Search Results - "Brass, Anette"

The role of chemokines in hepatitis C virus-mediated liver disease by Brass, Anette, Brenndörfer, Erwin Daniel

“…The hepatitis C virus (HCV) is a global health problem affecting more than 170 million people. A chronic HCV infection is associated with liver fibrosis, liver…”
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Extracellular NAD and ATP: Partners in immune cell modulation by Haag, Friedrich, Adriouch, Sahil, Braß, Anette, Jung, Caroline, Möller, Sina, Scheuplein, Felix, Bannas, Peter, Seman, Michel, Koch-Nolte, Friedrich

“…Extracellular NAD and ATP exert multiple, partially overlapping effects on immune cells. Catabolism of both nucleotides by extracellular enzymes keeps…”
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378 Development of a clinical candidate TCR for mutant KRAS using a high-precision cell-based platform by Pase, Luke, Salter, Hugh, Brass, Anette, Casarrubea, Daniela, Dunst, Josefine, Horta, Sara, Masia-Balague, Miriam, Parrot, Tiphane, Totomi, Athina, Uchtenhagen, Hannes, Wang, Shenqiu, Hill, Ryan, Jarvis, Reagan

“…BackgroundTCR-modified T-cell therapy (TCR-T) is emerging as a treatment option for solid tumours containing mutant KRAS,1–4 an area of great unmet medical…”
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Functional Aspects of Intrahepatic Hepatitis B Virus-specific T Cells Induced by Therapeutic DNA Vaccination super(MT)Open by Brass, Anette, Frelin, Lars, Milich, David R, Sallberg, Matti, Ahlen, Gustaf

“…Current therapies for the hepatitis B virus (HBV), a major cause of severe liver disease, suppress viral replication but replication rebounds if therapy is…”
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A Heterologous Prime/Boost Vaccination Strategy Enhances the Immunogenicity of Therapeutic Vaccines for Hepatitis C Virus by Fournillier, Anne, Frelin, Lars, Jacquier, Emilie, Ahlén, Gustaf, Brass, Anette, Gerossier, Estelle, Holmström, Fredrik, Broderick, Kate E., Sardesai, Niranjan Y., Bonnefoy, Jean-Yves, Inchauspé, Geneviève, Sällberg, Matti

“…Background. We explored the concept of heterologous prime/boost vaccination using 2 therapeutic vaccines currently in clinical development aimed at treating…”
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Differential Regulation of P2X7 Receptor Activation by Extracellular Nicotinamide Adenine Dinucleotide and Ecto-ADP-Ribosyltransferases in Murine Macrophages and T Cells by Hong, Shiyuan, Schwarz, Nicole, Brass, Anette, Seman, Michel, Haag, Friedrich, Koch-Nolte, Friedrich, Schilling, William P, Dubyak, George R

“…Extracellular NAD induces the ATP-independent activation of the ionotropic P2X(7) purinergic receptor (P2X(7)R) in murine T lymphocytes via a novel covalent…”
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Functional Aspects of Intrahepatic Hepatitis B Virus-specific T Cells Induced by Therapeutic DNA Vaccination by Brass, Anette, Frelin, Lars, Milich, David R, Sällberg, Matti, Ahlén, Gustaf

“…Current therapies for the hepatitis B virus (HBV), a major cause of severe liver disease, suppress viral replication but replication rebounds if therapy is…”
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Cleavage of the T cell protein tyrosine phosphatase by the hepatitis C virus nonstructural 3/4A protease induces a Th1 to Th2 shift reversible by ribavirin therapy by Brenndörfer, Erwin Daniel, Brass, Anette, Karthe, Juliane, Ahlén, Gustaf, Bode, Johannes Georg, Sällberg, Matti

“…Ribavirin has proven to be a key component of hepatitis C therapies both involving IFNs and new direct-acting antivirals. The hepatitis C virus-mediated…”
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TCR-redirected human T cells inhibit hepatitis C virus replication: hepatotoxic potential is linked to antigen specificity and functional avidity by Pasetto, Anna, Frelin, Lars, Aleman, Soo, Holmström, Fredrik, Brass, Anette, Ahlén, Gustaf, Brenndörfer, Erwin D, Lohmann, Volker, Bartenschlager, Ralf, Sällberg, Matti, Bertoletti, Antonio, Chen, Margaret

“…Virus-specific CTL with high levels of functional avidity have been associated with viral clearance in hepatitis C virus (HCV) infection and with enhanced…”
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Containing “The Great Houdini” of viruses: Combining direct acting antivirals with the host immune response for the treatment of chronic hepatitis C by Ahlén, Gustaf, Frelin, Lars, Brenndörfer, Erwin Daniel, Brass, Anette, Weiland, Ola, Chen, Margaret, Sällberg, Matti

