Search Results - "Branchi, Igor"

The double edged sword of neural plasticity: Increasing serotonin levels leads to both greater vulnerability to depression and improved capacity to recover by Branchi, Igor

“…Summary Major depression is a chronic, recurring and potentially life-threatening illness that affects up to 10% of the population worldwide. Pharmacological…”
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Psychedelics and the essential importance of context by Carhart-Harris, Robin L, Roseman, Leor, Haijen, Eline, Erritzoe, David, Watts, Rosalind, Branchi, Igor, Kaelen, Mendel

“…Psychedelic drugs are making waves as modern trials support their therapeutic potential and various media continue to pique public interest. In this opinion…”
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Fractalkine receptor deficiency impairs microglial and neuronal responsiveness to chronic stress by Milior, Giampaolo, Lecours, Cynthia, Samson, Louis, Bisht, Kanchan, Poggini, Silvia, Pagani, Francesca, Deflorio, Cristina, Lauro, Clotilde, Alboni, Silvia, Limatola, Cristina, Branchi, Igor, Tremblay, Marie-Eve, Maggi, Laura

“…Highlights • Chronic unpredictable stress reduces microglial arborization area and increases phagocytosis of synaptic elements. • Chronic unpredictable stress…”
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Predicting antidepressant treatment outcome based on socioeconomic status and citalopram dose by Viglione, Aurelia, Chiarotti, Flavia, Poggini, Silvia, Giuliani, Alessandro, Branchi, Igor

“…Selective serotonin reuptake inhibitors (SSRIs), the most prescribed antidepressant drugs, have incomplete efficacy and no clear mechanism of action. In…”
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Antidepressant treatment outcome depends on the quality of the living environment: a pre-clinical investigation in mice by Branchi, Igor, Santarelli, Sara, Capoccia, Sara, Poggini, Silvia, D'Andrea, Ivana, Cirulli, Francesca, Alleva, Enrico

“…Antidepressants represent the standard treatment for major depression. However, their efficacy is variable and incomplete. A growing number of studies suggest…”
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Time moderates the interplay between 5-HTTLPR and stress on depression risk: gene x environment interaction as a dynamic process by Delli Colli, Claudia, Borgi, Marta, Poggini, Silvia, Chiarotti, Flavia, Cirulli, Francesca, Penninx, Brenda W. J. H., Benedetti, Francesco, Vai, Benedetta, Branchi, Igor

“…The serotonin-transporter-linked promoter region (5-HTTLPR) has been widely investigated as contributing to depression vulnerability. Nevertheless, empirical…”
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Early Social Enrichment Shapes Social Behavior and Nerve Growth Factor and Brain-Derived Neurotrophic Factor Levels in the Adult Mouse Brain by Branchi, Igor, D’Andrea, Ivana, Fiore, Marco, Di Fausto, Veronica, Aloe, Luigi, Alleva, Enrico

“…Early experiences produce persistent changes in brain and behavioral function. We investigate whether being reared in a communal nest (CN), a form of early…”
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Combined Fluoxetine and Metformin Treatment Potentiates Antidepressant Efficacy Increasing IGF2 Expression in the Dorsal Hippocampus by Limatola, Cristina, Maggi, Laura, Branchi, Igor, Brunello, Nicoletta, Matte Bon, Gloria, Viglione, Aurelia, Sciarria, Livio Pepè, Milior, Giampaolo, Alboni, Silvia, Golia, Maria Teresa, Poggini, Silvia, Puglisi-Allegra, Stefano

“…An increasing number of studies show that selective serotonin reuptake inhibitors (SSRIs) exert their therapeutic action, at least in part, by amplifying the…”
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The role of microglia in mediating the effect of the environment in brain plasticity and behavior by Branchi, Igor, Alboni, Silvia, Maggi, Laura

“…[...]these cells respond to sensory and behavioral experience (e.g., deprivation of visual stimuli, environmental enrichment) by modulating their interactions…”
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Recentering neuroscience on behavior: The interface between brain and environment is a privileged level of control of neural activity by Branchi, Igor

“…Despite the huge and constant progress in the molecular and cellular neuroscience fields, our capability to understand brain alterations and treat mental…”
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Uncovering the determinants of brain functioning, behavior and their interplay in the light of context by Branchi, Igor

“…Notwithstanding the huge progress in molecular and cellular neuroscience, our ability to understand the brain and develop effective treatments promoting mental…”
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Taming Complexity from the Interface: Simplifying Neuroscience by Branchi, Igor

“…•Interfaces have evolved to ensure effective interaction with the environment.•Effective interaction results in remarkable simplicity.•Interfaces are a unique…”
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Nonmotor symptoms in Parkinson's disease: Investigating early-phase onset of behavioral dysfunction in the 6-hydroxydopamine-lesioned rat model by Branchi, Igor, D'Andrea, Ivana, Armida, Monica, Cassano, Tommaso, Pèzzola, Antonella, Potenza, Rosa Luisa, Morgese, Maria Grazia, Popoli, Patrizia, Alleva, Enrico

“…To investigate the psychiatric symptoms accompanying the early phases of Parkinson's disease (PD), we injected adult rats with 10.5 μg 6‐hydroxydopamine…”
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Plasticity in mental health: A network theory by Branchi, Igor

“…Plasticity is the ability to modify brain and behavior, ultimately promoting an amplification of the impact of the context on the individual’s mental health…”
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A mathematical formula of plasticity: Measuring susceptibility to change in mental health and data science by Branchi, Igor

“…Plasticity is increasingly recognized as a critical concept in psychiatry and mental health because it allows the reorganization of neural circuits and…”
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Polybrominated Diphenyl Ethers: Neurobehavioral Effects Following Developmental Exposure by Branchi, Igor, Capone, Francesca, Alleva, Enrico, Costa, Lucio G.

“…Polybrominated diphenyl ethers (PBDEs), a class of widely used flame retardants, are becoming widespread environmental pollutants, as indicated by studies on…”
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Early social enrichment augments adult hippocampal BDNF levels and survival of BrdU-positive cells while increasing anxiety- and "depression"-like behavior by Branchi, Igor, D'Andrea, Ivana, Sietzema, Jantine, Fiore, Marco, Di Fausto, Veronica, Aloe, Luigi, Alleva, Enrico

“…Early experiences affect brain function and behavior at adulthood. Being reared in a communal nest (CN), consisting of a single nest where three mothers keep…”
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The mouse communal nest: Investigating the epigenetic influences of the early social environment on brain and behavior development by Branchi, Igor

“…Among the epigenetic factors shaping brain and behavior during early postnatal life, social experiences have a major impact. Early social experiences are…”
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Effects of Perinatal Exposure to a Polybrominated Diphenyl Ether (PBDE 99) on Mouse Neurobehavioural Development by Branchi, Igor, Alleva, Enrico, Costa, Lucio G.

“…Polybrominated diphenyl ethers (PBDEs), a class of widely used flame retardants, are extensively diffused in the environment as shown by several studies on…”
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Birth spacing in the mouse communal nest shapes adult emotional and social behavior by Branchi, Igor, D'Andrea, Ivana, Gracci, Fiorenza, Santucci, Daniela, Alleva, Enrico

“…Abstract The interactions with the mother and with peers are among the most relevant early environmental factors shaping adult brain function and behavior. In…”
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