Search Results - "Bram, Richard J."

Cycloheximide promotes paraptosis induced by inhibition of cyclophilins in glioblastoma multiforme by Wang, Lin, Gundelach, Justin H, Bram, Richard J

“…Cancer is the second leading cause of death worldwide. Current treatment strategies based on multi-agent chemotherapy and/or radiation regimens have improved…”
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Chemotherapy-induced cellular senescence suppresses progression of Notch-driven T-ALL by Zhang, Ying, Gundelach, Justin, Lindquist, Lonnie D, Baker, Darren J, van Deursen, Jan, Bram, Richard J

“…T cell acute lymphoblastic leukemia (T-ALL) is a serious hematologic malignancy that occurs in children and young adults. Current therapies include intensive…”
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Cyclophilin B Supports Myc and Mutant p53-Dependent Survival of Glioblastoma Multiforme Cells by JAE WON CHOI, SCHROEDER, Mark A, SARKARIA, Jann N, BRAM, Richard J

“…Glioblastoma multiforme is an aggressive, treatment-refractory type of brain tumor for which effective therapeutic targets remain important to identify. Here,…”
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TACI and BAFF-R mediate isotype switching in B cells by Castigli, Emanuela, Wilson, Stephen A, Scott, Sumi, Dedeoglu, Fatma, Xu, Shengli, Lam, Kong-Peng, Bram, Richard J, Jabara, Haifa, Geha, Raif S

“…The tumor necrosis factor family members BAFF and APRIL induce Ig isotype switching in human B cells. We analyzed the ability of BAFF and APRIL to induce…”
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BCMA is essential for the survival of long-lived bone marrow plasma cells by O'Connor, Brian P, Raman, Vanitha S, Erickson, Loren D, Cook, W James, Weaver, Lehn K, Ahonen, Cory, Lin, Ling-Li, Mantchev, George T, Bram, Richard J, Noelle, Randolph J

“…Long-lived humoral immunity is manifested by the ability of bone marrow plasma cells (PCs) to survive for extended periods of time. Recent studies have…”
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Accelerated Aging in Cyclophilin B–Deficient Mice Downstream of p21‐Cip1/Waf1 by Zhang, Ying, Pignolo, Robert J., Bram, Richard J.

“…ABSTRACT Loss of bone mass and strength is a common problem of advanced age in humans. Defective bone is also a primary finding in osteogenesis imperfecta…”
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TLR Stimulation Modifies BLyS Receptor Expression in Follicular and Marginal Zone B Cells by Treml, Laura S, Carlesso, Gianluca, Hoek, Kristen L, Stadanlick, Jason E, Kambayashi, Taku, Bram, Richard J, Cancro, Michael P, Khan, Wasif N

“…Through their differential interactions with B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL), the three BLyS family receptors play…”
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BAFF receptor and TACI in B-1b cell maintenance and antibacterial responses by Dickinson, Gregory S., Akkoyunlu, Mustafa, Bram, Richard J., Alugupalli, Kishore R.

“…Although evidence of the protective immunity conferred by B‐1b cells (CD19+B220+IgMhiMac1+CD5−) has been established, the mechanisms governing the maintenance…”
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Transmembrane activator, calcium modulator, and cyclophilin ligand interactor drives plasma cell differentiation in LPS-activated B cells by Ozcan, Esra, MD, Garibyan, Lilit, PhD, Lee, John Jhe-Yun, MD, Bram, Richard J., MD, Lam, Kong-Peng, PhD, Geha, Raif S., MD

“…Background Transmembrane activator, calcium modulator, and cyclophilin ligand interactor (TACI) expression on B cells is upregulated by Toll-like receptor…”
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Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI by Wolf, Amaya I, Mozdzanowska, Krystyna, Quinn, 3rd, William J, Metzgar, Michele, Williams, Katie L, Caton, Andrew J, Meffre, Eric, Bram, Richard J, Erickson, Loren D, Allman, David, Cancro, Michael P, Erikson, Jan

“…Antiviral Abs, for example those produced in response to influenza virus infection, are critical for virus neutralization and defense against secondary…”
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Efficient B Cell Responses to Borrelia hermsii Infection Depend on BAFF and BAFFR but Not TACI by Dickinson, Gregory S, Sun, Guizhi, Bram, Richard J, Alugupalli, Kishore R

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Aberrant expression of B-lymphocyte stimulator by B chronic lymphocytic leukemia cells: a mechanism for survival by Novak, Anne J., Bram, Richard J., Kay, Neil E., Jelinek, Diane F.

