Towards a Better Understanding of Toxin Biosynthesis in Seaweeds

Harmful algal blooms (HABs) represent both ecological and public health hazards in the marine environment. Indeed, some algae can produce metabolites that have negative effects on marine ecosystems and mammals. Kainoid derivatives such as kainic acid (KA) and domoic acid (DA) are considered some of...

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Bibliographic Details
Published in:	Chembiochem : a European journal of chemical biology Vol. 23; no. 16; pp. e202200223 - n/a
Main Authors:	Brassart, Pierre‐Louis, Thomas, Olivier P., Courdavault, Vincent, Papon, Nicolas
Format:	Journal Article
Language:	English
Published:	Germany Wiley Subscription Services, Inc 17-08-2022 Wiley-VCH Verlag
Subjects:	Algae Algal blooms Biosynthesis Domoic acid Environmental hazards Eutrophication evolution Health hazards Kainic acid kainoids Life Sciences Marine ecosystems Marine environment Marine microorganisms Marine organisms Metabolic engineering Metabolites Public health Rhodophyta Seaweeds Toxins Biosynthesis kanoids evolution Algae toxins
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Summary:	Harmful algal blooms (HABs) represent both ecological and public health hazards in the marine environment. Indeed, some algae can produce metabolites that have negative effects on marine ecosystems and mammals. Kainoid derivatives such as kainic acid (KA) and domoic acid (DA) are considered some of the most toxic metabolites of marine origin biosynthesized by a limited number of micro‐ and macroalgae. While recent works have provided the first insights into the biosynthetic route of KA in red algae and DA in diatoms, the DA biosynthetic pathway has remained uncharacterized for red algae. In a recent work, the research groups of Chekan and Moore have not only elucidated the biosynthetic pathway of DA in the red alga Chondria armata but also shed light on its complex evolution among marine species. We discuss here the importance of pursuing active research in this area to gain insights into secondary biosynthetic pathways in marine organisms for diagnostic and metabolic engineering perspectives. Pick and mix: In an impressive new report, the research groups of Chekan and Moore have not only elucidated the biosynthetic pathway of marine toxin domoic acid in the red alga Chondria armata, but also shed light on its complex evolution among marine species. We discuss in this Highlight article the importance of continuing to acquire new data on biosynthetic pathways in marine organisms for both diagnostic and metabolic‐engineering purposes.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	1439-4227 1439-7633
DOI:	10.1002/cbic.202200223