Using the Juvenile Arthritis Disease Activity Score Based on Erythrocyte Sedimentation Rate or C‐Reactive Protein Level: Results From the Portuguese Register

Using the Juvenile Arthritis Disease Activity Score Based on Erythrocyte Sedimentation Rate or C‐Reactive Protein Level: Results From the Portuguese Register

Objective Our aims were to evaluate the correlation between Juvenile Arthritis Disease Activity Score 27‐joint reduced count (JADAS27) with erythrocyte sedimentation rate (ESR) and JADAS27 with C‐reactive protein (CRP) scores and to test the agreement of both scores on classifying each disease activ...

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Bibliographic Details
Published in:Arthritis care & research (2010) Vol. 66; no. 4; pp. 585 - 591
Main Authors: Mourão, Ana F., Santos, Maria J., Melo‐Gomes, José, Martins, Fernando M., Costa, José A., Ramos, Filipa, Brito, Iva, Duarte, Cátia, Figueira, Ricardo, Figueiredo, Guilherme, Furtado, Carolina, Lopes, Ana, Oliveira, Margarida, Rodrigues, Ana, Salgado, Manuel, Sousa, Miguel, Branco, Jamie C., Fonseca, João E., Canhão, Helena
Format: Journal Article
Language:English
Published: United States 01-04-2014
Subjects:
Adolescent
Arthritis, Juvenile - blood
Arthritis, Juvenile - diagnosis
Arthritis, Juvenile - pathology
Biomarkers - blood
Blood Sedimentation
C-Reactive Protein - analysis
Child
Female
Humans
Inflammation Mediators - blood
Joints - pathology
Linear Models
Male
Portugal
Predictive Value of Tests
Prognosis
Registries
Reproducibility of Results
Severity of Illness Index
Portugal
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Summary:Objective Our aims were to evaluate the correlation between Juvenile Arthritis Disease Activity Score 27‐joint reduced count (JADAS27) with erythrocyte sedimentation rate (ESR) and JADAS27 with C‐reactive protein (CRP) scores and to test the agreement of both scores on classifying each disease activity state. We also aimed at verifying the correlation of the 2 scores across juvenile idiopathic arthritis (JIA) categories and to check the correlation between JADAS27‐ESR and clinical JADAS27 (JADAS27 without ESR). Methods A nationwide cohort of patients with JIA registered in the Portuguese Register, Reuma.pt, was studied. JADAS27‐CRP was adapted by replacing ESR with CRP level as the inflammatory marker. JADAS27‐CRP was calculated similarly to JADAS27‐ESR as the simple linear sum of its 4 components. Pearson's correlations and K statistics were used in the analyses. Results A total of 358 children had full data to calculate JADAS27; 65.4% were female and the mean ± SD disease duration was 11.8 ± 9.1 years. The correlation coefficient between JADAS27‐ESR and JADAS27‐CRP was 0.967 (P < 0.0001), although the correlation coefficient between ESR and CRP level was 0.335 (P < 0.0001). The strong correlation between JADAS27‐ESR and JADAS27‐CRP was maintained when compared within each JIA category. The agreement between JADAS27‐ESR and JADAS27‐CRP across the 4 activity states was very good, showing 91.1% of the observations in agreement; K = 0.867 (95% confidence interval 0.824–0.91). The correlation between JADAS27 with ESR and JADAS27 without ESR was high (r = 0.97, P < 0.0001). Conclusion JADAS27 based on CRP level correlated closely with JADAS27‐ESR across all disease activity states and JIA categories, indicating that both measures can be used in clinical practice. Moreover, the correlation of JADAS27 with and without ESR was also high, suggesting that this tool might be useful even in the absence of laboratorial measures.
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ISSN:2151-464X
2151-4658
DOI:10.1002/acr.22215