Search Results - "Brasch, Nicola E"

Vitamin B12 protects against superoxide-induced cell injury in human aortic endothelial cells by Moreira, Edward S., Brasch, Nicola E., Yun, June

“…Superoxide (O2•−) is implicated in inflammatory states including arteriosclerosis and ischemia–reperfusion injury. Cobalamin (Cbl) supplementation is…”
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Developing Photoactive Coumarin-Caged N -Hydroxysulfonamides for Generation of Nitroxyl (HNO) by Rahman, Mohammad S, Bharadwaj, Vinay, Lautaha, Anau K H S, Sampson, Paul, Brasch, Nicola E, Seed, Alexander J

“…Photoactive -hydroxysulfonamides photocaged with the (6-bromo-7-hydroxycoumarin-4-yl)methyl chromophore have been successfully synthesized, and the mechanisms…”
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Rapid Photoactivated Generation of Nitroxyl (HNO) under Neutral pH Conditions by Zhou, Yang, Cink, Ruth B., Dassanayake, Rohan S., Seed, Alexander J., Brasch, Nicola E., Sampson, Paul

“…Directly obtaining kinetic and mechanistic data for the reactions of nitroxyl (HNO) with biomolecules (k≈103–107 m−1 s−1) is not feasible for many systems…”
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Mechanistic Studies on the Reaction between R2N-NONOates and Aquacobalamin: Evidence for Direct Transfer of a Nitroxyl Group from R2N-NONOates to Cobalt(III) Centers by Hassanin, Hanaa A., Hannibal, Luciana, Jacobsen, Donald W., El-Shahat, Mohamed F., Hamza, Mohamed S. A., Brasch, Nicola E.

“…Tales of the unexpected: Transfer of a nitroxyl group from R2N‐NONOates to aquacobalamin to form nitroxylcobalamin does not proceed via H+‐catalyzed…”
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Nitroxylcob(III)alamin: Synthesis and X-ray Structural Characterization by Hannibal, Luciana, Smith, Clyde A., Jacobsen, Donald W., Brasch, Nicola E.

“…Mystery solved: The long‐elusive crystal structure of nitrosylcobalamin (NOCbl) reveals that the Co‐N‐O angle is 117.4–121.4°; hence, NOCbl is best described…”
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Exploring the potential of the vitamin B12 derivative azidocobalamin to undergo Huisgen 1,3-dipolar azide-alkyne cycloaddition reactions by Stackpole, Ben J., Fredericksen, Jessica M., Brasch, Nicola E.

“…There is considerable interest in using the metalloprotein cofactor vitamin B12 as a vehicle to deliver drugs and diagnostic agents into mammalian or bacterial…”
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Mechanistic Studies on the Reaction of Nitroxylcobalamin with Dioxygen: Evidence for Formation of a Peroxynitritocob(III)alamin Intermediate by Subedi, Harishchandra, Brasch, Nicola E

“…Studies by others suggest that the reduced vitamin B12 complex, cob(II)alamin, scavenges nitric oxide to form air-sensitive nitroxylcobalamin (NO–-Cbl(III);…”
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Mechanistic studies of the reactions of the reduced vitamin B12 derivatives with the HNO donor Piloty's acid: further evidence for oxidation of cob(I)alamin by (H)NO by Subedi, Harishchandra, Brasch, Nicola E

“…There is accumulating evidence for the existence of HNO in biological systems. Compared with NO (˙NO), much less is known about the chemical and biochemical…”
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A simple, convenient method to synthesize cobalamins: synthesis of homocysteinylcobalamin, N-acetylcysteinylcobalamin, 2-N-acetylamino-2-carbomethoxyethanethiolatocobalamin, sulfitocobalamin and nitrocobalamin by Suarez-Moreira, Edward, Hannibal, Luciana, Smith, Clyde A, Chavez, Roberto A, Jacobsen, Donald W, Brasch, Nicola E

“…Glutathionylcobalamin, nitrocobalamin and sulfitocobalamin are important cobalamin metabolites isolable from human tissues. Herein we demonstrate that a…”
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Exploring the Potential of 2‑(2-Nitrophenyl)ethyl-Caged N‑Hydroxysulfonamides for the Photoactivated Release of Nitroxyl (HNO) by Bharadwaj, Vinay, Rahman, Mohammad S, Sampson, Paul, Seed, Alexander J, Brasch, Nicola E

“…The emergence of nitroxyl (HNO) as a biological signaling molecule is attracting increasing attention. HNO-based prodrugs show considerable potential in…”
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Studies on the Reaction of Reduced Vitamin B12 Derivatives with the Nitrosyl ­Hydride (HNO) Donor Angeli's Salt: HNO Oxidizes the Transition-Metal Center of Cob(I)alamin by Subedi, Harishchandra, Brasch, Nicola E.

