Search Results - "Branca, Maria F"

Toll-like receptor 4-mediated lymphocyte influx induces neonatal necrotizing enterocolitis by Egan, Charlotte E, Sodhi, Chhinder P, Good, Misty, Lin, Joyce, Jia, Hongpeng, Yamaguchi, Yukihiro, Lu, Peng, Ma, Congrong, Branca, Maria F, Weyandt, Samantha, Fulton, William B, Niño, Diego F, Prindle, Jr, Thomas, Ozolek, John A, Hackam, David J

“…The nature and role of the intestinal leukocytes in necrotizing enterocolitis (NEC), a severe disease affecting premature infants, remain unknown. We now show…”
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Mitochondrial structure, function and dynamics are temporally controlled by c-Myc by Graves, J Anthony, Wang, Yudong, Sims-Lucas, Sunder, Cherok, Edward, Rothermund, Kristi, Branca, Maria F, Elster, Jennifer, Beer-Stolz, Donna, Van Houten, Bennett, Vockley, Jerry, Prochownik, Edward V

“…Although the c-Myc (Myc) oncoprotein controls mitochondrial biogenesis and multiple enzymes involved in oxidative phosphorylation (OXPHOS), the coordination of…”
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A Critical Role for TLR4 in the Pathogenesis of Necrotizing Enterocolitis by Modulating Intestinal Injury and Repair by Leaphart, Cynthia L, Cavallo, Jaime, Gribar, Steven C, Cetin, Selma, Li, Jun, Branca, Maria F, Dubowski, Theresa D, Sodhi, Chhinder P, Hackam, David J

“…Necrotizing enterocolitis (NEC) is the leading cause of death from gastrointestinal disease in preterm infants and is characterized by translocation of LPS…”
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Endothelial TLR4 activation impairs intestinal microcirculatory perfusion in necrotizing enterocolitis via eNOS–NO–nitrite signaling by Yazji, Ibrahim, Sodhi, Chhinder P., Lee, Elizabeth K., Good, Misty, Egan, Charlotte E., Afrazi, Amin, Neal, Matthew D., Jia, Hongpeng, Lin, Joyce, Ma, Congrong, Branca, Maria F., Prindle, Thomas, Richardson, Ward M., Ozolek, John, Billiar, Timothy R., Binion, David G., Gladwin, Mark T., Hackam, David J.

“…Necrotizing enterocolitis (NEC) is a devastating disease of premature infants characterized by severe intestinal necrosis and for which breast milk represents…”
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Toll-like Receptor 4-mediated Endoplasmic Reticulum Stress in Intestinal Crypts Induces Necrotizing Enterocolitis by Afrazi, Amin, Branca, Maria F., Sodhi, Chhinder P., Good, Misty, Yamaguchi, Yukihiro, Egan, Charlotte E., Lu, Peng, Jia, Hongpeng, Shaffiey, Shahab, Lin, Joyce, Ma, Congrong, Vincent, Garrett, Thomas, Prindle, Weyandt, Samantha, Neal, Matthew D., Ozolek, John A., Wiersch, John, Tschurtschenthaler, Markus, Shiota, Chiyo, Gittes, George K., Billiar, Timothy R., Mollen, Kevin, Kaser, Arthur, Blumberg, Richard, Hackam, David J.

“…The cellular cues that regulate the apoptosis of intestinal stem cells (ISCs) remain incompletely understood, yet may play a role in diseases characterized by…”
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Animal models of gastrointestinal and liver diseases. Animal models of necrotizing enterocolitis: pathophysiology, translational relevance, and challenges by Lu, Peng, Sodhi, Chhinder P, Jia, Hongpeng, Shaffiey, Shahab, Good, Misty, Branca, Maria F, Hackam, David J

