Search Results - "Brass, Abraham L."

IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion by Desai, Tanay M, Marin, Mariana, Chin, Christopher R, Savidis, George, Brass, Abraham L, Melikyan, Gregory B

“…Interferon-induced transmembrane proteins (IFITMs) inhibit infection of diverse enveloped viruses, including the influenza A virus (IAV) which is thought to…”
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The IFITMs Inhibit Zika Virus Replication by Savidis, George, Perreira, Jill M., Portmann, Jocelyn M., Meraner, Paul, Guo, Zhiru, Green, Sharone, Brass, Abraham L.

“…Zika virus has emerged as a severe health threat with a rapidly expanding range. The IFITM family of restriction factors inhibits the replication of a broad…”
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Identification of Zika Virus and Dengue Virus Dependency Factors using Functional Genomics by Savidis, George, McDougall, William M., Meraner, Paul, Perreira, Jill M., Portmann, Jocelyn M., Trincucci, Gaia, John, Sinu P., Aker, Aaron M., Renzette, Nicholas, Robbins, Douglas R., Guo, Zhiru, Green, Sharone, Kowalik, Timothy F., Brass, Abraham L.

“…The flaviviruses dengue virus (DENV) and Zika virus (ZIKV) are severe health threats with rapidly expanding ranges. To identify the host cell dependencies of…”
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Frizzled proteins are colonic epithelial receptors for C. difficile toxin B by Tao, Liang, Zhang, Jie, Meraner, Paul, Tovaglieri, Alessio, Wu, Xiaoqian, Gerhard, Ralf, Zhang, Xinjun, Stallcup, William B., Miao, Ji, He, Xi, Hurdle, Julian G., Breault, David T., Brass, Abraham L., Dong, Min

“…Clostridium difficile toxin B (TcdB) is a critical virulence factor that causes diseases associated with C. difficile infection. Here we carried out…”
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Frequent Loss of IRF2 in Cancers Leads to Immune Evasion through Decreased MHC Class I Antigen Presentation and Increased PD-L1 Expression by Kriegsman, Barry A, Vangala, Pranitha, Chen, Benjamin J, Meraner, Paul, Brass, Abraham L, Garber, Manuel, Rock, Kenneth L

“…To arise and progress, cancers need to evade immune elimination. Consequently, progressing tumors are often MHC class I (MHC-I) low and express immune…”
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IFITMs Restrict the Replication of Multiple Pathogenic Viruses by Perreira, Jill M., Chin, Christopher R., Feeley, Eric M., Brass, Abraham L.

“…The interferon-inducible transmembrane protein (IFITM) family inhibits a growing number of pathogenic viruses, among them influenza A virus, dengue virus,…”
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Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen by Brass, Abraham L, Dykxhoorn, Derek M, Benita, Yair, Yan, Nan, Engelman, Alan, Xavier, Ramnik J, Lieberman, Judy, Elledge, Stephen J

“…HIV-1 exploits multiple host proteins during infection. We performed a large-scale small interfering RNA screen to identify host factors required by HIV-1 and…”
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The IFITM Proteins Mediate Cellular Resistance to Influenza A H1N1 Virus, West Nile Virus, and Dengue Virus by Brass, Abraham L., Huang, I-Chueh, Benita, Yair, John, Sinu P., Krishnan, Manoj N., Feeley, Eric M., Ryan, Bethany J., Weyer, Jessica L., van der Weyden, Louise, Fikrig, Erol, Adams, David J., Xavier, Ramnik J., Farzan, Michael, Elledge, Stephen J.

“…Influenza viruses exploit host cell machinery to replicate, resulting in epidemics of respiratory illness. In turn, the host expresses antiviral restriction…”
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Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration by Chin, Christopher R., Perreira, Jill M., Savidis, George, Portmann, Jocelyn M., Aker, Aaron M., Feeley, Eric M., Smith, Miles C., Brass, Abraham L.

“…Direct visualization of HIV-1 replication would improve our understanding of the viral life cycle. We adapted established technology and reagents to develop an…”
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Reactivation of Latent HIV-1 by Inhibition of BRD4 by Zhu, Jian, Gaiha, Gaurav D., John, Sinu P., Pertel, Thomas, Chin, Christopher R., Gao, Geng, Qu, Hongjing, Walker, Bruce D., Elledge, Stephen J., Brass, Abraham L.

“…HIV-1 depends on many host factors for propagation. Other host factors, however, antagonize HIV-1 and may have profound effects on viral activation. Curing…”
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genome-wide genetic screen for host factors required for hepatitis C virus propagation by Li, Qisheng, Brass, Abraham L, Ng, Aylwin, Hu, Zongyi, Xavier, Ramnik J, Liang, T. Jake, Elledge, Stephen J

“…Hepatitis C virus (HCV) infection is a major cause of end-stage liver disease and a leading indication for liver transplantation. Current therapy fails in many…”
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Interferon-induced transmembrane protein 3 blocks fusion of sensitive but not resistant viruses by partitioning into virus-carrying endosomes by Suddala, Krishna C, Lee, Christine C, Meraner, Paul, Marin, Mariana, Markosyan, Ruben M, Desai, Tanay M, Cohen, Fredric S, Brass, Abraham L, Melikyan, Gregory B

