Search Results - "Bratman, Scott"

Preparation of cfMeDIP-seq libraries for methylome profiling of plasma cell-free DNA by Shen, Shu Yi, Burgener, Justin M., Bratman, Scott V., De Carvalho, Daniel D.

“…Circulating cell-free DNA (cfDNA) comprises small DNA fragments derived from normal and tumor tissue that are released into the bloodstream. Recently,…”
Get full text

Bioactive DNA from extracellular vesicles and particles by Malkin, Ethan Z., Bratman, Scott V.

“…Extracellular vesicles (EVs) and particles (EPs) have recently emerged as active carriers of molecular biomarkers and mediators of intercellular communication…”
Get full text

Senescence, Necrosis, and Apoptosis Govern Circulating Cell-free DNA Release Kinetics by Rostami, Ariana, Lambie, Meghan, Yu, Caberry W., Stambolic, Vuk, Waldron, John N., Bratman, Scott V.

“…The kinetics of circulating cell-free DNA (cfDNA) release may provide a real-time assessment of induced cell death. However, there is a limited understanding…”
Get full text

Circulating tumor DNA and liquid biopsy in oncology by Cescon, David W, Bratman, Scott V, Chan, Steven M, Siu, Lillian L

“…Techniques for analyzing circulating tumor DNA (ctDNA) to detect, characterize and monitor cancer have matured rapidly. An increasing body of clinical evidence…”
Get full text

Isolation of salivary cell-free DNA for cancer detection by Brooks, Patricia J, Malkin, Ethan Z, De Michino, Steven, Bratman, Scott V

“…Saliva is an emerging source of disease biomarkers, particularly for cancers of the head and neck. Although analysis of cell-free DNA (cfDNA) in saliva holds…”
Get full text

Monitoring and adapting cancer treatment using circulating tumor DNA kinetics: Current research, opportunities, and challenges by Sanz-Garcia, Enrique, Zhao, Eric, Bratman, Scott V, Siu, Lillian L

“…Circulating tumor DNA (ctDNA) has emerged as a biomarker with wide-ranging applications in cancer management. While its role in guiding precision medicine in…”
Get full text

The prognostic landscape of genes and infiltrating immune cells across human cancers by Gentles, Andrew J, Newman, Aaron M, Liu, Chih Long, Bratman, Scott V, Feng, Weiguo, Kim, Dongkyoon, Nair, Viswam S, Xu, Yue, Khuong, Amanda, Hoang, Chuong D, Diehn, Maximilian, West, Robert B, Plevritis, Sylvia K, Alizadeh, Ash A

“…A searchable pan-cancer resource generated using data from nearly 18,000 human tumors reveals links between tumor infiltration by particular leukocyte subsets,…”
Get full text

Liquid Biopsy Goes Viral: Next-Generation Sequencing to Enhance HPV Detection by Rostami, Ariana, Bratman, Scott V, Han, Kathy

“…Liquid biopsy approaches for the detection of viral DNA can provide important information for the diagnosis and identification of virally-associated cancers…”
Get full text

Nasopharyngeal Cancer: Molecular Landscape by Bruce, Jeff P, Yip, Kenneth, Bratman, Scott V, Ito, Emma, Liu, Fei-Fei

“…Nasopharyngeal carcinoma (NPC) is a unique epithelial malignancy arising from the superior aspect of the pharyngeal mucosal space, associated with latent…”
Get full text

Pan-cancer analysis of longitudinal metastatic tumors reveals genomic alterations and immune landscape dynamics associated with pembrolizumab sensitivity by Cindy Yang, S. Y., Lien, Scott C., Wang, Ben X., Clouthier, Derek L., Hanna, Youstina, Cirlan, Iulia, Zhu, Kelsey, Bruce, Jeffrey P., El Ghamrasni, Samah, Iafolla, Marco A. J., Oliva, Marc, Hansen, Aaron R., Spreafico, Anna, Bedard, Philippe L., Lheureux, Stephanie, Razak, Albiruni, Speers, Vanessa, Berman, Hal K., Aleshin, Alexey, Haibe-Kains, Benjamin, Brooks, David G., McGaha, Tracy L., Butler, Marcus O., Bratman, Scott V., Ohashi, Pamela S., Siu, Lillian L., Pugh, Trevor J.

