Search Results - "Braun, Attila"

Zinc Homeostasis in Platelet-Related Diseases by Mammadova-Bach, Elmina, Braun, Attila

“…Zn deficiency in the human population is frequent in underdeveloped countries. Worldwide, approximatively 2 billion people consume Zn -deficient diets,…”
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Platelet-Cancer Interplay: Molecular Mechanisms and New Therapeutic Avenues by Braun, Attila, Anders, Hans-Joachim, Gudermann, Thomas, Mammadova-Bach, Elmina

“…Although platelets are critically involved in thrombosis and hemostasis, experimental and clinical evidence indicate that platelets promote tumor progression…”
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Platelets and Defective N-Glycosylation by Mammadova-Bach, Elmina, Jaeken, Jaak, Gudermann, Thomas, Braun, Attila

“…N-glycans are covalently linked to an asparagine residue in a simple acceptor sequence of proteins, called a sequon. This modification is important for protein…”
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Autocrine and paracrine regulatory functions of platelet serotonin by Mammadova-Bach, Elmina, Mauler, Maximilian, Braun, Attila, Duerschmied, Daniel

“…Platelets serotonin (5-hydroxytrytamine, 5-HT) uptake and storage in dense granules is tightly regulated by the serotonergic transport system in the blood…”
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TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival by Mittermeier, Lorenz, Demirkhanyan, Lusine, Stadlbauer, Benjamin, Breit, Andreas, Recordati, Camilla, Hilgendorff, Anne, Matsushita, Masayuki, Braun, Attila, Simmons, David G., Zakharian, Eleonora, Gudermann, Thomas, Chubanov, Vladimir

“…Zn2+, Mg2+, and Ca2+ are essential minerals required for a plethora of metabolic processes and signaling pathways. Different categories of cation-selective…”
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Extracellular DNA-A Danger Signal Triggering Immunothrombosis by Shi, Chongxu, Yang, Luying, Braun, Attila, Anders, Hans-Joachim

“…Clotting and inflammation are effective danger response patterns positively selected by evolution to limit fatal bleeding and pathogen invasion upon traumatic…”
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Orai1 (CRACM1) is the platelet SOC channel and essential for pathological thrombus formation by Braun, Attila, Varga-Szabo, David, Kleinschnitz, Christoph, Pleines, Irina, Bender, Markus, Austinat, Madeleine, Bösl, Michael, Stoll, Guido, Nieswandt, Bernhard

“…Platelet activation and aggregation at sites of vascular injury are essential for primary hemostasis, but are also major pathomechanisms underlying myocardial…”
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Comparison of the central human and mouse platelet signaling cascade by systems biological analysis by Balkenhol, Johannes, Kaltdorf, Kristin V, Mammadova-Bach, Elmina, Braun, Attila, Nieswandt, Bernhard, Dittrich, Marcus, Dandekar, Thomas

“…Understanding the molecular mechanisms of platelet activation and aggregation is of high interest for basic and clinical hemostasis and thrombosis research…”
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Combined In Vivo Depletion of Glycoprotein VI and C-Type Lectin-Like Receptor 2 Severely Compromises Hemostasis and Abrogates Arterial Thrombosis in Mice by Bender, Markus, May, Frauke, Lorenz, Viola, Thielmann, Ina, Hagedorn, Ina, Finney, Brenda A, Vögtle, Timo, Remer, Katharina, Braun, Attila, Bösl, Michael, Watson, Steve P, Nieswandt, Bernhard

“…OBJECTIVE—Platelet inhibition is a major strategy to prevent acute ischemic cardiovascular and cerebrovascular events, which may, however, be associated with…”
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Crystal Clots as Therapeutic Target in Cholesterol Crystal Embolism by Shi, Chongxu, Kim, Tehyung, Steiger, Stefanie, Mulay, Shrikant R., Klinkhammer, Barbara M., Bäuerle, Tobias, Melica, Maria Elena, Romagnani, Paola, Möckel, Diana, Baues, Maike, Yang, Luying, Brouns, Sanne L.N., Heemskerk, Johan W. M., Braun, Attila, Lammers, Twan, Boor, Peter, Anders, Hans-Joachim

“…Cholesterol crystal embolism can be a life-threatening complication of advanced atherosclerosis. Pathophysiology and molecular targets for treatment are…”
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Loss of Orai2-Mediated Capacitative Ca2+ Entry Is Neuroprotective in Acute Ischemic Stroke by Stegner, David, Hofmann, Sebastian, Schuhmann, Michael K, Kraft, Peter, Herrmann, Alexander M, Popp, Sandy, Höhn, Marlen, Popp, Michael, Klaus, Vanessa, Post, Antonia, Kleinschnitz, Christoph, Braun, Attila, Meuth, Sven G, Lesch, Klaus-Peter, Stoll, Guido, Kraft, Robert, Nieswandt, Bernhard

“…BACKGROUND AND PURPOSE—Ischemic stroke is one of the leading causes of disability and death. The principal goal of acute stroke treatment is the recanalization…”
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STIM2 regulates capacitive Ca2+ entry in neurons and plays a key role in hypoxic neuronal cell death by Berna-Erro, Alejandro, Braun, Attila, Kraft, Robert, Kleinschnitz, Christoph, Schuhmann, Michael K, Stegner, David, Wultsch, Thomas, Eilers, Jens, Meuth, Sven G, Stoll, Guido, Nieswandt, Bernhard