“…Necrotizing enterocolitis is the leading cause of morbidity and mortality from gastrointestinal disease in premature infants and is characterized by initial…”
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A critical role for TLR4 induction of autophagy in the regulation of enterocyte migration and the pathogenesis of necrotizing enterocolitis by Neal, Matthew D, Sodhi, Chhinder P, Dyer, Mitchell, Craig, Brian T, Good, Misty, Jia, Hongpeng, Yazji, Ibrahim, Afrazi, Amin, Richardson, Ward M, Beer-Stolz, Donna, Ma, Congrong, Prindle, Thomas, Grant, Zachary, Branca, Maria F, Ozolek, John, Hackam, David J

“…Necrotizing enterocolitis (NEC) develops in response to elevated TLR4 signaling in the newborn intestinal epithelium and is characterized by TLR4-mediated…”
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Amniotic fluid inhibits Toll-like receptor 4 signaling in the fetal and neonatal intestinal epithelium by Good, Misty, Siggers, Richard H, Sodhi, Chhinder P, Afrazi, Amin, Alkhudari, Feras, Egan, Charlotte E, Neal, Matthew D, Yazji, Ibrahim, Jia, Hongpeng, Lin, Joyce, Branca, Maria F, Ma, Congrong, Prindle, Thomas, Grant, Zachary, Shah, Sapana, Slagle, Dennis, Paredes, Jose, Ozolek, John, Gittes, George K, Hackam, David J

“…The fetal intestinal mucosa is characterized by elevated Toll-like receptor 4 (TLR4) expression, which can lead to the development of necrotizing enterocolitis…”
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Intracellular heat shock protein-70 negatively regulates TLR4 signaling in the newborn intestinal epithelium by Afrazi, Amin, Sodhi, Chhinder P, Good, Misty, Jia, Hongpeng, Siggers, Richard, Yazji, Ibrahim, Ma, Congrong, Neal, Matthew D, Prindle, Thomas, Grant, Zachary S, Branca, Maria F, Ozolek, John, Chang, Eugene B, Hackam, David J

“…Necrotizing enterocolitis (NEC) is the leading cause of gastrointestinal-related mortality in premature infants, and it develops under conditions of…”
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Hypoxia causes an increase in phagocytosis by macrophages in a HIF-1α-dependent manner by Anand, Rahul J., Gribar, Steven C., Li, Jun, Kohler, Jeff W., Branca, Maria F., Dubowski, Theresa, Sodhi, Chhinder P., Hackam, David J.

“…Phagocytosis is the process by which microbial pathogens are engulfed by macrophages and neutrophils and represents the first line of defense against bacterial…”
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Intestinal Epithelial Toll-Like Receptor 4 Regulates Goblet Cell Development and Is Required for Necrotizing Enterocolitis in Mice by Sodhi, Chhinder P, Neal, Matthew D, Siggers, Richard, Sho, Shonan, Ma, Congrong, Branca, Maria F, Prindle, Thomas, Russo, Anthony M, Afrazi, Amin, Good, Misty, Brower–Sinning, Rachel, Firek, Brian, Morowitz, Michael J, Ozolek, John A, Gittes, George K, Billiar, Timothy R, Hackam, David J

“…Background & Aims Little is known about factors that regulate intestinal epithelial differentiation; microbial recognition receptors such as Toll-like receptor…”
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Toll-like Receptor 4 Is Expressed on Intestinal Stem Cells and Regulates Their Proliferation and Apoptosis via the p53 Up-regulated Modulator of Apoptosis by Neal, Matthew D., Sodhi, Chhinder P., Jia, Hongpeng, Dyer, Mitchell, Egan, Charlotte E., Yazji, Ibrahim, Good, Misty, Afrazi, Amin, Marino, Ryan, Slagle, Dennis, Ma, Congrong, Branca, Maria F., Prindle, Thomas, Grant, Zachary, Ozolek, John, Hackam, David J.

