Search Results - "Brauers, Karen"

Epigenetic mechanisms underlying arsenic-associated lung carcinogenesis by van Breda, Simone G. J., Claessen, Sandra M. H., Lo, Ken, van Herwijnen, Marcel, Brauers, Karen J. J., Lisanti, Sofia, Theunissen, Daniël H. J., Jennen, Danyel G. J., Gaj, Stan, de Kok, Theo M. C. M., Kleinjans, Jos C. S.

“…Arsenic is an established human carcinogen, but the mechanisms through which it contributes to for instance lung cancer development are still unclear. As…”
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Evaluation of developmental toxicant identification using gene expression profiling in embryonic stem cell differentiation cultures by van Dartel, Dorien A M, Pennings, Jeroen L A, de la Fonteyne, Liset J J, Brauers, Karen J J, Claessen, Sandra, van Delft, Joost H, Kleinjans, Jos C S, Piersma, Aldert H

“…The murine embryonic stem cell test (EST) is an alternative testing method designed to assess potential developmental toxicity of compounds. The implementation…”
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Concentration-dependent gene expression responses to flusilazole in embryonic stem cell differentiation cultures by van Dartel, Dorien A.M., Pennings, Jeroen L.A., de la Fonteyne, Liset J.J., Brauers, Karen J.J., Claessen, Sandra, van Delft, Joost H., Kleinjans, Jos C.S., Piersma, Aldert H.

“…The murine embryonic stem cell test (EST) is designed to evaluate developmental toxicity based on compound-induced inhibition of embryonic stem cell (ESC)…”
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Assessing the Metabolic Competence of Sandwich-Cultured Mouse Primary Hepatocytes by MATHIJS, Karen, KIENHUIS, Anne S, BRAUERS, Karen J. J, JENNEN, Danyel G. J, LAHOZ, Agustin, KLEINJANS, Jos C. S, VAN DELFT, Joost H. M

“…Primary human and rat hepatocyte cultures are well established in vitro systems used in toxicological studies. However, whereas transgenic mouse models provide…”
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Exploiting microRNA and mRNA profiles generated in vitro from carcinogen-exposed primary mouse hepatocytes for predicting in vivo genotoxicity and carcinogenicity by Rieswijk, Linda, Brauers, Karen J J, Coonen, Maarten L J, Jennen, Danyel G J, van Breda, Simone G J, Kleinjans, Jos C S

“…The well-defined battery of in vitro systems applied within chemical cancer risk assessment is often characterised by a high false-positive rate, thus…”
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Evaluating microRNA profiles reveals discriminative responses following genotoxic or non-genotoxic carcinogen exposure in primary mouse hepatocytes by Rieswijk, Linda, Brauers, Karen J J, Coonen, Maarten L J, van Breda, Simone G J, Jennen, Danyel G J, Kleinjans, Jos C S

“…Chemical carcinogenesis can be induced by genotoxic (GTX) or non-genotoxic (NGTX) carcinogens. GTX carcinogens have a well-described mode of action. However,…”
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Time Series Analysis of Benzo[A]Pyrene-Induced Transcriptome Changes Suggests That a Network of Transcription Factors Regulates the Effects on Functional Gene Sets by van Delft, Joost H. M., Mathijs, Karen, Staal, Yvonne C. M., van Herwijnen, Marcel H. M., Brauers, Karen J. J., Boorsma, André, Kleinjans, Jos C. S.

“…Chemical carcinogens may cause a multitude of effects inside cells, thereby affecting transcript levels of genes by direct activation of transcription factors…”
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Dietary flavones and flavonoles are inhibitors of poly(ADP-ribose)polymerase-1 in pulmonary epithelial cells by Geraets, Liesbeth, Moonen, Harald J J, Brauers, Karen, Wouters, Emiel F M, Bast, Aalt, Hageman, Geja J

“…The nuclear enzyme poly(ADP-ribose) polymerase-1 (PARP-1), which was initially known to be highly activated by oxidative stress-induced DNA strand breaks, has…”
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Discrimination for Genotoxic and Nongenotoxic Carcinogens by Gene Expression Profiling in Primary Mouse Hepatocytes Improves with Exposure Time by Mathijs, Karen, Brauers, Karen J. J., Jennen, Danyel G. J., Boorsma, Andre, van Herwijnen, Marcel H. M., Gottschalk, Ralph W. H., Kleinjans, Jos C. S., van Delft, Joost H. M.

“…Assessing the potential carcinogenicity of chemicals for humans represents an ongoing challenge. Chronic rodent bioassays predict human cancer risk at only…”
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Classification of Hepatotoxicants Using HepG2 Cells: A Proof of Principle Study by Van den Hof, Wim F. P. M, Coonen, Maarten L. J, van Herwijnen, Marcel, Brauers, Karen, Wodzig, Will K. W. H, van Delft, Joost H. M, Kleinjans, Jos C. S

“…With the number of new drug candidates increasing every year, there is a need for high-throughput human toxicity screenings. As the liver is the most important…”
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Time-series analysis of gene expression profiles induced by nitrosamides and nitrosamines elucidates modes of action underlying their genotoxicity in human colon cells by Hebels, Dennie G.A.J., Brauers, Karen J.J., van Herwijnen, Marcel H.M., Georgiadis, Panagiotis A., Kyrtopoulos, Soterios A., Kleinjans, Jos C.S., de Kok, Theo M.C.M.

