Search Results - "Brancolini, Claudio"

Targeting histone deacetylases for combination therapies in neuroendocrine tumors by Gagliano, Teresa, Brancolini, Claudio

Get full text

MEF2 and the tumorigenic process, hic sunt leones by Di Giorgio, Eros, Hancock, Wayne W., Brancolini, Claudio

“…While MEF2 transcription factors are well known to cooperate in orchestrating cell fate and adaptive responses during development and adult life, additional…”
Get full text

HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers by Di Giorgio, Eros, Paluvai, Harikrishnareddy, Dalla, Emiliano, Ranzino, Liliana, Renzini, Alessandra, Moresi, Viviana, Minisini, Martina, Picco, Raffaella, Brancolini, Claudio

“…Cellular senescence is a permanent state of replicative arrest defined by a specific pattern of gene expression. The epigenome in senescent cells is sculptured…”
Get full text

The Histone Code of Senescence by Paluvai, Harikrishnareddy, Di Giorgio, Eros, Brancolini, Claudio

“…Senescence is the end point of a complex cellular response that proceeds through a set of highly regulated steps. Initially, the permanent cell-cycle arrest…”
Get full text

Acetylation and Phosphorylation in the Regulation of Hypoxia-Inducible Factor Activities: Additional Options to Modulate Adaptations to Changes in Oxygen Levels by Minisini, Martina, Cricchi, Emanuele, Brancolini, Claudio

“…O is essential for the life of eukaryotic cells. The ability to sense oxygen availability and initiate a response to adapt the cell to changes in O levels is a…”
Get full text

Unscheduled HDAC4 repressive activity in human fibroblasts triggers TP53‐dependent senescence and favors cell transformation by Paluvai, Harikrishnareddy, Di Giorgio, Eros, Brancolini, Claudio

“…Expression of the class IIa HDACs is frequently altered in different human cancers. In mouse models these transcriptional repressors can trigger…”
Get full text

HDAC7‐mediated control of tumour microenvironment maintains proliferative and stemness competence of human mammary epithelial cells by Cutano, Valentina, Di Giorgio, Eros, Minisini, Martina, Picco, Raffaella, Dalla, Emiliano, Brancolini, Claudio

“…HDAC7 is a pleiotropic transcriptional coregulator that controls different cellular fates. Here, we demonstrate that in human mammary epithelial cells, HDAC7…”
Get full text

GSK3β is a key regulator of the ROS-dependent necrotic death induced by the quinone DMNQ by Ciotti, Sonia, Iuliano, Luca, Cefalù, Sebastiano, Comelli, Marina, Mavelli, Irene, Di Giorgio, Eros, Brancolini, Claudio

“…Signaling pathways controlling necrosis are still mysterious and debated. We applied a shRNA-based viability screen to identify critical elements of the…”
Get full text

Transcription of endogenous retroviruses in senescent cells contributes to the accumulation of double-stranded RNAs that trigger an anti-viral response that reinforces senescence by Di Giorgio, Eros, Ranzino, Liliana, Tolotto, Vanessa, Dalla, Emiliano, Burelli, Matteo, Gualandi, Nicolò, Brancolini, Claudio

“…An important epigenetic switch marks the onset and maintenance of senescence. This allows transcription of the genetic programs that arrest the cell cycle and…”
Get full text

HDAC4 in cancer: A multitasking platform to drive not only epigenetic modifications by Cuttini, Emma, Goi, Camilla, Pellarin, Ester, Vida, Riccardo, Brancolini, Claudio

“…Controlling access to genomic information and maintaining its stability are key aspects of cell life. Histone acetylation is a reversible epigenetic…”
Get full text

The co-existence of transcriptional activator and transcriptional repressor MEF2 complexes influences tumor aggressiveness by Di Giorgio, Eros, Franforte, Elisa, Cefalù, Sebastiano, Rossi, Sabrina, Dei Tos, Angelo Paolo, Brenca, Monica, Polano, Maurizio, Maestro, Roberta, Paluvai, Harikrishnareddy, Picco, Raffaella, Brancolini, Claudio

“…The contribution of MEF2 TFs to the tumorigenic process is still mysterious. Here we clarify that MEF2 can support both pro-oncogenic or tumor suppressive…”
Get full text

