Elevated Transaminases as Predictors of COVID-19 Pneumonia Severity

Background: This study aimed to calculate the frequency of elevated liver enzymes in hospitalized patients with coronavirus disease 2019 (COVID-19) infection and to test if liver enzyme biochemistry levels on admission could predict the computed tomography (CT) scan severity score of bilateral inter...

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Published in:	Medicina (Kaunas, Lithuania) Vol. 58; no. 7; p. 842
Main Authors:	Radonjić, Tijana, Milićević, Ognjen, Jovanović, Igor, Zdravković, Marija, Dukić, Marija, Mandić, Olga Milorad, Bjekić-Macut, Jelica, Marković, Olivera Borko, Todorović, Zoran, Brajković, Milica, Nikolić, Novica, Klašnja, Slobodan, Popadić, Višeslav, Divac, Anica, Marinković, Milica, Alhayek, Nabil, Branković, Marija Svetislav
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 23-06-2022 MDPI
Subjects:	Blood tests Coronaviruses COVID-19 Diagnostic tests Enzymes Hepatitis Hospitals Infections Intensive care Laboratories Length of stay liver Liver diseases Lungs Medical imaging Pandemics Patients Pneumonia SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 Thorax transaminases Ventilators Serbia
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Summary:	Background: This study aimed to calculate the frequency of elevated liver enzymes in hospitalized patients with coronavirus disease 2019 (COVID-19) infection and to test if liver enzyme biochemistry levels on admission could predict the computed tomography (CT) scan severity score of bilateral interstitial pneumonia. Methods: This single-center study comprised of 323 patients including their demographic data, laboratory analyses, and radiological findings. All the information was taken from electronic health records, followed by statistical analysis. Results: Out of 323 patients, 115 of them (35.60%) had aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) over 40 U/L on admission. AST was the best predictor of CT scan severity score of bilateral interstitial pneumonia (R2 = 0.313, Adjusted R2 = 0.299). CT scan severity score in the peak of the infection could be predicted with the value of AST, neutrophils, platelets, and monocytes count (R2 = 0.535, Adjusted R2 = 0.495). Conclusion: AST, neutrophils, platelets, and monocytes count on admission can account for almost half (49.5%) of the variability in CT scan severity score at peak of the disease, predicting the extensiveness of interstitial pneumonia related to COVID-19 infection. Liver enzymes should be closely monitored in order to stratify COVID-19 patients with a higher risk of developing severe forms of the disease and to plan the beforehand step-up treatment.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1648-9144 1010-660X 1648-9144
DOI:	10.3390/medicina58070842