Search Results - "Brasted, P J"

Role of the hippocampal system in associative learning beyond the spatial domain by Brasted, P. J., Bussey, T. J., Murray, E. A., Wise, S. P.

“…Expert opinion remains divided on the issue of whether the hippocampal system functions exclusively in spatial information processing, e.g. in navigation or in…”
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Medial prefrontal and neostriatal lesions disrupt performance in an operant delayed alternation task in rats by Dunnett, Stephen B, Nathwani, Falguni, Brasted, Peter J

“…An operant version of the classical delayed alternation task is presented and applied to evaluate the effects of bilateral prefrontal and striatal lesions in…”
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The effect of excitotoxic lesions of the pedunculopontine tegmental nucleus on performance of a progressive ratio schedule of reinforcement by Alderson, H.L., Brown, V.J., Latimer, M.P., Brasted, P.J., Robertson, A.H., Winn, P.

“…The pedunculopontine tegmental nucleus has connections with sites in both dorsal and ventral striatum, and a number of studies have suggested that it has a…”
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Behavioural recovery following striatal transplantation : effects of postoperative training and P-zone volume by BRASTED, P. J, WATTS, C, TORRES, E. M, ROBBINS, T. W, DUNNETT, S. B

“…Rats were trained on an operant task and then received striatal lesions and grafts. Grafts were derived either from whole-ganglionic eminences or restricted to…”
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Comparison of learning-related neuronal activity in the dorsal premotor cortex and striatum by Brasted, Peter J., Wise, Steven P.

“…Previous studies have reported learning‐related changes in neuronal activity during conditional visuomotor learning, also known as arbitrary sensorimotor…”
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The morphology, integration, and functional efficacy of striatal grafts differ between cell suspensions and tissue pieces by Watts, C, Brasted, P J, Dunnett, S B

“…In order to develop a surgical protocol for use in clinical trials of striatal transplantation in Huntington's disease (HD), the issues involved in the…”
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Distinct Roles for Striatal Subregions in Mediating Response Processing Revealed by Focal Excitotoxic Lesions by Brasted, Peter J, Robbins, Trevor W, Dunnett, Stephen B

“…This study examined the relative roles of distinct striatal areas in response processing. Rats were trained on a reaction time task that enabled performance on…”
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Striatal lesions produce distinctive impairments in reaction time performance in two different operant chambers by Brasted, Peter J, Döbrössy, Máté D, Robbins, Trevor W, Dunnett, Stephen B

“…The dorsal striatum plays a crucial role in mediating voluntary movement. Excitotoxic striatal lesions in rats have previously been shown to impair the…”
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Unilateral lesions of the medial agranular cortex impair responding on a lateralised reaction time task by Brasted, Peter J, Dunnett, Stephen B, Robbins, Trevor W

“…The present study assessed the behavioural sequalae of unilateral excitotoxic cortical lesions made either in the medial agranular cortex (AGm) or in the…”
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The effect of systemic d-amphetamine on motor versus motivational processes in the rat by BROWN, V. J, BRASTED, P. J, BOWMAN, E. M

“…This study examined the effects of systemic amphetamine in rats performing a reaction time task in which motivation and motor readiness were independently…”
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Embryonic Donor Age and Dissection Influences Striatal Graft Development and Functional Integration in a Rodent Model of Huntington's Disease by Watts, Colin, Brasted, Peter J., Eagle, Dawn M., Dunnett, Stephen B.

“…The method of embryonic dissection and the age of the donor material remain areas of controversy in the preparation of striatal tissue for intrastriatal…”
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Associative Plasticity in Striatal Transplants by Brasted, Peter J., Watts, Colin, Robbins, Trevor W., Dunnett, Stephen B.

“…Striatal lesions disrupt both motor and cognitive performance in rats, many aspects of which can be restored by striatal transplants. Because the normal…”
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Behavioral Recovery After Transplantation Into a Rat Model of Huntington's Disease: Dependence on Anatomical Connectivity and Extensive Postoperative Training by Brasted, Peter J, Watts, Colin, Torres, Eduardo M, Robbins, Trevor W, Dunnett, Stephen B

“…Rats were trained to perform a conditioned stimulus-response task known to be sensitive to striatal damage, after which they received unilateral excitotoxic…”
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Unilateral Lesions of the Dorsal Striatum in Rats Disrupt Responding in Egocentric Space by Brasted, Peter J, Humby, Trevor, Dunnett, Stephen B, Robbins, Trevor W

“…Rats were trained in a specially designed, multichoice operant chamber on a visual choice reaction time task designed to assess performance on each side of the…”
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Conditional Motor Learning in the Nonspatial Domain: Effects of Errorless Learning and the Contribution of the Fornix to One-Trial Learning by Brasted, Peter J, Bussey, Timothy J, Murray, Elisabeth A, Wise, Steven P

“…Conditional motor learning contributes importantly to behavioral flexibility. In previous work, the authors found that fornix transections impaired the ability…”
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Fornix Transection Impairs Conditional Visuomotor Learning in Tasks Involving Nonspatially Differentiated Responses by Brasted, Peter J, Bussey, Timothy J, Murray, Elisabeth A, Wise, Steven P

“…  1 Laboratory of Neuropsychology and   2 Laboratory of Systems Neuroscience, National Institute of Mental Health, Bethesda, Maryland 20892 Brasted, Peter J.,…”
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Behavioral Recovery After Transplantation Into a Rat Model of Huntington's Disease: Dependence on Anatomical Connectivity and Extensive Postoperative Training by Brasted, P J, Watts, C, Torres, E M, Robbins, T W, Dunnett, S B

“…Rats were trained to perform a conditioned stimulus-response task known to be sensitive to striatal damage, after which they received unilateral excitotoxic…”
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Comparison of population activity in the dorsal premotor cortex and putamen during the learning of arbitrary visuomotor mappings by Buch, E R, Brasted, P J, Wise, S P

“…A previous study found that as monkeys learned novel mappings between visual cues and responses, neuronal activity patterns evolved at approximately the same…”
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Prefrontal Cortex Activity Related to Abstract Response Strategies by Genovesio, Aldo, Brasted, Peter J., Mitz, Andrew R., Wise, Steven P.

“…Many monkeys adopt abstract response strategies as they learn to map visual symbols to responses by trial and error. According to the repeat-stay strategy, if…”
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Comparison of population activity in the dorsal premotor cortex and putamen during the learning of arbitrary visuomotor mappings by BUCH, Ethan R, BRASTED, Peter J, WISE, Steven P

“…A previous study found that as monkeys learned novel mappings between visual cues and responses, neuronal activity patterns evolved at approximately the same…”
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