Changes in chromatin accessibility and transcriptional landscape induced by HDAC inhibitors in TP53 mutated patient-derived colon cancer organoids by Gagliano, Teresa, Kerschbamer, Emanuela, Baccarani, Umberto, Minisini, Martina, Di Giorgio, Eros, Dalla, Emiliano, Weichenberger, Christian X., Cherchi, Vittorio, Terrosu, Giovanni, Brancolini, Claudio

“…Here we present the generation and characterization of patient-derived organoids (PDOs) from colorectal cancer patients. PDOs derived from two patients with…”
Get full text

Quis Custodiet Ipsos Custodes (Who Controls the Controllers)? Two Decades of Studies on HDAC9 by Brancolini, Claudio, Di Giorgio, Eros, Formisano, Luigi, Gagliano, Teresa

“…Understanding how an epigenetic regulator drives different cellular responses can be a tricky task. Very often, their activities are modulated by large…”
Get full text

The MEF2-HDAC axis controls proliferation of mammary epithelial cells and acini formation in vitro by Clocchiatti, Andrea, Di Giorgio, Eros, Viviani, Giulia, Streuli, Charles, Sgorbissa, Andrea, Picco, Raffaella, Cutano, Valentina, Brancolini, Claudio

“…The myocyte enhancer factor 2 and histone deacetylase (MEF2-HDAC) axis is a master regulator of different developmental programs and adaptive responses in…”
Get full text

Transcriptomic analysis unveils correlations between regulative apoptotic caspases and genes of cholesterol homeostasis in human brain by Picco, Raffaella, Tomasella, Andrea, Fogolari, Federico, Brancolini, Claudio

“…Regulative circuits controlling expression of genes involved in the same biological processes are frequently interconnected. These circuits operate to…”
Get full text

Proteotoxic stress-induced apoptosis in cancer cells: understanding the susceptibility and enhancing the potency by Iuliano, Luca, Dalla, Emiliano, Picco, Raffaella, Mallavarapu, Showmeya, Minisini, Martina, Malavasi, Eleonora, Brancolini, Claudio

“…Leiomyosarcoma (LMS) is aggressive cancer with few therapeutic options. LMS cells are more sensitive to proteotoxic stress compared to normal smooth muscle…”
Get full text

Potent and Selective Non-hydroxamate Histone Deacetylase 8 Inhibitors by Kleinschek, Alexander, Meyners, Christian, Digiorgio, Eros, Brancolini, Claudio, Meyer-Almes, Franz-Josef

“…Specific inhibition of histone deacetylase 8 (HDAC8) has been suggested as a promising option for the treatment of neuroblastoma and T‐cell malignancies. A…”
Get full text

Calpain is required for macroautophagy in mammalian cells by Demarchi, Francesca, Bertoli, Cosetta, Copetti, Tamara, Tanida, Isei, Brancolini, Claudio, Eskelinen, Eeva-Liisa, Schneider, Claudio

“…Ubiquitously expressed micro- and millicalpain, which both require the calpain small 1 (CAPNS1) regulatory subunit for function, play important roles in…”
Get full text

A Biological Circuit Involving Mef2c, Mef2d, and Hdac9 Controls the Immunosuppressive Functions of CD4+Foxp3+ T-Regulatory Cells by Di Giorgio, Eros, Wang, Liqing, Xiong, Yan, Christensen, Lanette M, Akimova, Tatiana, Han, Rongxiang, Samanta, Arabinda, Trevisanut, Matteo, Brancolini, Claudio, Beier, Ulf H, Hancock, Wayne W

“…The Mads/Mef2 (Mef2a/b/c/d) family of transcription factors (TFs) regulates differentiation of muscle cells, neurons and hematopoietic cells. By functioning in…”
Get full text

MEF2 Is a Converging Hub for Histone Deacetylase 4 and Phosphatidylinositol 3-Kinase/Akt-Induced Transformation by Di Giorgio, Eros, Clocchiatti, Andrea, Piccinin, Sara, Sgorbissa, Andrea, Viviani, Giulia, Peruzzo, Paolo, Romeo, Salvatore, Rossi, Sabrina, Dei Tos, Angelo Paolo, Maestro, Roberta, Brancolini, Claudio

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text