Search Results - "Branch Moody, D"

Efficient and precise single-cell reference atlas mapping with Symphony by Kang, Joyce B., Nathan, Aparna, Weinand, Kathryn, Zhang, Fan, Millard, Nghia, Rumker, Laurie, Moody, D. Branch, Korsunsky, Ilya, Raychaudhuri, Soumya

“…Recent advances in single-cell technologies and integration algorithms make it possible to construct comprehensive reference atlases encompassing many donors,…”
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Lipid and small-molecule display by CD1 and MR1 by Van Rhijn, Ildiko, Godfrey, Dale I., Rossjohn, Jamie, Moody, D. Branch

“…Key Points Whereas peptide–MHC complexes are the usual model for technology development focused on T cells, the discovery of lipids and non-lipid small…”
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CD1a and bound lipids drive T‐cell responses in human skin disease by Ogg, Graham S., Rossjohn, Jamie, Clark, Rachael A., Moody, D. Branch

“…In addition to serving as the main physical barrier with the outside world, human skin is abundantly infiltrated with resident αβ T cells that respond…”
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Protein kinases PknA and PknB independently and coordinately regulate essential Mycobacterium tuberculosis physiologies and antimicrobial susceptibility by Zeng, Jumei, Platig, John, Cheng, Tan-Yun, Ahmed, Saima, Skaf, Yara, Potluri, Lakshmi-Prasad, Schwartz, Daniel, Steen, Hanno, Moody, D Branch, Husson, Robert N

“…The Mycobacterium tuberculosis Ser/Thr protein kinases PknA and PknB are essential for growth and have been proposed as possible drug targets. We used a…”
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Multimodally profiling memory T cells from a tuberculosis cohort identifies cell state associations with demographics, environment and disease by Nathan, Aparna, Beynor, Jessica I., Baglaenko, Yuriy, Suliman, Sara, Ishigaki, Kazuyoshi, Asgari, Samira, Huang, Chuan-Chin, Luo, Yang, Zhang, Zibiao, Lopez, Kattya, Lindestam Arlehamn, Cecilia S., Ernst, Joel D., Jimenez, Judith, Calderón, Roger I., Lecca, Leonid, Van Rhijn, Ildiko, Moody, D. Branch, Murray, Megan B., Raychaudhuri, Soumya

“…Multimodal T cell profiling can enable more precise characterization of elusive cell states underlying disease. Here, we integrated single-cell RNA and surface…”
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Mycobacterium tuberculosis releases an antacid that remodels phagosomes by Buter, Jeffrey, Cheng, Tan-Yun, Ghanem, Marwan, Grootemaat, Anita E., Raman, Sahadevan, Feng, Xinxin, Plantijn, Ashmir R., Ennis, Thomas, Wang, Joyce, Cotton, Rachel N., Layre, Emilie, Ramnarine, Alexandrea K., Mayfield, Jacob A., Young, David C., Jezek Martinot, Amanda, Siddiqi, Noman, Wakabayashi, Shoko, Botella, Helene, Calderon, Roger, Murray, Megan, Ehrt, Sabine, Snider, Barry B., Reed, Michael B., Oldfield, Eric, Tan, Shumin, Rubin, Eric J., Behr, Marcel A., van der Wel, Nicole N., Minnaard, Adriaan J., Moody, D. Branch

“…Mycobacterium tuberculosis ( Mtb ) is the world’s most deadly pathogen. Unlike less virulent mycobacteria, Mtb produces 1-tuberculosinyladenosine (1-TbAd), an…”
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The Mycobacterium tuberculosis regulatory network and hypoxia by Galagan, James E., Minch, Kyle, Peterson, Matthew, Lyubetskaya, Anna, Azizi, Elham, Sweet, Linsday, Gomes, Antonio, Rustad, Tige, Dolganov, Gregory, Glotova, Irina, Abeel, Thomas, Mahwinney, Chris, Kennedy, Adam D., Allard, René, Brabant, William, Krueger, Andrew, Jaini, Suma, Honda, Brent, Yu, Wen-Han, Hickey, Mark J., Zucker, Jeremy, Garay, Christopher, Weiner, Brian, Sisk, Peter, Stolte, Christian, Winkler, Jessica K., Van de Peer, Yves, Iazzetti, Paul, Camacho, Diogo, Dreyfuss, Jonathan, Liu, Yang, Dorhoi, Anca, Mollenkopf, Hans-Joachim, Drogaris, Paul, Lamontagne, Julie, Zhou, Yiyong, Piquenot, Julie, Park, Sang Tae, Raman, Sahadevan, Kaufmann, Stefan H. E., Mohney, Robert P., Chelsky, Daniel, Moody, D. Branch, Sherman, David R., Schoolnik, Gary K.

