Search Results - "Braun, Kathleen R."

Filamentous Bacteriophage Promote Biofilm Assembly and Function by Secor, Patrick R., Sweere, Johanna M., Michaels, Lia A., Malkovskiy, Andrey V., Lazzareschi, Daniel, Katznelson, Ethan, Rajadas, Jayakumar, Birnbaum, Michael E., Arrigoni, Allison, Braun, Kathleen R., Evanko, Stephen P., Stevens, David A., Kaminsky, Werner, Singh, Pradeep K., Parks, William C., Bollyky, Paul L.

“…Biofilms—communities of bacteria encased in a polymer-rich matrix—confer bacteria with the ability to persist in pathologic host contexts, such as the cystic…”
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Diabetes promotes an inflammatory macrophage phenotype and atherosclerosis through acyl-CoA synthetase 1 by Kanter, Jenny E, Kramer, Farah, Barnhart, Shelley, Averill, Michelle M, Vivekanandan-Giri, Anuradha, Vickery, Thad, Li, Lei O, Becker, Lev, Yuan, Wei, Chait, Alan, Braun, Kathleen R, Potter-Perigo, Susan, Sanda, Srinath, Wight, Thomas N, Pennathur, Subramaniam, Serhan, Charles N, Heinecke, Jay W, Coleman, Rosalind A, Bornfeldt, Karin E

“…The mechanisms that promote an inflammatory environment and accelerated atherosclerosis in diabetes are poorly understood. We show that macrophages isolated…”
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Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs by Chang, Mary Y, Kang, Inkyung, Gale, Jr, Michael, Manicone, Anne M, Kinsella, Michael G, Braun, Kathleen R, Wigmosta, Tara, Parks, William C, Altemeier, William A, Wight, Thomas N, Frevert, Charles W

“…Growing evidence suggests that versican is important in the innate immune response to lung infection. Our goal was to understand the regulation of…”
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Versican Deficiency Significantly Reduces Lung Inflammatory Response Induced by Polyinosine-Polycytidylic Acid Stimulation by Kang, Inkyung, Harten, Ingrid A., Chang, Mary Y., Braun, Kathleen R., Sheih, Alyssa, Nivison, Mary P., Johnson, Pamela Y., Workman, Gail, Kaber, Gernot, Evanko, Stephen P., Chan, Christina K., Merrilees, Mervyn J., Ziegler, Steven F., Kinsella, Michael G., Frevert, Charles W., Wight, Thomas N.

“…Viral infection is an exacerbating factor contributing to chronic airway diseases, such as asthma, via mechanisms that are still unclear…”
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ECM components guide IL-10 producing regulatory T-cell (TR1) induction from effector memory T-cell precursors by Bollyky, Paul L., Wu, Rebecca P., Falk, Ben A., Lord, James D., Long, S. Alice, Preisinger, Anton, Teng, Brandon, Holt, Gregory E., Standifer, Nathan E., Braun, Kathleen R., Xie, Cindy Fang, Samuels, Peter L., Vernon, Robert B., Gebe, John A., Wight, Thomas N., Nepom, Gerald T., Germain, Ron

“…We describe a role for ECM as a biosensor for inflammatory microenvironments that plays a critical role in peripheral immune tolerance. We show that hyaluronan…”
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Expression of V3 Versican by Rat Arterial Smooth Muscle Cells Promotes Differentiated and Anti-inflammatory Phenotypes by Kang, Inkyung, Barth, Jeremy L., Sproul, Erin P., Yoon, Dong Won, Workman, Gail A., Braun, Kathleen R., Argraves, W. Scott, Wight, Thomas N.

“…Arterial smooth muscle cells (ASMCs) undergo phenotypic changes during development and pathological processes in vivo and during cell culture in vitro. Our…”
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Polyinosine-polycytidylic acid stimulates versican accumulation in the extracellular matrix promoting monocyte adhesion by Potter-Perigo, Susan, Johnson, Pamela Y, Evanko, Stephen P, Chan, Christina K, Braun, Kathleen R, Wilkinson, Thomas S, Altman, Leonard C, Wight, Thomas N

“…Viral infections are known to exacerbate asthma and other lung diseases in which chronic inflammatory processes are implicated, but the mechanism is not well…”
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Neointima Formed by Arterial Smooth Muscle Cells Expressing Versican Variant V3 Is Resistant to Lipid and Macrophage Accumulation by Merrilees, Mervyn J, Beaumont, Brent W, Braun, Kathleen R, Thomas, Anita C, Kang, Inkyung, Hinek, Aleksander, Passi, Alberto, Wight, Thomas N

“…OBJECTIVE—Extracellular matrix (ECM) of neointima formed following angioplasty contains elevated levels of versican, loosely arranged collagen, and fragmented…”
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ADAMTS-4 and Biglycan are Expressed at High Levels and Co-Localize to Podosomes During Endothelial Cell Tubulogenesis In Vitro by Obika, Masanari, Vernon, Robert B., Gooden, Michel D., Braun, Kathleen R., Chan, Christina K., Wight, Thomas N.

“…Proteolysis of the extracellular matrix influences vascular growth. We examined the expression of ADAMTS-1, -4, and -5 metalloproteinases and their…”
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Differentiation of cardiomyocytes from human embryonic stem cells is accompanied by changes in the extracellular matrix production of versican and hyaluronan by Chan, Christina K., Rolle, Marsha W., Potter-Perigo, Susan, Braun, Kathleen R., Van Biber, Benjamin P., Laflamme, Michael A., Murry, Charles E., Wight, Thomas N.

