Search Results - "Bramato, Brianna"

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis by Min, Kyounghee, Yenilmez, Batuhan, Kelly, Mark, Echeverria, Dimas, Elleby, Michael, Lifshitz, Lawrence M, Raymond, Naideline, Tsagkaraki, Emmanouela, Harney, Shauna M, DiMarzio, Chloe, Wang, Hui, McHugh, Nicholas, Bramato, Brianna, Morrison, Brett, Rothstein, Jeffery D, Khvorova, Anastasia, Czech, Michael P

“…Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed,…”
Get full text

Rational design of a JAK1-selective siRNA inhibitor for the modulation of autoimmunity in the skin by Tang, Qi, Fakih, Hassan H., Zain UI Abideen, Mohammad, Hildebrand, Samuel R., Afshari, Khashayar, Gross, Katherine Y., Sousa, Jacquelyn, Maebius, Allison S., Bartholdy, Christina, Søgaard, Pia Pernille, Jackerott, Malene, Hariharan, Vignesh, Summers, Ashley, Fan, Xueli, Okamura, Ken, Monopoli, Kathryn R., Cooper, David A., Echeverria, Dimas, Bramato, Brianna, McHugh, Nicholas, Furgal, Raymond C., Dresser, Karen, Winter, Sarah J., Biscans, Annabelle, Chuprin, Jane, Haddadi, Nazgol-Sadat, Sherman, Shany, Yıldız-Altay, Ümmügülsüm, Rashighi, Mehdi, Richmond, Jillian M., Bouix-Peter, Claire, Blanchard, Carine, Clauss, Adam, Alterman, Julia F., Khvorova, Anastasia, Harris, John E.

“…Inhibition of Janus kinase (JAK) family enzymes is a popular strategy for treating inflammatory and autoimmune skin diseases. In the clinic, small molecule JAK…”
Get full text

Enhancing siRNA efficacy in vivo with extended nucleic acid backbones by Yamada, Ken, Hariharan, Vignesh N, Caiazzi, Jillian, Miller, Rachael, Ferguson, Chantal M, Sapp, Ellen, Fakih, Hassan H, Tang, Qi, Yamada, Nozomi, Furgal, Raymond C, Paquette, Joseph D, Biscans, Annabelle, Bramato, Brianna M, McHugh, Nicholas, Summers, Ashley, Lochmann, Clemens, Godinho, Bruno M D C, Hildebrand, Samuel, Jackson, Samuel O, Echeverria, Dimas, Hassler, Matthew R, Alterman, Julia F, DiFiglia, Marian, Aronin, Neil, Khvorova, Anastasia

“…Therapeutic small interfering RNA (siRNA) requires sugar and backbone modifications to inhibit nuclease degradation. However, metabolic stabilization by…”
Get full text

Preventing acute neurotoxicity of CNS therapeutic oligonucleotides with the addition of Ca2+ and Mg2+ in the formulation by Miller, Rachael, Paquette, Joseph, Barker, Alexandra, Sapp, Ellen, McHugh, Nicholas, Bramato, Brianna, Yamada, Nozomi, Alterman, Julia, Echeveria, Dimas, Yamada, Ken, Watts, Jonathan, Anaclet, Christelle, DiFiglia, Marian, Khvorova, Anastasia, Aronin, Neil

“…Oligonucleotide therapeutics (ASOs and siRNAs) have been explored for modulation of gene expression in the central nervous system (CNS), with several drugs…”
Get full text

Identification of selective and non-selective C9ORF72 targeting in vivo active siRNAs by Gilbert, James W., Kennedy, Zachary, Godinho, Bruno M.D.C., Summers, Ashley, Weiss, Alexandra, Echeverria, Dimas, Bramato, Brianna, McHugh, Nicholas, Cooper, David, Yamada, Ken, Hassler, Matthew, Tran, Hélène, Gao, Fen Biao, Brown, Robert H., Khvorova, Anastasia

“…A hexanucleotide (G4C2) repeat expansion (HRE) within intron one of C9ORF72 is the leading genetic cause of amyotrophic lateral sclerosis (ALS) and…”
Get full text

A programmable dual-targeting siRNA scaffold supports potent two-gene modulation in the central nervous system by Belgrad, Jillian, Tang, Qi, Hildebrand, Sam, Summers, Ashley, Sapp, Ellen, Echeverria, Dimas, O'Reilly, Dan, Luu, Eric, Bramato, Brianna, Allen, Sarah, Cooper, David, Alterman, Julia, Yamada, Ken, Aronin, Neil, DiFiglia, Marian, Khvorova, Anastasia

“…Divalent short-interfering RNA (siRNA) holds promise as a therapeutic approach allowing for the sequence-specific modulation of a target gene within the…”
Get full text

mRNA Nuclear Clustering Leads to a Difference in Mutant Huntingtin mRNA and Protein Silencing by siRNAs In Vivo by Allen, Sarah, O'Reilly, Daniel, Miller, Rachael, Sapp, Ellen, Summers, Ashley, Paquette, Joseph, Echeverria Moreno, Dimas, Bramato, Brianna, McHugh, Nicholas, Yamada, Ken, Aronin, Neil, DiFiglia, Marian, Khvorova, Anastasia

“…Huntington's disease (HD) is an autosomal dominant neurodegenerative disease caused by CAG repeat expansion in the first exon of the huntingtin gene ( )…”
Get more information

Lactate transporter MCT1 in hepatic stellate cells promotes fibrotic collagen expression in nonalcoholic steatohepatitis by Min, Kyounghee, Yenilmez, Batuhan, Kelly, Mark, Echeverria, Dimas, Elleby, Michael, Lifshitz, Lawrence M, Raymond, Naideline, Tsagkaraki, Emmanouela, Harney, Shauna M, DiMarzio, Chloe, Wang, Hui, McHugh, Nicholas, Bramato, Brianna, Morrison, Brett, Rothstein, Jeffery D, Khvorova, Anastasia, Czech, Michael P

“…Circulating lactate is a fuel source for liver metabolism but may exacerbate metabolic diseases such as nonalcoholic steatohepatitis (NASH). Indeed,…”
Get full text