Search Results - "Bramham, Clive"

Arc/Arg3.1 function in long‐term synaptic plasticity: Emerging mechanisms and unresolved issues by Zhang, Hongyu, Bramham, Clive R.

“…Arc (activity‐regulated cytoskeleton‐associated protein) is posited as a critical regulator of long‐term synaptic plasticity at excitatory synapses, including…”
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BDNF mechanisms in late LTP formation: A synthesis and breakdown by Panja, Debabrata, Bramham, Clive R.

“…Unraveling the molecular mechanisms governing long-term synaptic plasticity is a key to understanding how the brain stores information in neural circuits and…”
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Local protein synthesis, actin dynamics, and LTP consolidation by Bramham, Clive R

“…Modulation of local protein synthesis in neuronal dendrites plays a key role in the production of long-term, activity-dependent changes in synapse structure…”
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Antidepressant drugs act by directly binding to TRKB neurotrophin receptors by Casarotto, Plinio C., Girych, Mykhailo, Fred, Senem M., Kovaleva, Vera, Moliner, Rafael, Enkavi, Giray, Biojone, Caroline, Cannarozzo, Cecilia, Sahu, Madhusmita Pryiadrashini, Kaurinkoski, Katja, Brunello, Cecilia A., Steinzeig, Anna, Winkel, Frederike, Patil, Sudarshan, Vestring, Stefan, Serchov, Tsvetan, Diniz, Cassiano R.A.F., Laukkanen, Liina, Cardon, Iseline, Antila, Hanna, Rog, Tomasz, Piepponen, Timo Petteri, Bramham, Clive R., Normann, Claus, Lauri, Sari E., Saarma, Mart, Vattulainen, Ilpo, Castrén, Eero

“…It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane…”
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CREB Family Transcription Factors Are Major Mediators of BDNF Transcriptional Autoregulation in Cortical Neurons by Esvald, Eli-Eelika, Tuvikene, Jürgen, Sirp, Alex, Patil, Sudarshan, Bramham, Clive R, Timmusk, Tõnis

“…BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal survival, differentiation, and synaptic plasticity. Remarkably, BDNF is…”
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Arc protein: a flexible hub for synaptic plasticity and cognition by Nikolaienko, Oleksii, Patil, Sudarshan, Eriksen, Maria Steene, Bramham, Clive R.

“…•Arc is a multifunctional hub protein.•Arc is flexible, modular and capable of reversible self-oligomerization.•Arc localization and stability are regulated by…”
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Tuning Specific Translation in Cancer Metastasis and Synaptic Memory: Control at the MNK–eIF4E Axis by Bramham, Clive R., Jensen, Kirk B., Proud, Christopher G.

“…The eukaryotic translation initiation factor (eIF) 4E, which binds to the 5’-cap of mRNA, undergoes phosphorylation on a single conserved serine, executed by…”
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BDNF function in adult synaptic plasticity: the synaptic consolidation hypothesis by Bramham, Clive R, Messaoudi, Elhoucine

“…Interest in BDNF as an activity-dependent modulator of neuronal structure and function in the adult brain has intensified in recent years. Localization of…”
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A simple DMSO-based method for cryopreservation of primary hippocampal and cortical neurons by Ishizuka, Yuta, Bramham, Clive R.

“…[Display omitted] •Cell viability of cryopreserved neurons is comparable to freshly prepared neurons.•Maturation of cryopreserved neurons is equivalent to…”
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Molecular physiology of Arc/Arg3.1: The oligomeric state hypothesis of synaptic plasticity by Eriksen, Maria Steene, Bramham, Clive R.

“…The immediate early gene, Arc, is a pivotal regulator of synaptic plasticity, memory, and cognitive flexibility. But what is Arc protein? How does it work?…”
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Dendritic mRNA: transport, translation and function by Bramham, Clive R, Wells, David G

“…Many cellular functions require the synthesis of a specific protein or functional cohort of proteins at a specific time and place in the cell. Local protein…”
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Bidirectional Dysregulation of AMPA Receptor-Mediated Synaptic Transmission and Plasticity in Brain Disorders by Zhang, Hongyu, Bramham, Clive R.