“…Excessive cytosolic calcium ion (Ca(2+)) accumulation during cerebral ischemia triggers neuronal cell death, but the underlying mechanisms are poorly…”
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Extracellular DNA Traps: Origin, Function and Implications for Anti-Cancer Therapies by Mamtimin, Medina, Pinarci, Akif, Han, Chao, Braun, Attila, Anders, Hans-Joachim, Gudermann, Thomas, Mammadova-Bach, Elmina

“…Extracellular DNA may serve as marker in liquid biopsies to determine individual diagnosis and prognosis in cancer patients. Cell death or active release from…”
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TRPM7 Kinase Controls Calcium Responses in Arterial Thrombosis and Stroke in Mice by Gotru, Sanjeev K, Chen, Wenchun, Kraft, Peter, Becker, Isabelle C, Wolf, Karen, Stritt, Simon, Zierler, Susanna, Hermanns, Heike M, Rao, Deviyani, Perraud, Anne-Laure, Schmitz, Carsten, Zahedi, René P, Noy, Peter J, Tomlinson, Michael G, Dandekar, Thomas, Matsushita, Masayuki, Chubanov, Vladimir, Gudermann, Thomas, Stoll, Guido, Nieswandt, Bernhard, Braun, Attila

“…OBJECTIVE—TRPM7 (transient receptor potential cation channel, subfamily M, member 7) is a ubiquitously expressed bifunctional protein comprising a transient…”
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Defects in TRPM7 channel function deregulate thrombopoiesis through altered cellular Mg2+ homeostasis and cytoskeletal architecture by Stritt, Simon, Nurden, Paquita, Favier, Remi, Favier, Marie, Ferioli, Silvia, Gotru, Sanjeev K., van Eeuwijk, Judith M M., Schulze, Harald, Nurden, Alan T., Lambert, Michele P., Turro, Ernest, Burger-Stritt, Stephanie, Matsushita, Masayuki, Mittermeier, Lorenz, Ballerini, Paola, Zierler, Susanna, Laffan, Michael A., Chubanov, Vladimir, Gudermann, Thomas, Nieswandt, Bernhard, Braun, Attila

“…Mg 2+ plays a vital role in platelet function, but despite implications for life-threatening conditions such as stroke or myocardial infarction, the mechanisms…”
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The calcium sensor STIM1 is an essential mediator of arterial thrombosis and ischemic brain infarction by Varga-Szabo, David, Braun, Attila, Kleinschnitz, Christoph, Bender, Markus, Pleines, Irina, Pham, Mirko, Renné, Thomas, Stoll, Guido, Nieswandt, Bernhard

“…Platelet activation and aggregation are essential to limit posttraumatic blood loss at sites of vascular injury but also contributes to arterial thrombosis,…”
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Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival by Chubanov, Vladimir, Ferioli, Silvia, Wisnowsky, Annika, Simmons, David G, Leitzinger, Christin, Einer, Claudia, Jonas, Wenke, Shymkiv, Yuriy, Bartsch, Harald, Braun, Attila, Akdogan, Banu, Mittermeier, Lorenz, Sytik, Ludmila, Torben, Friedrich, Jurinovic, Vindi, van der Vorst, Emiel Pc, Weber, Christian, Yildirim, Önder A, Sotlar, Karl, Schürmann, Annette, Zierler, Susanna, Zischka, Hans, Ryazanov, Alexey G, Gudermann, Thomas

“…Mg regulates many physiological processes and signalling pathways. However, little is known about the mechanisms underlying the organismal balance of Mg …”
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Galectin functions in cancer-associated inflammation and thrombosis by Kruk, Linus, Braun, Attila, Cosset, Erika, Gudermann, Thomas, Mammadova-Bach, Elmina

“…Galectins are carbohydrate-binding proteins that regulate many cellular functions including proliferation, adhesion, migration, and phagocytosis. Increasing…”
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Differentially regulated GPVI ectodomain shedding by multiple platelet–expressed proteinases by Bender, Markus, Hofmann, Sebastian, Stegner, David, Chalaris, Athena, Bösl, Michael, Braun, Attila, Scheller, Jürgen, Rose-John, Stefan, Nieswandt, Bernhard

“…Glycoprotein VI (GPVI) mediates platelet activation on exposed subendothelial collagens at sites of vascular injury and thereby contributes to normal…”
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Critical Role for Stromal Interaction Molecule 1 in Cardiac Hypertrophy by HULOT, Jean-Sébastien, FAUCONNIER, Jeremy, HADRI, Lahouaria, JEONG, Dongtak, MÜHLSTEDT, Silke, SCHMITT, Joachim, BRAUN, Attila, BENARD, Ludovic, SALIBA, Youakim, LAGGERBAUER, Bernhard, NIESWANDT, Bernhard, LACAMPAGNE, Alain, RAMANUJAM, Deepak, HAJJAR, Roger J, LOMPRE, Anne-Marie, ENGELHARDT, Stefan, CHAANINE, Antoine, AUBART, Fleur, SASSI, Yassine, MERKLE, Sabine, CAZORLA, Olivier, OUILLE, Aude, DUPUIS, Morgan

“…Cardiomyocytes use Ca2+ not only in excitation-contraction coupling but also as a signaling molecule promoting, for example, cardiac hypertrophy. It is largely…”
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