Search Results - "Brasky, Kathleen"

GS-9620, an Oral Agonist of Toll-Like Receptor-7, Induces Prolonged Suppression of Hepatitis B Virus in Chronically Infected Chimpanzees by Lanford, Robert E, Guerra, Bernadette, Chavez, Deborah, Giavedoni, Luis, Hodara, Vida L, Brasky, Kathleen M, Fosdick, Abigail, Frey, Christian R, Zheng, Jim, Wolfgang, Grushenka, Halcomb, Randall L, Tumas, Daniel B

“…Background & Aims Direct-acting antiviral agents suppress hepatitis B virus (HBV) load, but they require life-long use. Stimulation of the innate immune system…”
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Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis by Schaal, Justin B, Tran, Dat, Tran, Patti, Ösapay, George, Trinh, Katie, Roberts, Kevin D, Brasky, Kathleen M, Tongaonkar, Prasad, Ouellette, André J, Selsted, Michael E

“…Theta-defensins (θ-defensins) are macrocyclic antimicrobial peptides expressed in leukocytes of Old World monkeys. The peptides are broad spectrum microbicides…”
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Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA by Lanford, Robert E, Feng, Zongdi, Chavez, Deborah, Guerra, Bernadette, Brasky, Kathleen M, Zhou, Yan, Yamane, Daisuke, Perelson, Alan S, Walker, Christopher M, Lemon, Stanley M

“…Hepatitis A virus (HAV) is an hepatotropic human picornavirus that is associated only with acute infection. Its pathogenesis is not well understood because…”
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Dominance of the CD4(+) T helper cell response during acute resolving hepatitis A virus infection by Zhou, Yan, Callendret, Benoît, Xu, Dan, Brasky, Kathleen M, Feng, Zongdi, Hensley, Lucinda L, Guedj, Jeremie, Perelson, Alan S, Lemon, Stanley M, Lanford, Robert E, Walker, Christopher M

“…Hepatitis A virus (HAV) infection typically resolves within 4-7 wk but symptomatic relapse occurs in up to 20% of cases. Immune mechanisms that terminate acute…”
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Intrahepatic Gene Expression during Chronic Hepatitis C Virus Infection in Chimpanzees by BIGGER, Catherine B, GUERRA, Bernadette, BRASKY, Kathleen M, HUBBARD, Gene, BEARD, Michael R, LUXON, Bruce A, LEMON, Stanley M, LANFORD, Robert E

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Experimental cross-species infection of common marmosets by titi monkey adenovirus by Yu, Guixia, Yagi, Shigeo, Carrion, Jr, Ricardo, Chen, Eunice C, Liu, Maria, Brasky, Kathleen M, Lanford, Robert E, Kelly, Kristi R, Bales, Karen L, Schnurr, David P, Canfield, Don R, Patterson, Jean L, Chiu, Charles Y

“…Adenoviruses are DNA viruses that infect a number of vertebrate hosts and are associated with both sporadic and epidemic disease in humans. We previously…”
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Quantification of hair cortisol concentration in common marmosets (Callithrix jacchus) and tufted capuchins (Cebus apella) by Phillips, Kimberley A., Tukan, Alyson N., Rigodanzo, Anna D., Reusch, Ryan T., Brasky, Kathleen M., Meyer, Jerrold S.

“…Quantifying cortisol concentration in hair is a non‐invasive biomarker of long‐term hypothalamic‐pituitary‐adrenal (HPA) activation, and thus can provide…”
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Bioengineered human and allogeneic pulmonary valve conduits chronically implanted orthotopically in baboons: Hemodynamic performance and immunologic consequences by Hopkins, Richard A., MD, Bert, Arthur A., MD, Hilbert, Stephen L., PhD, MD, Quinn, Rachael W., PhD, Brasky, Kathleen M., VMD, Drake, William B., MD, Lofland, Gary K., MD

“…Objective This study assesses in a baboon model the hemodynamics and human leukocyte antigen immunogenicity of chronically implanted bioengineered…”
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Cellular Immune Responses against Simian T-Lymphotropic Virus Type 1 Target Tax in Infected Baboons by Castro, Iris, Giret, Teresa M, Magnani, Diogo M, Maxwell, Helen S, Umland, Oliver, Perry, Jessica K, Pecotte, Jerilyn K, Brasky, Kathleen M, Barber, Glen N, Desrosiers, Ronald C, Watkins, David I

“…There are currently 5 million to 10 million human T-lymphotropic virus type 1 (HTLV-1)-infected people, and many of them will develop severe complications…”
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Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates by Lukashevich, Igor S, Carrion, Ricardo, Salvato, Maria S, Mansfield, Keith, Brasky, Kathleen, Zapata, Juan, Cairo, Cristiana, Goicochea, Marco, Hoosien, Gia E, Ticer, Anysha, Bryant, Joseph, Davis, Harry, Hammamieh, Rasha, Mayda, Maria, Jett, Marti, Patterson, Jean

“…Abstract A single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in…”
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Efficacy of an inactivated Zika vaccine against virus infection during pregnancy in mice and marmosets by Kim, In-Jeong, Lanthier, Paula A., Clark, Madeline J., De La Barrera, Rafael A., Tighe, Michael P., Szaba, Frank M., Travis, Kelsey L., Low-Beer, Timothy C., Cookenham, Tres S., Lanzer, Kathleen G., Bernacki, Derek T., Johnson, Lawrence L., Schneck, Amanda A., Ross, Corinna N., Tardif, Suzette D., Layne-Colon, Donna, Mdaki, Stephanie D., Dick, Edward J., Chuba, Colin, Gonzalez, Olga, Brasky, Kathleen M., Dutton, John, Rutherford, Julienne N., Coffey, Lark L., Singapuri, Anil, Martin, Claudia Sanchez San, Chiu, Charles Y., Thomas, Stephen J., Modjarrad, Kayvon, Patterson, Jean L., Blackman, Marcia A.