“…AMPA receptors (AMPARs) are glutamate-gated ion channels that mediate the majority of fast excitatory synaptic transmission throughout the brain. Changes in…”
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Two-Stage Translational Control of Dentate Gyrus LTP Consolidation Is Mediated by Sustained BDNF-TrkB Signaling to MNK by Panja, Debabrata, Kenney, Justin W., D’Andrea, Laura, Zalfa, Francesca, Vedeler, Anni, Wibrand, Karin, Fukunaga, Rikiro, Bagni, Claudia, Proud, Christopher G., Bramham, Clive R.

“…BDNF signaling contributes to protein-synthesis-dependent synaptic plasticity, but the dynamics of TrkB signaling and mechanisms of translation have not been…”
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Stimulus-evoked ERK-dependent phosphorylation of activity-regulated cytoskeleton-associated protein (Arc) regulates its neuronal subcellular localization by Nikolaienko, Oleksii, Eriksen, Maria Steene, Patil, Sudarshan, Bito, Haruhiko, Bramham, Clive R.

“…•ERK binds a non-canonical docking motif in the Arc C-terminal domain.•In vitro kinase assays identify five ERK phosphorylation sites on Arc.•Stimulus-evoked…”
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High-affinity anti-Arc nanobodies provide tools for structural and functional studies by Markússon, Sigurbjörn, Hallin, Erik I, Bustad, Helene J, Raasakka, Arne, Xu, Ju, Muruganandam, Gopinath, Loris, Remy, Martinez, Aurora, Bramham, Clive R, Kursula, Petri

“…Activity-regulated cytoskeleton-associated protein (Arc) is a multidomain protein of retroviral origin with a vital role in the regulation of synaptic…”
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The Immediate Early Gene Arc/Arg3.1: Regulation, Mechanisms, and Function by Bramham, Clive R, Worley, Paul F, Moore, Melissa J, Guzowski, John F

“…In a manner unique among activity-regulated immediate early genes (IEGs), mRNA encoded by Arc (also known as Arg3.1) undergoes rapid transport to dendrites and…”
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A Nanobody-Based Proximity Ligation Assay Detects Constitutive and Stimulus-Regulated Native Arc/Arg3.1 Oligomers in Hippocampal Neuronal Dendrites by Baldinotti, Rodolfo, Pauzin, Francois P, Fevang, Hauk, Ishizuka, Yuta, Bramham, Clive R

“…Activity-regulated cytoskeleton-associated protein (Arc), the product of an immediate early gene, plays critical roles in synaptic plasticity and memory…”
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Crystal and solution structures reveal oligomerization of individual capsid homology domains of Drosophila Arc by Hallin, Erik I, Markússon, Sigurbjörn, Böttger, Lev, Torda, Andrew E, Bramham, Clive R, Kursula, Petri

“…Synaptic plasticity is vital for brain function and memory formation. One of the key proteins in long-term synaptic plasticity and memory is the…”
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eEF2/eEF2K Pathway in the Mature Dentate Gyrus Determines Neurogenesis Level and Cognition by Taha, Elham, Patil, Sudarshan, Barrera, Iliana, Panov, Julia, Khamaisy, Mohammad, Proud, Christopher G., Bramham, Clive R., Rosenblum, Kobi

“…Levels of adult neurogenesis in the dentate gyrus (DG) of the hippocampus are correlated with unique cognitive functions. However, the molecular pathways…”
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BDNF-induced LTP is associated with rapid Arc/Arg3.1-dependent enhancement in adult hippocampal neurogenesis by Kuipers, Sjoukje D., Trentani, Andrea, Tiron, Adrian, Mao, Xiaosong, Kuhl, Dietmar, Bramham, Clive R.

“…Adult neurogenesis in the hippocampus is a remarkable phenomenon involved in various aspects of learning and memory as well as disease pathophysiology…”
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