Search Results - "Braun, Molly R"

Mucosal immunization with Ad5-based vaccines protects Syrian hamsters from challenge with omicron and delta variants of SARS-CoV-2 by Braun, Molly R, Martinez, Clarissa I, Dora, Emery G, Showalter, Laura J, Mercedes, Annette R, Tucker, Sean N

“…SARS-CoV-2 variant clades continue to circumvent antibody responses elicited by vaccination or infection. Current parenteral vaccination strategies reduce…”
Get full text

Respiratory syncytial virus M2-1 protein associates non-specifically with viral messenger RNA and with specific cellular messenger RNA transcripts by Braun, Molly R, Noton, Sarah L, Blanchard, Emmeline L, Shareef, Afzaal, Santangelo, Philip J, Johnson, W Evan, Fearns, Rachel

“…Respiratory syncytial virus (RSV) is a major cause of respiratory disease in infants and the elderly. RSV is a non-segmented negative strand RNA virus. The…”
Get full text

Polymerase-tagged respiratory syncytial virus reveals a dynamic rearrangement of the ribonucleocapsid complex during infection by Blanchard, Emmeline L, Braun, Molly R, Lifland, Aaron W, Ludeke, Barbara, Noton, Sarah L, Vanover, Daryll, Zurla, Chiara, Fearns, Rachel, Santangelo, Philip J

“…The ribonucleocapsid complex of respiratory syncytial virus (RSV) is responsible for both viral mRNA transcription and viral replication during infection,…”
Get full text

RNA elongation by respiratory syncytial virus polymerase is calibrated by conserved region V by Braun, Molly R, Deflubé, Laure R, Noton, Sarah L, Mawhorter, Michael E, Tremaglio, Chadene Z, Fearns, Rachel

“…The large polymerase subunit (L) of non-segmented negative strand RNA viruses transcribes viral mRNAs and replicates the viral genome. Studies with VSV have…”
Get full text

Drop the Needle; A Temperature Stable Oral Tablet Vaccine Is Protective against Respiratory Viral Pathogens by Flitter, Becca A, Braun, Molly R, Tucker, Sean N

“…To effectively combat emerging infections and prevent future pandemics, next generation vaccines must be developed quickly, manufactured rapidly, and most…”
Get full text

Elimination of Human Papillomavirus 16-Positive Tumors by a Mucosal rAd5 Therapeutic Vaccination in a Pre-Clinical Murine Study by Braun, Molly R, Moore, Anne C, Lindbloom, Jonathan D, Hodgson, Katherine A, Dora, Emery G, Tucker, Sean N

“…Therapeutic vaccination can harness the body's cellular immune system to target and destroy cancerous cells. Several treatment options are available to…”
Get full text

A Next-Generation Adenoviral Vaccine Elicits Mucosal and Systemic Immunogenicity and Reduces Viral Shedding after SARS-CoV-2 Challenge in Nonhuman Primates by Tedjakusuma, Sarah N, Lester, Colin A, Neuhaus, Elena D, Dora, Emery G, Gutierrez, Samanta, Braun, Molly R, Tucker, Sean N, Flitter, Becca A

“…As new SARS-CoV-2 variants continue to emerge and impact communities worldwide, next-generation vaccines that enhance protective mucosal immunity may have a…”
Get full text

An easy pill to swallow: oral recombinant vaccines for the 21st century by Braun, Molly R, Flitter, Becca A, Sun, William, Tucker, Sean N

“…Oral vaccines have a distinctive advantage of stimulating immune responses in the mucosa, where numerous pathogens gain entry and cause disease. Although…”
Get full text

Mechanism for de novo initiation at two sites in the respiratory syncytial virus promoter by Cressey, Tessa N, Noton, Sarah L, Nagendra, Kartikeya, Braun, Molly R, Fearns, Rachel

“…Abstract The respiratory syncytial virus (RSV) RNA dependent RNA polymerase (RdRp) initiates two RNA synthesis processes from the viral promoter: genome…”
Get full text

Genes and Proteins Involved in qnrS1 Induction by Monárrez, Rubén, Wang, Yin, Fu, Yingmei, Liao, Chun-Hsing, Okumura, Ryo, Braun, Molly R, Jacoby, George A, Hooper, David C

“…Expression of the quinolone resistance gene is increased by quinolones, but unlike induction of some other genes, the bacterial SOS system is not involved and…”
Get full text

Therapeutic efficacy of the small molecule GS-5734 against Ebola virus in rhesus monkeys by Warren, Travis K., Jordan, Robert, Lo, Michael K., Ray, Adrian S., Mackman, Richard L., Soloveva, Veronica, Siegel, Dustin, Perron, Michel, Bannister, Roy, Hui, Hon C., Larson, Nate, Strickley, Robert, Wells, Jay, Stuthman, Kelly S., Van Tongeren, Sean A., Garza, Nicole L., Donnelly, Ginger, Shurtleff, Amy C., Retterer, Cary J., Gharaibeh, Dima, Zamani, Rouzbeh, Kenny, Tara, Eaton, Brett P., Grimes, Elizabeth, Welch, Lisa S., Gomba, Laura, Wilhelmsen, Catherine L., Nichols, Donald K., Nuss, Jonathan E., Nagle, Elyse R., Kugelman, Jeffrey R., Palacios, Gustavo, Doerffler, Edward, Neville, Sean, Carra, Ernest, Clarke, Michael O., Zhang, Lijun, Lew, Willard, Ross, Bruce, Wang, Queenie, Chun, Kwon, Wolfe, Lydia, Babusis, Darius, Park, Yeojin, Stray, Kirsten M., Trancheva, Iva, Feng, Joy Y., Barauskas, Ona, Xu, Yili, Wong, Pamela, Braun, Molly R., Flint, Mike, McMullan, Laura K., Chen, Shan-Shan, Fearns, Rachel, Swaminathan, Swami, Mayers, Douglas L., Spiropoulou, Christina F., Lee, William A., Nichol, Stuart T., Cihlar, Tomas, Bavari, Sina

“…The discovery is reported of a small molecule drug, GS-5734, which has antiviral activity against Ebola virus and other filoviruses, and is capable of…”
Get full text

Multifunctional Roles of the Respiratory Syncytial Virus Transcription and Genome Replication Machinery by Braun, Molly R

“…Respiratory syncytial virus (RSV) is the leading cause of pediatric lower respiratory tract infection and a major cause of hospitalization. The RSV genome is a…”
Get full text