“…Zika virus (ZIKV) is a mosquito-borne arbovirus that can cause severe congenital birth defects. The utmost goal of ZIKV vaccines is to prevent both…”
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Protective efficacy of a Zika purified inactivated virus vaccine candidate during pregnancy in marmosets by Kim, In-Jeong, Gonzalez, Olga, Tighe, Michael P., Lanthier, Paula A., Clark, Madeline J., Travis, Kelsey L., Low-Beer, Timothy C., Lanzer, Kathleen G., Bernacki, Derek T., Szaba, Frank M., De La Barrera, Rafael A., Dussupt, Vincent, Mendez-Rivera, Letzibeth, Krebs, Shelly J., Ross, Corinna N., Mdaki, Stephanie D., Brasky, Kathleen M., Layne-Colon, Donna, Tardif, Suzette D., Thomas, Stephen J., Modjarrad, Kayvon, Blackman, Marcia A., Patterson, Jean L.

“…Zika virus (ZIKV) infection during pregnancy poses significant threats to maternal and fetal health, leading to intrauterine fetal demise and severe…”
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Cross-Genotype Immunity to Hepatitis C Virus by LANFORD, Robert E, GUERRA, Bernadette, CHAVEZ, Deborah, BIGGER, Catherine, BRASKY, Kathleen M, WANG, Xiao-Hong, RAY, Stuart C, THOMAS, David L

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Lack of response to exogenous interferon‐α in the liver of chimpanzees chronically infected with hepatitis C virus by Lanford, Robert E., Guerra, Bernadette, Bigger, Catherine B., Lee, Helen, Chavez, Deborah, Brasky, Kathleen M.

“…The mechanism of the interferon‐alpha (IFNα)–induced antiviral response is not completely understood. We recently examined the transcriptional response to IFNα…”
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Lassa Virus Infection in Experimentally Infected Marmosets: Liver Pathology and Immunophenotypic Alterations in Target Tissues by CARRION, Ricardo, BRASKY, Kathleen, MANSFIELD, Keith, JOHNSON, Curtis, GONZALES, Monica, TICER, Anysha, LUKASHEVICH, Igor, TARDIF, Suzette, PATTERSON, Jean

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Protection against lethal challenge by Ebola virus-like particles produced in insect cells by Sun, Yuliang, Carrion, Ricardo, Ye, Ling, Wen, Zhiyuan, Ro, Young-Tae, Brasky, Kathleen, Ticer, Anysha E, Schwegler, E. Ellen, Patterson, Jean L, Compans, Richard W, Yang, Chinglai

“…Abstract Ebola virus-like particles (VLPs) were produced in insect cells using a recombinant baculovirus expression system and their efficacy for protection…”
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Genomic response to interferon-α in chimpanzees : Implications of rapid downregulation for hepatitis C kinetics by LANFORD, Robert E, GUERRA, Bernadette, LEE, Helen, CHAVEZ, Deborah, BRASKY, Kathleen M, BIGGER, Catherine B

“…The mechanism of the interferon-alpha (IFN-alpha)-induced antiviral response during hepatitis C virus (HCV) therapy is n o t completely understood. In this…”
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Woolly Monkey–HBV Infection in Squirrel Monkeys as a Surrogate Nonhuman Primate Model of HBV Infection by Chen, Christopher Y., Winer, Benjamin Y., Chavez, Deborah, Guerra, Bernadette, Brasky, Kathleen M., Eng, Stacey, Salas, Eduardo, Tam, Danny, Simmons, Joe H., Abee, Christian R., Delaney, William E., Ploss, Alexander, Lanford, Robert E., Voitenleitner, Christian

“…Development of curative therapies for chronic hepatitis B virus (HBV) infection will likely require new animal models. Here, we evaluate HBV infection in…”
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Author Correction: Efficacy of an inactivated Zika vaccine against virus infection during pregnancy in mice and marmosets by Kim, In-Jeong, Lanthier, Paula A., Clark, Madeline J., De La Barrera, Rafael A., Tighe, Michael P., Szaba, Frank M., Travis, Kelsey L., Low-Beer, Timothy C., Cookenham, Tres S., Lanzer, Kathleen G., Bernacki, Derek T., Johnson, Lawrence L., Schneck, Amanda A., Ross, Corinna N., Tardif, Suzette D., Layne-Colon, Donna, Mdaki, Stephanie D., Dick, Edward J., Chuba, Colin, Gonzalez, Olga, Brasky, Kathleen M., Dutton, John, Rutherford, Julienne N., Coffey, Lark L., Singapuri, Anil, Martin, Claudia Sanchez San, Chiu, Charles Y., Thomas, Stephen J., Modjarrad, Kayvon, Patterson, Jean L., Blackman, Marcia A.

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The Marmoset Model of GB Virus B Infections: Adaptation to Host Phenotypic Variation by WEATHERFORD, Trudie, CHAVEZ, Deborah, BRASKY, Kathleen M, LANFORD, Robert E

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