“…We have taken the first steps towards a complete reconstruction of the Mycobacterium tuberculosis regulatory network based on ChIP-Seq and combined this…”
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A Macrophage Response to Mycobacterium leprae Phenolic Glycolipid Initiates Nerve Damage in Leprosy by Madigan, Cressida A., Cambier, C.J., Kelly-Scumpia, Kindra M., Scumpia, Philip O., Cheng, Tan-Yun, Zailaa, Joseph, Bloom, Barry R., Moody, D. Branch, Smale, Stephen T., Sagasti, Alvaro, Modlin, Robert L., Ramakrishnan, Lalita

“…Mycobacterium leprae causes leprosy and is unique among mycobacterial diseases in producing peripheral neuropathy. This debilitating morbidity is attributed to…”
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Co-varying neighborhood analysis identifies cell populations associated with phenotypes of interest from single-cell transcriptomics by Reshef, Yakir A., Rumker, Laurie, Kang, Joyce B., Nathan, Aparna, Korsunsky, Ilya, Asgari, Samira, Murray, Megan B., Moody, D. Branch, Raychaudhuri, Soumya

“…As single-cell datasets grow in sample size, there is a critical need to characterize cell states that vary across samples and associate with sample…”
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Early progression to active tuberculosis is a highly heritable trait driven by 3q23 in Peruvians by Luo, Yang, Suliman, Sara, Asgari, Samira, Amariuta, Tiffany, Baglaenko, Yuriy, Martínez-Bonet, Marta, Ishigaki, Kazuyoshi, Gutierrez-Arcelus, Maria, Calderon, Roger, Lecca, Leonid, León, Segundo R., Jimenez, Judith, Yataco, Rosa, Contreras, Carmen, Galea, Jerome T., Becerra, Mercedes, Nejentsev, Sergey, Nigrovic, Peter A., Moody, D. Branch, Murray, Megan B., Raychaudhuri, Soumya

“…Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis , 5–15% will develop active tuberculosis (TB). Approximately half will progress to…”
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Mincle is a long sought receptor for mycobacterial cord factor by Matsunaga, Isamu, Moody, D Branch

“…Mycobacterium tuberculosis is a leading killer worldwide, yet the adjuvancy of its cell wall has proven to be a valuable therapeutic tool for vaccination and…”
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A periplasmic cinched protein is required for siderophore secretion and virulence of Mycobacterium tuberculosis by Zhang, Lei, Kent, James E., Whitaker, Meredith, Young, David C., Herrmann, Dominik, Aleshin, Alexander E., Ko, Ying-Hui, Cingolani, Gino, Saad, Jamil S., Moody, D. Branch, Marassi, Francesca M., Ehrt, Sabine, Niederweis, Michael

“…Iron is essential for growth of Mycobacterium tuberculosis , the causative agent of tuberculosis. To acquire iron from the host, M. tuberculosis uses the…”
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Hepatitis B virus–induced lipid alterations contribute to natural killer T cell–dependent protective immunity by Zeissig, Sebastian, Murata, Kazumoto, Sweet, Lindsay, Publicover, Jean, Hu, Zongyi, Kaser, Arthur, Bosse, Esther, Iqbal, Jahangir, Hussain, M Mahmood, Balschun, Katharina, Röcken, Christoph, Arlt, Alexander, Günther, Rainer, Hampe, Jochen, Schreiber, Stefan, Baron, Jody L, Moody, D Branch, Liang, T Jake, Blumberg, Richard S

“…Hepatitis B virus (HBV) infection is known to be controlled by T and B cell responses, but the role of natural killer T (NKT) cells is less clear. Richard…”
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Establishment of CD1b-restricted immunity to lipid antigens in the pulmonary response to Mycobacterium tuberculosis infection by Harris, Macallister C., Gary, Hadley E., Cooper, Sarah K., Ackart, David F., DiLisio, James E., Basaraba, Randall J., Cheng, Tan-Yun, van Rhijn, Ildiko, Branch Moody, D., Podell, Brendan K.