“…Late endosome-resident interferon-induced transmembrane protein 3 (IFITM3) inhibits fusion of diverse viruses, including Influenza A virus (IAV), by a poorly…”
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IFITM3 inhibits influenza A virus infection by preventing cytosolic entry by Feeley, Eric M, Sims, Jennifer S, John, Sinu P, Chin, Christopher R, Pertel, Thomas, Chen, Li-Mei, Gaiha, Gaurav D, Ryan, Bethany J, Donis, Ruben O, Elledge, Stephen J, Brass, Abraham L

“…To replicate, viruses must gain access to the host cell's resources. Interferon (IFN) regulates the actions of a large complement of interferon effector genes…”
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Distinct patterns of IFITM-mediated restriction of filoviruses, SARS coronavirus, and influenza A virus by Huang, I-Chueh, Bailey, Charles C, Weyer, Jessica L, Radoshitzky, Sheli R, Becker, Michelle M, Chiang, Jessica J, Brass, Abraham L, Ahmed, Asim A, Chi, Xiaoli, Dong, Lian, Longobardi, Lindsay E, Boltz, Dutch, Kuhn, Jens H, Elledge, Stephen J, Bavari, Sina, Denison, Mark R, Choe, Hyeryun, Farzan, Michael

“…Interferon-inducible transmembrane proteins 1, 2, and 3 (IFITM1, 2, and 3) are recently identified viral restriction factors that inhibit infection mediated by…”
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The CD225 Domain of IFITM3 Is Required for both IFITM Protein Association and Inhibition of Influenza A Virus and Dengue Virus Replication by John, Sinu P, Chin, Christopher R, Perreira, Jill M, Feeley, Eric M, Aker, Aaron M, Savidis, George, Smith, Sarah E, Elia, Andrew E H, Everitt, Aaron R, Vora, Mehul, Pertel, Thomas, Elledge, Stephen J, Kellam, Paul, Brass, Abraham L

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Dysfunctional HIV-Specific CD8+ T Cell Proliferation Is Associated with Increased Caspase-8 Activity and Mediated by Necroptosis by Gaiha, Gaurav D., McKim, Kevin J., Woods, Matthew, Pertel, Thomas, Rohrbach, Janine, Barteneva, Natasha, Chin, Christopher R., Liu, Dongfang, Soghoian, Damien Z., Cesa, Kevin, Wilton, Shannon, Waring, Michael T., Chicoine, Adam, Doering, Travis, Wherry, E. John, Kaufmann, Daniel E., Lichterfeld, Mathias, Brass, Abraham L., Walker, Bruce D.

“…Decreased HIV-specific CD8+ T cell proliferation is a hallmark of chronic infection, but the mechanisms of decline are unclear. We analyzed gene expression…”
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Amphotericin B Increases Influenza A Virus Infection by Preventing IFITM3-Mediated Restriction by Lin, Tsai-Yu, Chin, Christopher R., Everitt, Aaron R., Clare, Simon, Perreira, Jill M., Savidis, George, Aker, Aaron M., John, Sinu P., Sarlah, David, Carreira, Erick M., Elledge, Stephen J., Kellam, Paul, Brass, Abraham L.

“…The IFITMs inhibit influenza A virus (IAV) replication in vitro and in vivo. Here, we establish that the antimycotic heptaen, amphotericin B (AmphoB),…”
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ADAM9 promotes type I interferon-mediated innate immunity during encephalomyocarditis virus infection by Bazzone, Lindsey E., Zhu, Junji, King, Michael, Liu, GuanQun, Guo, Zhiru, MacKay, Christopher R., Kyawe, Pyae P., Qaisar, Natasha, Rojas-Quintero, Joselyn, Owen, Caroline A., Brass, Abraham L., McDougall, William, Baer, Christina E., Cashman, Timothy, Trivedi, Chinmay M., Gack, Michaela U., Finberg, Robert W., Kurt-Jones, Evelyn A.

“…Viral myocarditis, an inflammatory disease of the heart, causes significant morbidity and mortality. Type I interferon (IFN)-mediated antiviral responses…”
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RNASEK Is a V-ATPase-Associated Factor Required for Endocytosis and the Replication of Rhinovirus, Influenza A Virus, and Dengue Virus by Perreira, Jill M., Aker, Aaron M., Savidis, George, Chin, Christopher R., McDougall, William M., Portmann, Jocelyn M., Meraner, Paul, Smith, Miles C., Rahman, Motiur, Baker, Richard E., Gauthier, Annick, Franti, Michael, Brass, Abraham L.

“…Human rhinovirus (HRV) causes upper respiratory infections and asthma exacerbations. We screened multiple orthologous RNAi reagents and identified host…”
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TNPO3 Is Required for HIV-1 Replication after Nuclear Import but prior to Integration and Binds the HIV-1 Core by VALLE-CASUSO, Jose Carlos, DI NUNZIO, Francesca, YANG YANG, RESZKA, Natalia, LIENLAF, Maritza, ARHEL, Nathalie, PEREZ, Patricio, BRASS, Abraham L, DIAZ-GRIFFERO, Felipe

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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