Immunosuppressive effects of soluble factors secreted by head and neck squamous cell carcinoma on dendritic cells and T lymphocytes

Immunosuppressive effects of soluble factors secreted by head and neck squamous cell carcinoma on dendritic cells and T lymphocytes

Recent observations suggest that the inability of the immune system to mount an effective immune response against head and neck squamous cell carcinoma (HNSCC) could be a result of the immunosuppression mediated through soluble factors that are secreted by tumour cells. Therefore, we investigated th...

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Published in:Oral oncology Vol. 39; no. 7; pp. 672 - 679
Main Authors: Kacani, Laco, Wurm, Martin, Schennach, Harald, Braun, Ilona, Andrle, Jan, Sprinzl, Georg M.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-10-2003
Subjects:
Antigen Presentation
Biological Factors - immunology
Carcinoma, Squamous Cell - immunology
Cell Differentiation - immunology
Culture Media, Conditioned
Cytokines
Cytokines - biosynthesis
Dendritic cells
Dendritic Cells - immunology
Head and Neck Neoplasms - immunology
Head and neck squamous cell carcinoma
Humans
Immune Tolerance
Immunosuppression
Interleukin-10 - metabolism
Interleukin-12 - metabolism
Solubility
Soluble factor
T lymphocytes
T-Lymphocytes - immunology
Tumor Cells, Cultured
Tumor Escape - immunology
T lymphocytes
maDC
IL
Soluble factor
Dendritic cells
Cytokines
HNSCC-CM
Treg
PBMC
Immunosuppression
SCC
imDC
IFN-γ
Th
HNSCC
MCM
Head and neck squamous cell carcinoma
TGF-β
DC
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Summary:Recent observations suggest that the inability of the immune system to mount an effective immune response against head and neck squamous cell carcinoma (HNSCC) could be a result of the immunosuppression mediated through soluble factors that are secreted by tumour cells. Therefore, we investigated the effects of conditioned medium obtained from cultures of HNSCC cell lines (HNSCC-CM) on the function of dendritic cells (DC) and T cell immune response. In our study, we could not observe any inhibitory effect of HNSCC-CM on the maturation and the cytokine secretion pattern of DC. On the contrary, HNSCC-CM from two of three cell lines consistently decreased the quantity of IFN-γ- and IL-4-secreting T cells upon restimulation in vitro. In conclusion, our data suggest that soluble factors secreted by HNSCC cells directly inhibit the function of effector T cells, rather than impeding the process of antigen presentation.
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ISSN:1368-8375
1879-0593
DOI:10.1016/S1368-8375(03)00076-9