“…Although it is well established that nitrosyl hydride (nitroxyl, HNO) reduces transition metals including transition‐metal centers of porphyrins and…”
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Mechanistic Studies on the Reaction between Aquacobalamin and the HNO Donor Piloty’s Acid over a Wide pH Range in Aqueous Solution by Polaczek, Justyna, Subedi, Harishchandra, Orzeł, Łukasz, Lisboa, Lynn S, Cink, Ruth B, Stochel, Grażyna, Brasch, Nicola E, van Eldik, Rudi

“…Detailed kinetic and mechanistic studies have been carried out on the reaction between aquacobalamin/hydroxocobalamin (CblOH2 +/CblOH) and nitroxyl (HNO)…”
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Changes in Methionine Metabolism and Histone H3 Trimethylation Are Linked to Mitochondrial Defects in Multiple Sclerosis by Singhal, Naveen Kumar, Li, Shuo, Arning, Erland, Alkhayer, Kholoud, Clements, Robert, Sarcyk, Zachary, Dassanayake, Rohan S, Brasch, Nicola E, Freeman, Ernest J, Bottiglieri, Teodoro, McDonough, Jennifer

“…Mitochondrial changes, including decreased expression of electron transport chain subunit genes and impaired energetic, have been reported in multiple…”
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Structural and Spectroscopic Evidence for the Formation of Trinuclear and Tetranuclear Vanadium(III)/Carboxylate Complexes of Acetate and Related Derivatives in Aqueous Solution by Mukherjee, Riya, Dougan, Brenda A, Fry, Fiona H, Bunge, Scott D, Ziegler, Christopher J, Brasch, Nicola E

“…The formation of vanadium(III) complexes with nuclearity greater than two is believed to occur in aqueous solution on the basis of potentiometric,…”
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Mechanistic Insights into Rapid Generation of Nitroxyl from a Photocaged N‑Hydroxysulfonamide Incorporating the (6-Hydroxynaphthalen-2-yl)methyl Chromophore by Cink, Ruth B, Zhou, Yang, Du, Lili, Rahman, Mohammad S, Phillips, David Lee, Simpson, M. Cather, Seed, Alexander J, Sampson, Paul, Brasch, Nicola E

“…HNO is a highly reactive molecule that shows promise in treating heart failure. Molecules that rapidly release HNO with precise spatial and temporal control…”
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Stoichiometric Nitroxyl Photorelease Using the (6-Hydroxy-2-naphthalenyl)methyl Phototrigger by Zhou, Yang, Cink, Ruth B, Seed, Alexander J, Simpson, M. Cather, Sampson, Paul, Brasch, Nicola E

“…The design and synthesis of a photoactivatable HNO donor incorporating the (6-hydroxynaphthalen-2-yl)­methyl (6,2-HNM) photocage coupled to the…”
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Synthesis and photochemical studies of 2-nitrobenzyl-caged N-hydroxysulfonamides by Zhou, Yang, Bharadwaj, Vinay, Rahman, Mohammad S., Sampson, Paul, Brasch, Nicola E., Seed, Alexander J.

“…•NO2 group plays a key role in the photoactivity of o-NB caged N-hydroxysulfonamides.•Solvent, pH and the presence of oxygen have little impact on the…”
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Characterization of Novel Vanadium(III)/Acetate Clusters Formed in Aqueous Solution by Fry, Fiona H, Dougan, Brenda A, McCann, Nichola, Ziegler, Christopher J, Brasch, Nicola E

“…We report the first structures of simple acetate complexes of vanadium(III) formed in aqueous solution. Paramagnetic 1H NMR spectroscopy titration experiments…”
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Mechanistic Studies on the Reaction between Cob(II)alamin and Peroxynitrite: Evidence for a Dual Role for Cob(II)alamin as a Scavenger of Peroxynitrous Acid and Nitrogen Dioxide by Mukherjee, Riya, Brasch, Nicola E.

“…Peroxynitrite/peroxynitrous acid (ONOO−/ONOOH; pKa(ONOOH)=6.8) is implicated in multiple chronic inflammatory and neurodegenerative diseases. Both mammalian…”
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Synthesis and HNO Donating Properties of the Piloty's Acid Analogue Trifluoromethanesulphonylhydroxamic Acid: Evidence for Quantitative Release of HNO at Neutral pH Conditions by Adas, Sonya K., Bharadwaj, Vinay, Zhou, Yang, Zhang, Jiuhong, Seed, Alexander J., Brasch, Nicola E., Sampson, Paul

“…Trifluoromethanesulphonylhydroxamic acid, CF3SO2NHOH, is shown to release HNO under physiological pH conditions. A two‐step synthesis is presented with the…”
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