“…CD1 is an antigen-presenting glycoprotein homologous to MHC I; however, CD1 proteins present lipid rather than peptide antigens. CD1 proteins are well…”
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COPI acts in both vesicular and tubular transport by Luini, Alberto, Hsu, Victor W, Yang, Jia-Shu, Valente, Carmen, Polishchuk, Roman S, Turacchio, Gabriele, Layre, Emilie, Branch Moody, D, Leslie, Christina C, Gelb, Michael H, Brown, William J, Corda, Daniela

“…Intracellular transport occurs through two general types of carrier, either vesicles or tubules. Coat proteins act as the core machinery that initiates vesicle…”
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Total Synthesis of a Mycolic Acid from Mycobacterium tuberculosis by Tahiri, Nabil, Fodran, Peter, Jayaraman, Dhineshkumar, Buter, Jeffrey, Witte, Martin D., Ocampo, Tonatiuh A., Moody, D. Branch, Van Rhijn, Ildiko, Minnaard, Adriaan J.

“…In Mycobacterium tuberculosis, mycolic acids and their glycerol, glucose, and trehalose esters (“cord factor”) form the main part of the mycomembrane. Despite…”
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Harnessing donor unrestricted T-cells for new vaccines against tuberculosis by Joosten, Simone A., Ottenhoff, Tom H.M., Lewinsohn, David M., Hoft, Daniel F., Moody, D. Branch, Seshadri, Chetan

“…Mycobacterium bovis bacille Calmette-Guérin (BCG) prevents extrapulmonary tuberculosis (TB) and death among infants but fails to consistently and sufficiently…”
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History of tuberculosis disease is associated with genetic regulatory variation in Peruvians by Nieto-Caballero, Victor E, Reijneveld, Josephine F, Ruvalcaba, Angel, Innocenzi, Gabriel, Abeydeera, Nalin, Asgari, Samira, Lopez, Kattya, Iwany, Sarah K, Luo, Yang, Nathan, Aparna, Fernandez-Salinas, Daniela, Chiñas, Marcos, Huang, Chuan-Chin, Zhang, Zibiao, León, Segundo R, Calderon, Roger I, Lecca, Leonid, Budzik, Jonathan M, Murray, Megan, Van Rhijn, Ildiko, Raychaudhuri, Soumya, Moody, D Branch, Suliman, Sara, Gutierrez-Arcelus, Maria

“…A quarter of humanity is estimated to have been exposed to Mycobacterium tuberculosis (Mtb) with a 5-10% risk of developing tuberculosis (TB) disease…”
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Detergent-induced quantitatively limited formation of diacyl phosphatidylinositol dimannoside in Mycobacterium smegmatis by Kitzmiller, Claire E., Cheng, Tan-Yun, Prandi, Jacques, Sparks, Ian L., Moody, D. Branch, Morita, Yasu S.

“…Mycobacterial plasma membrane, together with the peptidoglycan-arabinogalactan cell wall and waxy outer membrane, creates a robust permeability barrier against…”
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ER stress in antigen‐presenting cells promotes NKT cell activation through endogenous neutral lipids by Govindarajan, Srinath, Verheugen, Eveline, Venken, Koen, Gaublomme, Djoere, Maelegheer, Margaux, Cloots, Eva, Gysens, Fien, De Geest, Bruno G, Cheng, Tan‐Yun, Moody, D Branch, Janssens, Sophie, Drennan, Michael, Elewaut, Dirk

“…CD1d‐restricted invariant natural killer T (iNKT) cells constitute a common glycolipid‐reactive innate‐like T‐cell subset with a broad impact on innate and…”
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