Search Results - "Brama, Pieter A J"

The benefits and limitations of animal models for translational research in cartilage repair by Moran, Conor J., Ramesh, Ashwanth, Brama, Pieter A. J., O’Byrne, John M., O’Brien, Fergal J., Levingstone, Tanya J.

“…Much research is currently ongoing into new therapies for cartilage defect repair with new biomaterials frequently appearing which purport to have significant…”
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Effectiveness of BMP-2 and PDGF-BB Adsorption onto a Collagen/Collagen-Magnesium-Hydroxyapatite Scaffold in Weight-Bearing and Non-Weight-Bearing Osteochondral Defect Bone Repair: In Vitro, Ex Vivo and In Vivo Evaluation by Xu, Jietao, Fahmy-Garcia, Shorouk, Wesdorp, Marinus A, Kops, Nicole, Forte, Lucia, De Luca, Claudio, Misciagna, Massimiliano Maraglino, Dolcini, Laura, Filardo, Giuseppe, Labberté, Margot, Vancíková, Karin, Kok, Joeri, van Rietbergen, Bert, Nickel, Joachim, Farrell, Eric, Brama, Pieter A J, van Osch, Gerjo J V M

“…Despite promising clinical results in osteochondral defect repair, a recently developed bi-layered collagen/collagen-magnesium-hydroxyapatite scaffold has…”
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A Translational Model for Repeated Episodes of Joint Inflammation: Welfare, Clinical and Synovial Fluid Biomarker Assessment by Kearney, Clodagh M, Korthagen, Nicoline M, Plomp, Saskia G M, Labberté, Margot C, de Grauw, Janny C, van Weeren, P René, Brama, Pieter A J

“…This study investigates repeated low-dose lipopolysaccharide (LPS) injections in equine joints as a model for recurrent joint inflammation and its impact on…”
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3D printing of fibre-reinforced cartilaginous templates for the regeneration of osteochondral defects by Critchley, Susan, Sheehy, Eamon J., Cunniffe, Gráinne, Diaz-Payno, Pedro, Carroll, Simon F., Jeon, Oju, Alsberg, Eben, Brama, Pieter A.J., Kelly, Daniel J.

“…Successful osteochondral defect repair requires regenerating the subchondral bone whilst simultaneously promoting the development of an overlying layer of…”
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Cell-free multi-layered collagen-based scaffolds demonstrate layer specific regeneration of functional osteochondral tissue in caprine joints by Levingstone, Tanya J, Ramesh, Ashwanth, Brady, Robert T, Brama, Pieter A.J, Kearney, Clodagh, Gleeson, John P, O'Brien, Fergal J

“…Abstract Developing repair strategies for osteochondral tissue presents complex challenges due to its interfacial nature and complex zonal structure,…”
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The Feasibility of Equine Field-Based Postural Sway Analysis Using a Single Inertial Sensor by Egan, Sonja, Brama, Pieter A J, Goulding, Cathy, McKeown, David, Kearney, Clodagh M, McGrath, Denise

“…(1) Background: Postural sway is frequently used to quantify human postural control, balance, injury, and neurological deficits. However, there is considerably…”
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Bilayered extracellular matrix derived scaffolds with anisotropic pore architecture guide tissue organization during osteochondral defect repair by Browe, David C., Díaz-Payno, Pedro J., Freeman, Fiona E., Schipani, Rossana, Burdis, Ross, Ahern, Daniel P., Nulty, Jessica M., Guler, Selcan, Randall, Lindsey D., Buckley, Conor T., Brama, Pieter A.J., Kelly, Daniel J.

“…While some clinical advances in cartilage repair have occurred, osteochondral (OC) defect repair remains a significant challenge, with current scaffold-based…”
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Chondrogenically Primed Human Mesenchymal Stem Cells Persist and Undergo Early Stages of Endochondral Ossification in an Immunocompetent Xenogeneic Model by Fahy, Niamh, Palomares Cabeza, Virginia, Lolli, Andrea, Witte-Bouma, Janneke, Merino, Ana, Ridwan, Yanto, Wolvius, Eppo B, Hoogduijn, Martin J, Farrell, Eric, Brama, Pieter A J

“…Tissue engineering approaches using progenitor cells such as mesenchymal stromal cells (MSCs) represent a promising strategy to regenerate bone. Previous work…”
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The Immune Response to Allogeneic Differentiated Mesenchymal Stem Cells in the Context of Bone Tissue Engineering by Kiernan, Caoimhe H, Wolvius, Eppo B, Brama, Pieter A J, Farrell, Eric

“…The use of allogeneic differentiated mesenchymal stem cells (MSCs) to mediate bone formation may be a potential alternative to the current gold standards of…”
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Preclinical to clinical translation for intervertebral disc repair: Effects of species‐specific scale, metabolism, and matrix synthesis rates on cell‐based regeneration by McDonnell, Emily E., Wilson, Niamh, Barcellona, Marcos N., Ní Néill, Tara, Bagnall, Jessica, Brama, Pieter A. J., Cunniffe, Gráinne M., Darwish, Stacey L., Butler, Joseph S., Buckley, Conor T.