“…Serial circulating tumor DNA (ctDNA) monitoring is emerging as a non-invasive strategy to predict and monitor immune checkpoint blockade (ICB) therapeutic…”
Get full text

Radiologic Extranodal Extension Portends Worse Outcome in cN+ TNM-8 Stage I Human Papillomavirus–Mediated Oropharyngeal Cancer by Billfalk-Kelly, Astrid, Yu, Eugene, Su, Jie, O'Sullivan, Brian, Waldron, John, Ringash, Jolie, Bartlett, Eric, Perez-Ordonez, Bayardo, Weinreb, Ilan, Bayley, Andrew, Bratman, Scott V., Cho, John, Giuliani, Meredith, Hope, Andrew, Hosni, Ali, Kim, John, Hansen, Aaron R., de Almeida, John, Tong, Li, Xu, Wei, Huang, Shao Hui

“…To identify adverse radiologic nodal features in cN+ TNM-8 stage I human papillomavirus–related (HPV+) oropharyngeal cancer (OPC). All patients with…”
Get full text

The cell-free DNA methylome captures distinctions between localized and metastatic prostate tumors by Chen, Sujun, Petricca, Jessica, Ye, Wenbin, Guan, Jiansheng, Zeng, Yong, Cheng, Nicholas, Gong, Linsey, Shen, Shu Yi, Hua, Junjie T., Crumbaker, Megan, Fraser, Michael, Liu, Stanley, Bratman, Scott V., van der Kwast, Theodorus, Pugh, Trevor, Joshua, Anthony M., De Carvalho, Daniel D., Chi, Kim N., Awadalla, Philip, Ji, Guoli, Feng, Felix, Wyatt, Alexander W., He, Housheng Hansen

“…Metastatic prostate cancer remains a major clinical challenge and metastatic lesions are highly heterogeneous and difficult to biopsy. Liquid biopsy provides…”
Get full text

Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis by Inoue, Minoru, Nakashima, Ryota, Enomoto, Masahiro, Koike, Yuhki, Zhao, Xiao, Yip, Kenneth, Huang, Shao Hui, Waldron, John N., Ikura, Mitsuhiko, Liu, Fei-Fei, Bratman, Scott V.

“…Neutrophil extracellular traps (NETs) promote cancer metastasis in preclinical models following massive exogenous inflammatory stimuli. It remains unknown…”
Get full text

Integrated digital error suppression for improved detection of circulating tumor DNA by Newman, Aaron M, Lovejoy, Alexander F, Klass, Daniel M, Kurtz, David M, Chabon, Jacob J, Scherer, Florian, Stehr, Henning, Liu, Chih Long, Bratman, Scott V, Say, Carmen, Zhou, Li, Carter, Justin N, West, Robert B, Sledge Jr, George W, Shrager, Joseph B, Loo, Billy W, Neal, Joel W, Wakelee, Heather A, Diehn, Maximilian, Alizadeh, Ash A

“…Circulating tumor DNA is detected with high sensitivity and specificity using molecular barcoding and in silico error correction. High-throughput sequencing of…”
Get full text

FACTERA: a practical method for the discovery of genomic rearrangements at breakpoint resolution by Newman, Aaron M, Bratman, Scott V, Stehr, Henning, Lee, Luke J, Liu, Chih Long, Diehn, Maximilian, Alizadeh, Ash A

“…For practical and robust de novo identification of genomic fusions and breakpoints from targeted paired-end DNA sequencing data, we developed Fusion And…”
Get full text

Sensitive tumour detection and classification using plasma cell-free DNA methylomes by Shen, Shu Yi, Singhania, Rajat, Fehringer, Gordon, Chakravarthy, Ankur, Roehrl, Michael H. A., Chadwick, Dianne, Zuzarte, Philip C., Borgida, Ayelet, Wang, Ting Ting, Li, Tiantian, Kis, Olena, Zhao, Zhen, Spreafico, Anna, Medina, Tiago da Silva, Wang, Yadon, Roulois, David, Ettayebi, Ilias, Chen, Zhuo, Chow, Signy, Murphy, Tracy, Arruda, Andrea, O’Kane, Grainne M., Liu, Jessica, Mansour, Mark, McPherson, John D., O’Brien, Catherine, Leighl, Natasha, Bedard, Philippe L., Fleshner, Neil, Liu, Geoffrey, Minden, Mark D., Gallinger, Steven, Goldenberg, Anna, Pugh, Trevor J., Hoffman, Michael M., Bratman, Scott V., Hung, Rayjean J., De Carvalho, Daniel D.

