Search Results - "Braunreiter, Kara M."
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Inhibition of Bromodomain and Extra Terminal (BET) Domain Activity Modulates the IL-23R/IL-17 Axis and Suppresses Acute Graft- Versus -Host Disease
Published in Frontiers in oncology (15-10-2021)“…Acute graft- -host disease (GVHD) is the leading cause of non-relapse mortality following allogeneic hematopoietic cell transplantation. The majority of…”
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A tale of two clocks: phosphorylation of NICD by CDKs links cell cycle and segmentation clock
Published in EMBO reports (01-07-2019)“…The Notch signaling pathway is tightly controlled via post‐transcriptional regulatory mechanisms that promote or terminate pathway activity. In this issue,…”
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3
A tale of two clocks: phosphorylation of NICD by CDKs links cell cycle and segmentation clock
Published in EMBO reports (01-07-2019)“…The Notch signaling pathway is tightly controlled via post-transcriptional regulatory mechanisms that promote or terminate pathway activity. In this issue,…”
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4
GREB1 isoforms regulate proliferation independent of ERα co-regulator activities in breast cancer
Published in Endocrine-related cancer (01-07-2018)“…Activation of the transcription factor estrogen receptor α (ERα) and the subsequent regulation of estrogen-responsive genes play a crucial role in the…”
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Disruption of somitogenesis by a novel dominant allele of Lfng suggests important roles for protein processing and secretion
Published in Development (Cambridge) (01-03-2016)“…Vertebrate somitogenesis is regulated by a segmentation clock. Clock-linked genes exhibit cyclic expression, with a periodicity matching the rate of somite…”
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A novel targeted Lunatic fringe allele predicted to reduce protein secretion is dominant and disrupts somitogenesis
Published in Development (Cambridge) (01-01-2016)“…Vertebrate somitogenesis is regulated by a segmentation clock. Clock-linked genes exhibit cyclic expression, with a periodicity matching the rate of somite…”
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CRISPR/Cas9 deletion of MIR155HG in human T cells reduces incidence and severity of acute GVHD in a xenogeneic model
Published in Blood advances (27-02-2024)“…•MIR155HGΔexon3 T cells provide protection against lethal acute GVHD in a xenogeneic mouse model of disease.•MIR155HGΔexon3 T cells maintain beneficial…”
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Spectral and copper binding properties of methanobactin from the facultative methanotroph Methylocystis strain SB2
Published in Journal of inorganic biochemistry (01-05-2012)“…Methanobactin (mb) is the first characterized example of a chalkophore, a class of copper-binding chromopeptides similar to iron-binding siderophores…”
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A tale of two clocks: phosphorylation of NICD by CDK s links cell cycle and segmentation clock
Published in EMBO reports (01-07-2019)Get full text
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10
CRISPR/Cas9 Gene Editing of MIR155HG in Primary Human T Cells to Prevent Acute Graft-Versus-Host Disease
Published in The Journal of immunology (1950) (01-05-2023)“…Abstract Introduction: Acute graft-versus-host disease (GVHD) mediated by donor alloreactive T cells is the leading cause of non-relapse mortality in patients…”
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11
CRISPR/CAS9 Gene Editing of MIR155HG in Primary Human T Cells to Prevent Acute Graft-Versus-Host Disease
Published in Blood (15-11-2022)Get full text
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Abstract 2335: DHODH inhibition modulates T cell metabolism reducing GVHD and prevents relapse following allogeneic HCT
Published in Cancer research (Chicago, Ill.) (15-06-2022)“…Abstract Introduction: The use of allogeneic hematopoietic cell transplantation to treat acute myeloid leukemia (AML) has risen in recent years. However,…”
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