Search Results - "Branton, P E"

SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins by Binda, O, Nassif, C, Branton, P E

“…Both RBP1 and the highly related protein BCAA play a role in the induction of growth arrest and cellular senescence via mechanisms involving transcriptional…”
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Regulation of apoptosis by viral gene products by Teodoro, J G, Branton, P E

“…Apoptosis is the process whereby individual cells of multicellular organisms undergo systematic self-destruction in response to a wide variety of stimuli…”
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The adenovirus E4orf4 protein induces growth arrest and mitotic catastrophe in H1299 human lung carcinoma cells by Li, S, Szymborski, A, Miron, M-J, Marcellus, R, Binda, O, Lavoie, J N, Branton, P E

“…The human adenovirus E4orf4 protein, when expressed alone, induces p53-independent death in a wide range of cancer cells. Earlier studies by our groups…”
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VIRUSES AND APOPTOSIS by Roulston, Anne, Marcellus, Richard C, Branton, Philip E

“…Successful viral replication requires not only the efficient production and spread of progeny, but also evasion of host defense mechanisms that limit…”
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RBP1 Recruits the mSIN3-Histone Deacetylase Complex to the Pocket of Retinoblastoma Tumor Suppressor Family Proteins Found in Limited Discrete Regions of the Nucleus at Growth Arrest by Lai, Albert, Kennedy, Brian K., Barbie, David A., Bertos, Nicholas R., Yang, Xiang Jiao, Theberge, Marie-Christine, Tsai, Shih-Chang, Seto, Edward, Zhang, Yi, Kuzmichev, Andrei, Lane, William S., Reinberg, Danny, Harlow, Ed, Branton, Philip E.

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E4orf4, a Novel Adenovirus Death Factor That Induces p53-Independent Apoptosis by a Pathway That Is Not Inhibited by zVAD-fmk by Lavoie, Josée N., Nguyen, M., Marcellus, R. C., Branton, P. E., Shore, G. C.

“…In the absence of E1B, the 289-amino acid product of human adenovirus type 5 13S E1A induces p53-independent apoptosis by a mechanism that requires viral E4…”
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PML isoforms IV and V contribute to adenovirus-mediated oncogenic transformation by functionally inhibiting the tumor-suppressor p53 by Wimmer, P, Berscheminski, J, Blanchette, P, Groitl, P, Branton, P E, Hay, R T, Dobner, T, Schreiner, S

“…Although modulation of the cellular tumor-suppressor p53 is considered to have the major role in E1A/E1B-55K-mediated tumorigenesis, other promyelocytic…”
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Induction of p53-Independent Apoptosis by the Adenovirus E4orf4 Protein Requires Binding to the Bα Subunit of Protein Phosphatase 2A by Marcellus, Richard C., Chan, Helen, Paquette, Denis, Thirlwell, Sarah, Boivin, Dominique, Branton, Philip E.

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Identification of Three Functions of the Adenovirus E4orf6 Protein That Mediate p53 Degradation by the E4orf6-E1B55K Complex by Querido, E, Morrison, M R, Chu-Pham-Dang, H, Thirlwell, S W, Boivin, D, Branton, P E, Morisson, M R

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Cross-talk between phosphorylation and SUMOylation regulates transforming activities of an adenoviral oncoprotein by Wimmer, P, Blanchette, P, Schreiner, S, Ching, W, Groitl, P, Berscheminski, J, Branton, P E, Will, H, Dobner, T

“…Since the discovery of post-translational modification (PTM) by the small ubiquitin-related modifiers (SUMOs), a multitude of proteins have been described to…”
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Role of membrane anchor domain of Bcl-2 in suppression of apoptosis caused by E1B-defective adenovirus by MAI NGUYEN, BRANTON, P. E, WALTON, P. A, OLTVAI, Z. N, KORSMEYER, S. J, SHORE, G. C

“…Bcl-2 is an integral membrane protein that functions as a suppressor of programmed cell death. It contains a COOH-terminal signal anchor sequence that is…”
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Regulation of p53-dependent apoptosis, transcriptional repression, and cell transformation by phosphorylation of the 55-kilodalton E1B protein of human adenovirus type 5 by Teodoro, J G, Branton, P E

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Mapping of cellular protein-binding sites on the products of early-region 1A of human adenovirus type 5 by EGAN, C, JELSMA, T. N, HOWE, J. A, BAYLEY, S. T, FERGUSON, B, BRANTON, P. E

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Accumulation of p53 induced by the adenovirus E1A protein requires regions involved in the stimulation of DNA synthesis by Querido, E, Teodoro, J G, Branton, P E

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RBP1 induces growth arrest by repression of E2F-dependent transcription by LAI, A, MARCELLUS, R. C, CORBEIL, H. B, BRANTON, P. E

“…Growth arrest and cell cycle progression are regulated by the retinoblastoma tumour suppressor pRB and related proteins p130 and p107 that bind to and inhibit…”
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Functional interactions within adenovirus E1A protein complexes by Barbeau, D, Charbonneau, R, Whalen, S G, Bayley, S T, Branton, P E

“…The transforming potential of adenovirus E1A oncogene products derives largely from the formation of complexes with cellular proteins, including the p105Rb…”
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Adenovirus type 5 early region 4 is responsible for E1A-induced p53-independent apoptosis by Marcellus, R C, Teodoro, J G, Wu, T, Brough, D E, Ketner, G, Shore, G C, Branton, P E

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Degradation of p53 by adenovirus E4orf6 and E1B55K proteins occurs via a novel mechanism involving a Cullin-containing complex by Querido, E, Blanchette, P, Yan, Q, Kamura, T, Morrison, M, Boivin, D, Kaelin, W G, Conaway, R C, Conaway, J W, Branton, P E

“…Although MDM2 plays a major role in regulating the stability of the p53 tumor suppressor protein, other poorly understood MDM2-independent pathways also exist…”
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Phosphorylation at the carboxy terminus of the 55-kilodalton adenovirus type 5 E1B protein regulates transforming activity by TEODORO, J. G, HALLIDAY, T, WHALEN, S. G, TAKAYESU, D, GRAHAM, F. L, BRANTON, P. E

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Retinoblastoma Growth Suppressor and a 300-kDa Protein Appear to Regulate Cellular DNA Synthesis by Howe, John A., Mymryk, Joe S., Egan, Cay, Branton, Philip E., Bayley, Stanley T.

“…Previous work has suggested that oncogenic transformation by the E1A gene products of adenovirus type 5 may be mediated through interactions with at least two…”
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