Search Results - "Brasca, Maria G."

The Synthesis of Azadirachtin: A Potent Insect Antifeedant by Ley, Steven V., Abad-Somovilla, Antonio, Anderson, James C., Ayats, Carles, Bänteli, Rolf, Beckmann, Edith, Boyer, Alistair, Brasca, Maria G., Brice, Abigail, Broughton, Howard B., Burke, Brenda J., Cleator, Ed, Craig, Donald, Denholm, Alastair A., Denton, Ross M., Durand-Reville, Thomas, Gobbi, Luca B., Göbel, Michael, Gray, Brian Lawrence, Grossmann, Robert B., Gutteridge, Claire E., Hahn, Norbert, Harding, Sarah L., Jennens, David C., Jennens, Lynn, Lovell, Peter J., Lovell, Helen J., de la Puente, Mary L., Kolb, Hartmuth C., Koot, Win-Jan, Maslen, Sarah L., McCusker, Catherine F., Mattes, Amos, Pape, Andrew R., Pinto, Andrea, Santafianos, Dinos, Scott, James S., Smith, Stephen C., Somers, Andrew Q., Spilling, Christopher D., Stelzer, Frank, Toogood, Peter L., Turner, Richard M., Veitch, Gemma E., Wood, Anthony, Zumbrunn, Cornelia

“…We describe in full the first synthesis of the potent insect antifeedant azadirachtin through a highly convergent approach. An O‐alkylation reaction is used to…”
Get full text

Down-regulation of the PTTG1 proto-oncogene contributes to the melanoma suppressive effects of the cyclin-dependent kinase inhibitor PHA-848125 by Caporali, Simona, Alvino, Ester, Levati, Lauretta, Esposito, Alessia I., Ciomei, Marina, Brasca, Maria G., Del Bufalo, Donatella, Desideri, Marianna, Bonmassar, Enzo, Pfeffer, Ulrich, D’Atri, Stefania

“…We previously demonstrated that PHA-848125, a cyclin-dependent kinase inhibitor presently under Phase II clinical investigation, impairs melanoma cell growth…”
Get full text

NMS-E973, a Novel Synthetic Inhibitor of Hsp90 with Activity against Multiple Models of Drug Resistance to Targeted Agents, Including Intracranial Metastases by FOGLIATTO, Gianpaolo, GIANELLINI, Laura, PAOLUCCI, Mauro, POLUCCI, Paolo, RUSSO, Micaela, SOLA, Francesco, VALSASINA, Barbara, VISCO, Carlo, ZUCCOTTO, Fabio, DONATI, Daniele, FELDER, Eduard, PESENTI, Enrico, BRASCA, Maria G, GALVANI, Arturo, MANTEGANI, Sergio, ISACCHI, Antonella, CASALE, Elena, BALLINARI, Dario, CIOMEI, Marina, DEGRASSI, Anna, DE PONTI, Anna, GERMANI, Massimiliano, GUANCI, Marco

“…Recent developments of second generation Hsp90 inhibitors suggested a potential for development of this class of molecules also in tumors that have become…”
Get full text

Transcriptional analysis of an E2F gene signature as a biomarker of activity of the cyclin-dependent kinase inhibitor PHA-793887 in tumor and skin biopsies from a phase I clinical study by Locatelli, Giuseppe, Bosotti, Roberta, Ciomei, Marina, Brasca, Maria G, Calogero, Raffaele, Mercurio, Ciro, Fiorentini, Francesco, Bertolotti, Matteo, Scacheri, Emanuela, Scaburri, Angela, Galvani, Arturo, Pesenti, Enrico, De Baere, Thierry, Soria, Jean-Charles, Lazar, Vladimir, Isacchi, Antonella

“…A transcriptional signature of the pan-cyclin-dependent kinase (Cdk) inhibitor PHA-793887 was evaluated as a potential pharmacodynamic and/or response…”
Get full text

Cover Picture: The Synthesis of Azadirachtin: A Potent Insect Antifeedant (Chem. Eur. J. 34/2008) by Ley, Steven V., Abad-Somovilla, Antonio, Anderson, James C., Ayats, Carles, Bänteli, Rolf, Beckmann, Edith, Boyer, Alistair, Brasca, Maria G., Brice, Abigail, Broughton, Howard B., Burke, Brenda J., Cleator, Ed, Craig, Donald, Denholm, Alastair A., Denton, Ross M., Durand-Reville, Thomas, Gobbi, Luca B., Göbel, Michael, Gray, Brian Lawrence, Grossmann, Robert B., Gutteridge, Claire E., Hahn, Norbert, Harding, Sarah L., Jennens, David C., Jennens, Lynn, Lovell, Peter J., Lovell, Helen J., de la Puente, Mary L., Kolb, Hartmuth C., Koot, Win-Jan, Maslen, Sarah L., McCusker, Catherine F., Mattes, Amos, Pape, Andrew R., Pinto, Andrea, Santafianos, Dinos, Scott, James S., Smith, Stephen C., Somers, Andrew Q., Spilling, Christopher D., Stelzer, Frank, Toogood, Peter L., Turner, Richard M., Veitch, Gemma E., Wood, Anthony, Zumbrunn, Cornelia

“…An exceptionally challenging synthesis target has finally met its match. An avenue of neem trees flanks an outline of the Ley azadirachtin synthesis road map…”
Get full text