“…► Nitrosamines and nitrosamides differ in their temporal transcriptomic effects. ► Both NOC groups affect pathways related to carcinogenicity but at different…”
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Characterisation of cisplatin-induced transcriptomics responses in primary mouse hepatocytes, HepG2 cells and mouse embryonic stem cells shows conservation of regulating transcription factor networks by Rieswijk, Linda, Lizarraga, Daneida, Brauers, Karen J J, Kleinjans, Jos C S, van Delft, Joost H M

“…The toxic mechanisms of cisplatin have been frequently studied in many species and in vitro cell models. The Netherlands Toxicogenomics Centre focuses on…”
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Development and validation of a modified comet assay to phenotypically assess nucleotide excision repair by Langie, Sabine A.S., Knaapen, Ad M., Brauers, Karen J.J., van Berlo, Damien, van Schooten, Frederik-Jan, Godschalk, Roger W.L.

“…There is an increasing need for simple and reliable approaches to phenotypically assess DNA repair capacities. Therefore, a modification of the alkaline comet…”
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Inhibition of LPS-induced pulmonary inflammation by specific flavonoids by Geraets, Liesbeth, Haegens, Astrid, Brauers, Karen, Haydock, Jane A., Vernooy, Juanita H.J., Wouters, Emiel F.M., Bast, Aalt, Hageman, Geja J.

“…In the present study, the anti-inflammatory effects of the flavonoids flavone, fisetin and tricetin were evaluated in a mouse model of LPS-induced acute…”
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Benzo[a]pyrene-Induced Changes in MicroRNA–mRNA Networks by Lizarraga, Daneida, Gaj, Stan, Brauers, Karen J, Timmermans, Leen, Kleinjans, Jos C, van Delft, Joost H. M

“…Toxicological studies assessing the safety of compounds for humans frequently use in vitro systems to characterize toxic responses in combination with…”
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Elimination of heparin interference during microarray processing of fresh and biobank-archived blood samples by Hebels, Dennie G.A.J., van Herwijnen, Marcel H.M., Brauers, Karen J.J., de Kok, Theo M.C.M., Chalkiadaki, Georgia, Kyrtopoulos, Soterios A., Kleinjans, Jos C.S.

“…In the context of environmental health research, biobank blood samples have recently been identified as suitable for high‐throughput omics analyses enabling…”
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Integrative cross-omics analysis in primary mouse hepatocytes unravels mechanisms of cyclosporin A-induced hepatotoxicity by Van den Hof, Wim F.P.M, Van Summeren, Anke, Lommen, Arjen, Coonen, Maarten L.J, Brauers, Karen, van Herwijnen, Marcel, Wodzig, Will K.W.H, Kleinjans, Jos C.S

“…Abstract The liver is responsible for drug metabolism and drug-induced hepatotoxicity is the most frequent reason for drug withdrawal, indicating that better…”
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Integrating multiple omics to unravel mechanisms of Cyclosporin A induced hepatotoxicity in vitro by Van den Hof, Wim F.P.M., Ruiz-Aracama, Ainhoa, Van Summeren, Anke, Jennen, Danyel G.J., Gaj, Stan, Coonen, Maarten L.J., Brauers, Karen, Wodzig, Will K.W.H., van Delft, Joost H.M., Kleinjans, Jos C.S.

“…•Integrated analyses of transcriptome and metabonome results in relevant pathways.•We could unravel mechanisms underlying Cyclosporin A-induced…”
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Inhibition of acute pulmonary and systemic inflammation by 1,7-dimethylxanthine by Geraets, Liesbeth, Haegens, Astrid, Weseler, Antje R., Brauers, Karen, Vernooy, Juanita H.J., Wouters, Emiel F.M., Bast, Aalt, Hageman, Geja J.

“…The nuclear enzyme poly(ADP-ribose) polymerse-1 (PARP-1) has previously been reported to play an important role in lipopolysaccharide (LPS)-induced pulmonary…”
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Increased mitochondrial ROS formation by acetaminophen in human hepatic cells is associated with gene expression changes suggesting disruption of the mitochondrial electron transport chain by Jiang, Jian, Briedé, Jacob J., Jennen, Danyel G.J., Van Summeren, Anke, Saritas-Brauers, Karen, Schaart, Gert, Kleinjans, Jos C.S., de Kok, Theo M.C.M.

“…•Toxic doses of acetaminophen (APAP) boost the formation of mitochondrial reactive oxygen species (ROS).•Toxic doses of APAP disrupt the expression of many…”
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