“…Factors regulating the proliferation and apoptosis of intestinal stem cells (ISCs) remain incompletely understood. Because ISCs exist among microbial ligands,…”
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Continuum Model of Collective Cell Migration in Wound Healing and Colony Expansion by Arciero, Julia C., Mi, Qi, Branca, Maria F., Hackam, David J., Swigon, David

“…Collective cell migration plays an important role during wound healing and embryo development. Although the exact mechanisms that coordinate such migration are…”
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Reciprocal Expression and Signaling of TLR4 and TLR9 in the Pathogenesis and Treatment of Necrotizing Enterocolitis by Gribar, Steven C, Sodhi, Chhinder P, Richardson, Ward M, Anand, Rahul J, Gittes, George K, Branca, Maria F, Jakub, Adam, Shi, Xia-hua, Shah, Sohail, Ozolek, John A, Hackam, David J

“…Necrotizing enterocolitis (NEC) is a common and often fatal inflammatory disorder affecting preterm infants that develops upon interaction of indigenous…”
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A Role for Connexin43 in Macrophage Phagocytosis and Host Survival after Bacterial Peritoneal Infection by Anand, Rahul J, Dai, Shipan, Gribar, Steven C, Richardson, Ward, Kohler, Jeff W, Hoffman, Rosemary A, Branca, Maria F, Li, Jun, Shi, Xiao-Hua, Sodhi, Chhinder P, Hackam, David J

“…The pathways that lead to the internalization of pathogens via phagocytosis remain incompletely understood. We now demonstrate a previously unrecognized role…”
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Increased expression and internalization of the endotoxin coreceptor CD14 in enterocytes occur as an early event in the development of experimental necrotizing enterocolitis by Mollen, Kevin P, Gribar, Steven C, Anand, Rahul J, Kaczorowski, David J, Kohler, Jeffrey W, Branca, Maria F, Dubowski, Theresa D, Sodhi, Chhinder P, Hackam, David J

“…Abstract Background The early signaling events in the development of necrotizing enterocolitis (NEC) remain undefined. We have recently shown that the…”
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Development of an RNAi therapeutic for alpha-1-antitrypsin liver disease by Wooddell, Christine I, Blomenkamp, Keith, Peterson, Ryan M, Subbotin, Vladimir M, Schwabe, Christian, Hamilton, James, Chu, Qili, Christianson, Dawn R, Hegge, Julia O, Kolbe, John, Hamilton, Holly L, Branca-Afrazi, Maria F, Given, Bruce D, Lewis, David L, Gane, Edward, Kanner, Steven B, Teckman, Jeffrey H

“…The autosomal codominant genetic disorder alpha-1 antitrypsin (AAT) deficiency (AATD) causes pulmonary and liver disease. Individuals homozygous for the mutant…”
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Relationships between Transforming Growth Factor-β1, Myostatin, and Decorin by Zhu, Jinhong, Li, Yong, Shen, Wei, Qiao, Chunping, Ambrosio, Fabrisia, Lavasani, Mitra, Nozaki, Masahiro, Branca, Maria F., Huard, Johnny

“…Recent studies have shown that myostatin, first identified as a negative regulator of skeletal muscle growth, may also be involved in the formation of fibrosis…”
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The proinflammatory danger molecule HMGB1 signals via the innate immune receptor TLR4 in the intestinal microvasculature: A novel paradigm in the pathogenesis of NEC by Richardson, Ward M., MD, Afrazi, Amin, BS, Sodhi, Chhinder C., PhD, Russo, Anthony, BS, Branca, Maria F., BS, Prindle, Thomas, BS, Hackam, David J., MD, PhD, FACS

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78. NOD2 Activation Leads to an Inhibition of TLR4-Mediated Signaling in Enterocytes: A Role for Receptor Cross-Talk in the Pathogenesis of Intestinal Inflammation by Richardson, Ward M, Atsina, Komli-Kofi, Gribar, Steven C, Sodhi, C.P, Li, Jun, Branca, Maria F, Dubowski, Theresa D, Hackam, David J

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