“…Abstract Background A significant hurdle for potential cell‐based therapies is the subsequent survival and regenerative capacity of implanted cells. While many…”
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Pediatric Mesenchymal Stem Cells Exhibit Immunomodulatory Properties Toward Allogeneic T and B Cells Under Inflammatory Conditions by Palomares Cabeza, Virginia, Hoogduijn, Martin Johannes, Kraaijeveld, Rens, Franquesa, Marcella, Witte-Bouma, Janneke, Wolvius, Eppo B, Farrell, Eric, Brama, Pieter A J

“…Mesenchymal stem cells from pediatric patients (pMSCs) are an attractive cell source in regenerative medicine, due to their higher proliferation rates and…”
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Nitrite and nitrotyrosine concentrations in articular cartilage, subchondral bone, and trabecular bone of normal juvenile, normal adult, and osteoarthritic adult equine metacarpophalangeal joints by VAN DER HARST, Mark R, BULL, Sarah, BRAMA, Pieter A. J, BARNEVELD, A. B, VAN WEEREN, P. René, VAN DE LEST, Chris H. A

“…OBJECTIVE: Osteoarthritis (OA) is a chronic debilitating joint disorder in which the importance of inflammation is increasingly recognized. In advanced cases,…”
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Treatment Effects of Intra-Articular Allogenic Mesenchymal Stem Cell Secretome in an Equine Model of Joint Inflammation by Kearney, Clodagh M., Khatab, Sohrab, van Buul, Gerben M., Plomp, Saskia G. M., Korthagen, Nicoline M., Labberté, Margot C., Goodrich, Laurie R., Kisiday, John D., Van Weeren, P. R., van Osch, Gerjo J. V. M., Brama, Pieter A. J.

“…Background Allogenic mesenchymal stem cell (MSC) secretome is a novel intra-articular therapeutic that has shown promise in in vitro and small animal models…”
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Osteochondral repair: evaluation with sweep imaging with fourier transform in an equine model by Rautiainen, Jari, Lehto, Lauri J, Tiitu, Virpi, Kiekara, Outi, Pulkkinen, Hertta, Brünott, Anne, van Weeren, René, Brommer, Harold, Brama, Pieter A J, Ellermann, Jutta, Kiviranta, Ilkka, Nieminen, Miika T, Nissi, Mikko J

“…To evaluate the status of articular cartilage and bone in an equine model of spontaneous repair by using the sweep imaging with Fourier transform (SWIFT)…”
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Changes in subchondral bone mineral density and collagen matrix organization in growing horses by Holopainen, Jaakko T, Brama, Pieter A.J, Halmesmäki, Esa, Harjula, Terhi, Tuukkanen, Juha, van Weeren, P. René, Helminen, Heikki J, Hyttinen, Mika M

“…Abstract Objective The effects of growth and maturation on the mineral deposition and the collagen framework of equine subchondral bone (SCB) were studied…”
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Tissue-specific extracellular matrix scaffolds for the regeneration of spatially complex musculoskeletal tissues by Cunniffe, Gráinne M., Díaz-Payno, Pedro J., Sheehy, Eamon J., Critchley, Susan E., Almeida, Henrique V., Pitacco, Pierluca, Carroll, Simon F., Mahon, Olwyn R., Dunne, Aisling, Levingstone, Tanya J., Moran, Conor J., Brady, Robert T., O'Brien, Fergal J., Brama, Pieter A.J., Kelly, Daniel J.

“…Biological scaffolds generated from tissue-derived extracellular matrix (ECM) are commonly used clinically for soft tissue regeneration. Such biomaterials can…”
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Changes in collagen fibril network organization and proteoglycan distribution in equine articular cartilage during maturation and growth by Hyttinen, Mika M., Holopainen, Jaakko, René van Weeren, P., Firth, Elwyn C., Helminen, Heikki J., Brama, Pieter A. J.

“…The aim of this study was to record growth‐related changes in collagen network organization and proteoglycan distribution in intermittently peak‐loaded and…”
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Bone formation by human paediatric marrow stromal cells in a functional allogeneic immune system by Palomares Cabeza, Virginia, Fahy, Niamh, Kiernan, Caoimhe H., Lolli, Andrea, Witte-Bouma, Janneke, Fahmy Garcia, Shorouk, Merino, Ana, Kops, Nicole, Ridwan, Yanto, Wolvius, Eppo B., Brama, Pieter A.J., Hoogduijn, Martin J., Farrell, Eric

“…Allogeneic stem-cell based regenerative medicine is a promising approach for bone defect repair. The use of chondrogenically differentiated human marrow…”
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Treatment effects of intra‐articular triamcinolone acetonide in an equine model of recurrent joint inflammation by Kearney, Clodagh M., Korthagen, Nicoline M., Plomp, Saskia G. M., Labberté, Margot C., Grauw, Janny C., Weeren, P. R., Brama, Pieter A. J.

“…Background Intra‐articular triamcinolone acetonide is a widely used treatment for joint inflammation despite limited scientific evidence of its efficacy…”
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Long-Term Expansion, Enhanced Chondrogenic Potential, and Suppression of Endochondral Ossification of Adult Human MSCs via WNT Signaling Modulation by Narcisi, Roberto, Cleary, Mairéad A., Brama, Pieter A.J., Hoogduijn, Martin J., Tüysüz, Nesrin, ten Berge, Derk, van Osch, Gerjo J.V.M.

“…Mesenchymal stem cells (MSCs) are a potential source of chondrogenic cells for the treatment of cartilage disorders, but loss of chondrogenic potential during…”
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