“…Abstract Presently the development of new therapies for hepatitis C virus (HCV) is rapidly moving forward. Almost every week new data appear on how direct…”
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Lipopolysaccharide, IFN-gamma, and IFN-beta induce expression of the thiol-sensitive ART2.1 Ecto-ADP-ribosyltransferase in murine macrophages by Hong, Shiyuan, Brass, Anette, Seman, Michel, Haag, Friedrich, Koch-Nolte, Friedrich, Dubyak, George R

“…Nicotinamide adenosine dinucleotide (NAD) can act as a modulator of multiple immune and inflammatory responses when released into extracellular compartments…”
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Electroporation: a promising method for the nonviral delivery of DNA vaccines in humans? by Frelin, Lars, Brass, Anette, Ahlén, Gustaf, Brenndörfer, Erwin Daniel, Chen, Margaret, Sällberg, Matti

“…The without a doubt major obstacle for making DNA vaccines a commercial success is delivery. If delivery cannot be made simple, cheap and effective, DNA…”
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A synthetic codon-optimized hepatitis C virus nonstructural 5A DNA vaccine primes polyfunctional CD8+ T cell responses in wild-type and NS5A-transgenic mice by Holmström, Fredrik, Pasetto, Anna, Nähr, Veronica, Brass, Anette, Kriegs, Malte, Hildt, Eberhard, Broderick, Kate E, Chen, Margaret, Ahlén, Gustaf, Frelin, Lars

“…The hepatitis C virus (HCV) nonstructural (NS) 5A protein has been shown to promote viral persistence by interfering with both innate and adaptive immunity. At…”
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Hepatitis C virus non-structural 3/4A protein interferes with intrahepatic interferon-γ production by Brenndörfer, Erwin Daniel, Brass, Anette, Söderholm, Jonas, Frelin, Lars, Aleman, Soo, Bode, Johannes Georg, Sällberg, Matti

“…The non-structural (NS) 3/4A protease/helicase of the hepatitis C virus is known to modulate signalling pathways in the infected hepatocyte by cleaving CARD…”
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Heterologous T cells can help restore function in dysfunctional hepatitis C virus nonstructural 3/4A-specific T cells during therapeutic vaccination by Chen, Antony, Ahlén, Gustaf, Brenndörfer, Erwin D, Brass, Anette, Holmström, Fredrik, Chen, Margaret, Söderholm, Jonas, Milich, David R, Frelin, Lars, Sällberg, Matti

“…The hepatitis C virus (HCV)-specific T cell response in patients with chronic HCV is dysfunctional. In this study, we aimed at restoring immunological function…”
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Generation of T-cell receptors targeting a genetically stable and immunodominant cytotoxic T-lymphocyte epitope within hepatitis C virus non-structural protein 3 by Pasetto, Anna, Frelin, Lars, Brass, Anette, Yasmeen, Anila, Koh, Sarene, Lohmann, Volker, Bartenschlager, Ralf, Magalhaes, Isabelle, Maeurer, Markus, Sällberg, Matti, Chen, Margaret

“…Hepatitis C virus (HCV) is a major cause of severe liver disease, and one major contributing factor is thought to involve a dysfunction of virus-specific…”
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Improving on the Ability of Endogenous Hepatitis B Core Antigen to Prime Cytotoxic T Lymphocytes by Nystroöm, Jessica, Chen, Antony, Frelin, Lars, Ahlén, Gustaf, Koh, Sarene, Brass, Anette, Peterson, Darrell L., Fons, Michael, Milich, David R., Hultgren, Catharina, Sällberg, Matti

“…Hepatitis B virus core antigen (HBcAg) is thought to be a major target for specific cytotoxic T cells (CTLs) in hepatitis B virus infections. A single dose of…”
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differential regulation of P2X7R activation by extracellular NAD in murine macrophages and T cells by Hong, Shiyuan, Brass, Anette, Haag, Friedrich, Koch‐Nolte, Friedrich, Dubyak, George

“…Abstract only The ATP‐gated P2X7 receptor (P2X7R) plays important roles in pro‐inflammatory responses. Recently, extracellular NAD has been shown to induce…”
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Basal and inducible expression of the thiol-sensitive ART2.1 ecto-ADP-ribosyltransferase in myeloid and lymphoid leukocytes by Hong, Shiyuan, Brass, Anette, Seman, Michel, Haag, Friedrich, Koch-Nolte, Friedrich, Dubyak, George R.

“…ADP-ribosylation of cell surface proteins in mammalian cells is a post-translational modification by which ecto-ADP-ribosyltransferases (ARTs) transfer…”
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Differential regulation of P2X7 receptor activation by extracellular NAD and ecto-ARTs in murine macrophages and T cells by Hong, Shiyuan, Schwarz, Nicole, Brass, Anette, Seman, Michel, Haag, Friedrich, Koch-Nolte, Friedrich, Schilling, William P., Dubyak, George R.

“…Extracellular NAD induces the ATP-independent activation of the ionotropic P2X7 purinergic receptor (P2X7R) in murine T lymphocytes via a novel covalent…”
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