“…Summary The aim of this study was to compare the genomic features and clinical outcomes between paediatric and young adult patients (PAYA, <40 years) and older…”
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Chronic myeloid leukemia (CML) evolves from Philadelphia chromosome-negative myeloproliferative neoplasms (MPNs) with unexpected frequency by Hochman, Michael J., Smith, B. Douglas, Karantanos, Theodoros, Braunstein, Evan M., Gojo, Ivana, Jain, Tania, Streiff, Michael B., Moliterno, Alison R., DeZern, Amy E.

“…Myeloproliferative neoplasms (MPN) are chronic clonal disorders characterized by overproduction of myeloid-lineage blood cells and potential risk of evolution…”
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A hypomorphic PIGA gene mutation causes severe defects in neuron development and susceptibility to complement-mediated toxicity in a human iPSC model by Yuan, Xuan, Li, Zhe, Baines, Andrea C, Gavriilaki, Eleni, Ye, Zhaohui, Wen, Zhexing, Braunstein, Evan M, Biesecker, Leslie G, Cheng, Linzhao, Dong, Xinzhong, Brodsky, Robert A

“…Mutations in genes involved in glycosylphosphatidylinositol (GPI) anchor biosynthesis underlie a group of congenital syndromes characterized by severe…”
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Two novel germline DDX41 mutations in a family with inherited myelodysplasia/acute myeloid leukemia by Li, Ruijuan, Sobreira, Nara, Witmer, P Dane, Pratz, Keith W, Braunstein, Evan M

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Silent cerebral infarction during immune TTP remission: prevalence, predictors, and impact on cognition by Chaturvedi, Shruti, Yu, Jia, Brown, Jenna, Wei, Aria, Selvakumar, Sruthi, Gerber, Gloria F., Moliterno, Alison R., Streiff, Michael B., Kraus, Peggy, Logue, Claire M., Yui, Jennifer C., Naik, Rakhi P., Latif, Hira, Lanzkron, Sophie M., Braunstein, Evan M., Brodsky, Robert A., Gottesman, Rebecca F., Lin, Doris D.

“…•SCI is common in iTTP in clinical remission.•SCI is associated with mild and major cognitive impairment independent of stroke history and depression. [Display…”
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Anti-PF4 antibodies associated with disease severity in COVID-19 by Liu, Qingbo, Miao, Huiyi, Li, Shuai, Zhang, Peng, Gerber, Gloria F., Follmann, Dean, Ji, Hongkai, Zeger, Scott L., Chertow, Daniel S., Quinn, Thomas C., Robinson, Matthew L., Kickler, Thomas S., Rothman, Richard E., Fenstermacher, Katherine Z. J., Braunstein, Evan M., Cox, Andrea L., Farci, Patrizia, Fauci, Anthony S., Lusso, Paolo

“…Severe COVID-19 is characterized by a prothrombotic state associated with thrombocytopenia, with microvascular thrombosis being almost invariably present in…”
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A prospective quality improvement initiative in adult hemophagocytic lymphohistiocytosis to improve testing and a framework to facilitate trigger identification and mitigate hemorrhage from retrospective analysis by Merrill, Samuel A., Naik, Rakhi, Streiff, Michael B., Shanbhag, Satish, Lanzkron, Sophie, Braunstein, Evan M., Moliterno, Alison M., Brodsky, Robert A.

“…Hemophagocytic lymphohistiocytosis (HLH) is a highly fatal, hyperinflammatory syndrome in adults triggered by an underlying illness in most cases. As such,…”
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