“…B-cell chronic lymphocytic leukemia (B-CLL) is defined by the accumulation of CD5+ B cells in the periphery and bone marrow. This disease is not characterized…”
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TNFRSF13B genotypes control immune-mediated pathology by regulating the functions of innate B cells by de Mattos Barbosa, Mayara Garcia, Lefferts, Adam R, Huynh, Daniel, Liu, Hui, Zhang, Yu, Fu, Beverly, Barnes, Jenna, Samaniego, Milagros, Bram, Richard J, Geha, Raif S, Shikanov, Ariella, Prak, Eline T Luning, Farkash, Evan A, Platt, Jeffrey L, Cascalho, Marilia

“…Host genes define the severity of inflammation and immunity but specific loci doing so are unknown. Here we show that TNF receptor superfamily member 13B…”
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NF-AT Activation Induced by a CAML-Interacting Member of the Tumor Necrosis Factor Receptor Superfamily by von Bülow, Götz-Ulrich, Bram, Richard J.

“…Activation of the nuclear factor of activated T cells transcription factor (NF-AT) is a key event underlying lymphocyte action. The CAML (calcium-modulator and…”
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Immunotherapy in pediatric B-cell acute lymphoblastic leukemia by Wyatt, Kirk D., Bram, Richard J.

“…Advances in multi-agent chemotherapy and supportive care have dramatically improved survival of children with B-cell acute lymphoblastic leukemia (B-ALL);…”
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Kaposi's Sarcoma-Associated Herpesvirus Mitochondrial K7 Protein Targets a Cellular Calcium-Modulating Cyclophilin Ligand To Modulate Intracellular Calcium Concentration and Inhibit Apoptosis by Feng, Pinghui, Park, Junsoo, Lee, Bok-Soo, Lee, Sun-Hwa, Bram, Richard J, Jung, Jae U

“…Article Usage Stats Services JVI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Severe osteogenesis imperfecta in cyclophilin B-deficient mice by Choi, Jae Won, Sutor, Shari L, Lindquist, Lonn, Evans, Glenda L, Madden, Benjamin J, Bergen, 3rd, H Robert, Hefferan, Theresa E, Yaszemski, Michael J, Bram, Richard J

“…Osteogenesis Imperfecta (OI) is a human syndrome characterized by exquisitely fragile bones due to osteoporosis. The majority of autosomal dominant OI cases…”
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TACI deficiency impairs sustained Blimp-1 expression in B cells decreasing long-lived plasma cells in the bone marrow by Tsuji, Shoichiro, Cortesão, Catarina, Bram, Richard J., Platt, Jeffrey L., Cascalho, Marilia

“…Deficiencies in transmembrane activator and CAML interactor (TACI) result in common variable immune deficiency, a syndrome marked by recurrent infections with…”
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CAML loss causes anaphase failure and chromosome missegregation by Liu, Yu, Malureanu, Liviu, Jeganathan, Karthik B., Tran, David Dinh, Lindquist, Lonn D., van Deursen, Jan M., Bram, Richard J.

“…Calcium modulating cyclophilin ligand (CAML) is a ubiquitously expressed cytoplasmic protein that is implicated in the EGFR and LCK signaling pathways and…”
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Enhanced immunogenicity of pneumococcal surface adhesin A (PsaA) in mice via fusion to recombinant human B lymphocyte stimulator (BLyS) by Gor, Dennis O, Ding, Xuedong, Li, Qing, Sultana, Dilara, Mambula, Salamatu S, Bram, Richard J, Greenspan, Neil S

“…B lymphocyte stimulator (BLyS) is a member of the tumor necrosis factor superfamily of ligands that mediates its action through three known receptors. BLyS has…”
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