“…Proteoglycans and hyaluronan play critical roles in heart development. In this study, human embryonic stem cells (hESC) were used as a model to quantify the…”
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Inhibition of PDGF-B induction and cell growth by syndecan-1 involves the ubiquitin and SUMO-1 ligase, Topors by Braun, Kathleen R, DeWispelaere, Allison M, Bressler, Steven L, Fukai, Nozomi, Kenagy, Richard D, Chen, Lihua, Clowes, Alexander W, Kinsella, Michael G

“…Syndecans are receptors for soluble ligands, including heparin-binding growth factors, and matrix proteins. However, intracellular targets of syndecan-1…”
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Platelet-derived Growth Factor Differentially Regulates the Expression and Post-translational Modification of Versican by Arterial Smooth Muscle Cells through Distinct Protein Kinase C and Extracellular Signal-regulated Kinase Pathways by Cardoso, Luiz E.M., Little, Peter J., Ballinger, Mandy L., Chan, Christina K., Braun, Kathleen R., Potter-Perigo, Susan, Bornfeldt, Karin E., Kinsella, Michael G., Wight, Thomas N.

“…The synthesis of proteoglycans involves steps that regulate both protein and glycosaminoglycan (GAG) synthesis, but it is unclear whether these two pathways…”
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Hyaluronan Accumulation Is Elevated in Cultures of Low Density Lipoprotein Receptor-deficient Cells and Is Altered by Manipulation of Cell Cholesterol Content by Sakr, Sana W., Potter-Perigo, Susan, Kinsella, Michael G., Johnson, Pamela Y., Braun, Kathleen R., Goueffic, Yann, Rosenfeld, Michael E., Wight, Thomas N.

“…The extracellular matrix molecule hyaluronan (HA) accumulates in human atherosclerotic lesions. Yet the reasons for this accumulation have not been adequately…”
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Overexpression of the V3 variant of versican alters arterial smooth muscle cell adhesion, migration, and proliferation in vitro by Lemire, Joan M., Merrilees, Mervyn J., Braun, Kathleen R., Wight, Thomas N.

“…Versican is an extracellular matrix proteoglycan produced by many cells. Although versican is generally known as a large chondroitin sulfate proteoglycan…”
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Filamentous Bacteriophage Produced by Pseudomonas aeruginosa Alters the Inflammatory Response and Promotes Noninvasive Infection In Vivo by Secor, Patrick R, Michaels, Lia A, Smigiel, Kate S, Rohani, Maryam G, Jennings, Laura K, Hisert, Katherine B, Arrigoni, Allison, Braun, Kathleen R, Birkland, Timothy P, Lai, Ying, Hallstrand, Teal S, Bollyky, Paul L, Singh, Pradeep K, Parks, William C

“…Pseudomonas aeruginosa is an important opportunistic human pathogen that lives in biofilm-like cell aggregates at sites of chronic infection, such as those…”
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V3: an enigmatic isoform of the proteoglycan versican by Wight, Thomas N, Day, Anthony J, Kang, Inkyung, Harten, Ingrid A, Kaber, Gernot, Briggs, David C, Braun, Kathleen R, Lemire, Joan M, Kinsella, Michael G, Hinek, Aleksander, Merrilees, Mervyn J

“…V3 is an isoform of the extracellular matrix (ECM) proteoglycan (PG) versican generated through alternative splicing of the versican gene such that the two…”
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Retrovirally Mediated Overexpression of Versican V3 by Arterial Smooth Muscle Cells Induces Tropoelastin Synthesis and Elastic Fiber Formation In Vitro and In Neointima After Vascular Injury by Merrilees, Mervyn J, Lemire, Joan M, Fischer, Jens W, Kinsella, Michael G, Braun, Kathleen R, Clowes, Alexander W, Wight, Thomas N

“…Versican is an extracellular matrix (ECM) proteoglycan that is synthesized as multiple splice variants. In a recent study, we demonstrated that…”
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Expression of Versican V3 by Arterial Smooth Muscle Cells Alters Tumor Growth Factor β (TGFβ)-, Epidermal Growth Factor (EGF)-, and Nuclear Factor κB (NFκB)-dependent Signaling Pathways, Creating a Microenvironment That Resists Monocyte Adhesion by Kang, Inkyung, Yoon, Dong Won, Braun, Kathleen R., Wight, Thomas N.

“…Monocyte/macrophage accumulation plays a critical role during progression of cardiovascular diseases, such as atherosclerosis. Our previous studies…”
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Monocyte-to-macrophage differentiation: synthesis and secretion of a complex extracellular matrix by Chang, Mary Y, Chan, Christina K, Braun, Kathleen R, Green, Pattie S, O'Brien, Kevin D, Chait, Alan, Day, Anthony J, Wight, Thomas N

“…Although monocyte- and macrophage-derived molecules are known to promote extracellular matrix (ECM) disruption and destabilization, it is less appreciated that…”
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The synthesis and secretion of versican isoform V3 by mammalian cells: A role for N-linked glycosylation by Harten, Ingrid A., Kaber, Gernot, Agarwal, Kiran J., Kang, Inkyung, Ibarrientos, Sean Reyes, Workman, Gail, Chan, Christina K., Nivison, Mary P., Nagy, Nadine, Braun, Kathleen R., Kinsella, Michael G., Merrilees, Mervyn J., Wight, Thomas N.

“…Versican is a large extracellular matrix (ECM) chondroitin sulfate (CS) proteoglycan found in most soft tissues, which is encoded by the VCAN gene. At least…”
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