“…The use of liquid biopsies for cancer detection and management is rapidly gaining prominence 1 . Current methods for the detection of circulating tumour DNA…”
Get full text

Prediction of acute myeloid leukaemia risk in healthy individuals by Abelson, Sagi, Collord, Grace, Ng, Stanley W. K., Weissbrod, Omer, Mendelson Cohen, Netta, Niemeyer, Elisabeth, Barda, Noam, Zuzarte, Philip C., Heisler, Lawrence, Sundaravadanam, Yogi, Luben, Robert, Hayat, Shabina, Wang, Ting Ting, Zhao, Zhen, Cirlan, Iulia, Pugh, Trevor J., Soave, David, Ng, Karen, Latimer, Calli, Hardy, Claire, Raine, Keiran, Jones, David, Hoult, Diana, Britten, Abigail, McPherson, John D., Johansson, Mattias, Mbabaali, Faridah, Eagles, Jenna, Miller, Jessica K., Pasternack, Danielle, Timms, Lee, Krzyzanowski, Paul, Awadalla, Philip, Costa, Rui, Segal, Eran, Bratman, Scott V., Beer, Philip, Behjati, Sam, Martincorena, Inigo, Wang, Jean C. Y., Bowles, Kristian M., Quirós, J. Ramón, Karakatsani, Anna, La Vecchia, Carlo, Trichopoulou, Antonia, Salamanca-Fernández, Elena, Huerta, José M., Barricarte, Aurelio, Travis, Ruth C., Tumino, Rosario, Masala, Giovanna, Boeing, Heiner, Panico, Salvatore, Kaaks, Rudolf, Krämer, Alwin, Sieri, Sabina, Riboli, Elio, Vineis, Paolo, Foll, Matthieu, McKay, James, Polidoro, Silvia, Sala, Núria, Khaw, Kay-Tee, Vermeulen, Roel, Campbell, Peter J., Papaemmanuil, Elli, Minden, Mark D., Tanay, Amos, Balicer, Ran D., Wareham, Nicholas J., Gerstung, Moritz, Dick, John E., Brennan, Paul, Vassiliou, George S., Shlush, Liran I.

“…The incidence of acute myeloid leukaemia (AML) increases with age and mortality exceeds 90% when diagnosed after age 65. Most cases arise without any…”
Get full text

Human papillomavirus integration transforms chromatin to drive oncogenesis by Karimzadeh, Mehran, Arlidge, Christopher, Rostami, Ariana, Lupien, Mathieu, Bratman, Scott V, Hoffman, Michael M

“…Human papillomavirus (HPV) drives almost all cervical cancers and up to 70% of head and neck cancers. Frequent integration into the host genome occurs…”
Get full text

Utilizing circulating tumour DNA in radiation oncology by Rostami, Ariana, Bratman, Scott V.

“…Emerging technologies for detection of circulating tumour DNA (ctDNA) are expanding the possibilities for clinical impact to patients with localized,…”
Get full text

Noninvasive monitoring of diffuse large B-cell lymphoma by immunoglobulin high-throughput sequencing by Kurtz, David M., Green, Michael R., Bratman, Scott V., Scherer, Florian, Liu, Chih Long, Kunder, Christian A., Takahashi, Kazuhiro, Glover, Cynthia, Keane, Colm, Kihira, Shingo, Visser, Brendan, Callahan, Jason, Kong, Katherine A., Faham, Malek, Corbelli, Karen S., Miklos, David, Advani, Ranjana H., Levy, Ronald, Hicks, Rodney J., Hertzberg, Mark, Ohgami, Robert S., Gandhi, Maher K., Diehn, Maximilian, Alizadeh, Ash A.

“…Recent studies have shown limited utility of routine surveillance imaging for diffuse large B-cell lymphoma (DLBCL) patients achieving remission. Detection of…”
Get full text