Search Results - "Braudeau, J"

Specific targeting of the GABA-A receptor α5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice by Braudeau, J, Delatour, B, Duchon, A, Pereira, P Lopes, Dauphinot, L, de Chaumont, F, Olivo-Marin, J-C, Dodd, RH, Hérault, Y, Potier, M-C

“…An imbalance between inhibitory and excitatory neurotransmission has been proposed to contribute to altered brain function in individuals with Down syndrome…”
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Specific targeting of the GABA-A receptor alpha 5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice by Braudeau, J, Delatour, B, Duchon, A, Pereira, P Lopes, Dauphinot, L, de Chaumont, F, Olivo-Marin, J-C, Dodd, R H, Herault, Y, Potier, M-C

“…An imbalance between inhibitory and excitatory neurotransmission has been proposed to contribute to altered brain function in individuals with Down syndrome…”
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Evaluation of Memantine in AAV-AD Rat: A Model of Late-Onset Alzheimer’s Disease Predementia by Souchet, B., Audrain, M., Alves, S., Fol, R., Tada, S., Orefice, N. S., Potier, B., Dutar, P., Billard, J.-M., Cartier, Nathalie, Braudeau, Jérôme

“…Background Though our understanding of Alzheimer’s disease (AD) remains elusive, it is well known that the disease starts long before the first signs of…”
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Multiomics Blood-Based Biomarkers Predict Alzheimer’s Predementia with High Specificity in a Multicentric Cohort Study by Souchet, B., Michaïl, A., Heuillet, M., Dupuy-Gayral, A., Haudebourg, E., Pech, C., Berthemy, A., Autelitano, F., Billoir, B., Domoto-Reilly, K., Fowler, C., Grabowski, T., Jayadev, S., Masters, C. L., Braudeau, Jérôme

“…Background The primary criteria for diagnosing mild cognitive impairment (MCI) due to Alzheimer’s Disease (AD) or probable mild AD dementia rely partly on…”
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Cerebral Phospho-Tau Acts Synergistically with Soluble Aβ42 Leading to Mild Cognitive Impairment in AAV-AD Rats by Souchet, B., Audrain, M., Gu, Y., Lindberg, M. F., Orefice, N. S., Rey, E., Cartier, N., Janel, N., Meijer, L., Braudeau, Jérôme

“…Background Alzheimer’s disease (AD) is a continuum of events beginning with an increase in brain soluble Aβ342 followed by the appearance of…”
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Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model by Braudeau, J., Dauphinot, L., Duchon, A., Loistron, A., Dodd, R. H., Hérault, Y., Delatour, B., Potier, M. C.

“…Decrease of GABAergic transmission has been proposed to improve memory functions. Indeed, inverse agonists selective for α5 GABA-A-benzodiazepine receptors…”
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S.16.04 A non convulsant alpha5 selective GABA-A inverse agonist restores cognitive deficits in a mouse model of Down syndrome by Delatour, B, Braudeau, J, Duchon, A, Dauphinot, L, Dodd, R.H, Hérault, Y, Potier, M.C

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Erratum to: Cerebral Phospho-Tau Acts Synergistically with Soluble Aβ42 Leading to Mild Cognitive Impairment in AAV-AD Rats by Souchet, B., Audrain, M., Gu, Y., Lindberg, M. F., Orefice, N. S., Rey, E., Cartier, N., Janel, N., Meijer, L., Braudeau, Jérôme

“…The authors would like to draw the reader’s attention to the error in the following article…”
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Reducing GABAergic inhibition restores cognitive functions in a mouse model of Down syndrome by Potier, Marie-Claude, Braudeau, Jérôme, Dauphinot, Luce, Delatour, Benoît

“…Alterations in excitatory-inhibitory balance occur in Down syndrome and could be responsible for cognitive deficits observed through the life of all…”
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Activation Of Proinflammatory Caspases by Cathepsin B in Focal Cerebral Ischemia by Benchoua, Alexandra, Braudeau, Jérôme, Reis, Aurélia, Couriaud, Cécile, Onténiente, Brigitte

“…Cathepsins and caspases are two families of proteases that play pivotal roles in ischemic cell death. This study investigated the existence of a cross-talk…”
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Chronic Treatment with a Promnesiant GABA-A -Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model by Braudeau, J., Dauphinot, L., Duchon, A., Loistron, A., Dodd, R. H., Hérault, Y., Delatour, B., Potier, M. C.

“…Decrease of GABAergic transmission has been proposed to improve memory functions. Indeed, inverse agonists selective for α 5 GABA-A-benzodiazepine receptors (…”
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Specific targeting of the GABA-A receptor [alpha]5 subtype by a selective inverse agonist restores cognitive deficits in Down syndrome mice by Braudeau, J, Delatour, B, Duchon, A, Pereira, P Lopes, Dauphinot, L, de Chaumont, F, Olivo-Marin, J-C, Dodd, RH, Hérault, Y, Potier, M-C

“…An imbalance between inhibitory and excitatory neurotransmission has been proposed to contribute to altered brain function in individuals with Down syndrome…”
Get full text

PTD–XIAP protects against cerebral ischemia by anti-apoptotic and transcriptional regulatory mechanisms by Guégan, Christelle, Braudeau, Jérôme, Couriaud, Cécile, Dietz, Gunnar P.H., Lacombe, Pierre, Bähr, Mathias, Nosten-Bertrand, Marika, Onténiente, Brigitte

“…Caspases play a major role in the infarction process that follows occlusion of cerebral arteries and are important targets for stroke therapy. We have…”
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The mechanisms of cell death in focal cerebral ischemia highlight neuroprotective perspectives by anti-caspase therapy by Onténiente, Brigitte, Couriaud, Cécile, Braudeau, Jérôme, Benchoua, Alexandra, Guégan, Christelle

“…A number of studies have validated the importance of caspase activation in ischemia-induced brain damage. Caspases participate in both the initiation and…”
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Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model by Potier, M. C., Hérault, Y., Dodd, R. H., Delatour, Benoît, Loistron, A., Duchon, A., Braudeau, J., Dauphinot, L.

“…Decrease of GABAergic transmission has been proposed to improve memory functions. Indeed, inverse agonists selective for α5 GABA-A-benzodiazepine receptors…”
Get full text