Search Results - "Bralten, Linda B C"

IDH1 R132H decreases proliferation of glioma cell lines in vitro and in vivo by Bralten, Linda B. C., Kloosterhof, Nanne K., Balvers, Rutger, Sacchetti, Andrea, Lapre, Lariesa, Lamfers, Martine, Leenstra, Sieger, de Jonge, Hugo, Kros, Johan M., Jansen, Erwin E. W., Struys, Eduard A., Jakobs, Cornelis, Salomons, Gajja S., Diks, Sander H., Peppelenbosch, Maikel, Kremer, Andreas, Hoogenraad, Casper C., Sillevis Smitt, Peter A. E., French, Pim J.

“…Objective: A high percentage of grade II and III gliomas have mutations in the gene encoding isocitrate dehydrogenase (IDH1). This mutation is always a…”
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Isocitrate dehydrogenase-1 mutations: a fundamentally new understanding of diffuse glioma? by Kloosterhof, Nanne K, MSc, Bralten, Linda BC, MD, Dubbink, Hendrikus J, PhD, French, Pim J, PhD, van den Bent, Martin J, Prof

“…Summary The discovery of somatic mutations in the gene encoding isocitrate dehydrogenase-1 (IDH1) in glioblastomas was remarkable because the enzyme was not…”
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Exon expression arrays as a tool to identify new cancer genes by Schutte, Mieke, Elstrodt, Fons, Bralten, Linda B C, Nagel, Jord H A, Duijm, Elza, Hollestelle, Antoinette, Vuerhard, Maartje J, Wasielewski, Marijke, Peeters, Justine K, van der Spek, Peter, Sillevis Smitt, Peter A, French, Pim J

“…Identification of genes that are causally implicated in oncogenesis is a major goal in cancer research. An estimated 10-20% of cancer-related gene mutations…”
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Segregation of non-p.R132H mutations in IDH1 in distinct molecular subtypes of glioma by Gravendeel, Lonneke A.M, Kloosterhof, Nanne K, Bralten, Linda B.C, van Marion, Ronald, Dubbink, Hendrikus Jan, Dinjens, Winand, Bleeker, Fonnet E, Hoogenraad, Casper C, Michiels, Erna, Kros, Johan M, van den Bent, Martin, Smitt, Peter A.E. Sillevis, French, Pim J

“…Mutations in the gene encoding the isocitrate dehydrogenase 1 gene (IDH1) occur at a high frequency (up to 80%) in many different subtypes of glioma. In this…”
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Intrinsic Gene Expression Profiles of Gliomas Are a Better Predictor of Survival than Histology by GRAVENDEEL, Lonneke A. M, KOUWENHOVEN, Mathilde C. M, DE MOOR, Bart, EILERS, Paul H. C, VAN DER SPEK, Peter J, KROS, Johan M, SILLEVIS SMITT, Peter A. E, VAN DEN BENT, Martin J, FRENCH, Pim J, GEVAERT, Olivier, DE ROOI, Johan J, STUBBS, Andrew P, ELZA DUIJM, J, DAEMEN, Anneleen, BLEEKER, Fonnet E, BRALTEN, Linda B. C, KLOOSTERHOF, Nanne K

“…Gliomas are the most common primary brain tumors with heterogeneous morphology and variable prognosis. Treatment decisions in patients rely mainly on…”
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Genetic alterations in glioma by Bralten, Linda B C, French, Pim J

“…Gliomas are the most common type of primary brain tumor and have a dismal prognosis. Understanding the genetic alterations that drive glioma formation and…”
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Integrated genomic profiling identifies candidate genes implicated in glioma-genesis and a novel LEO1-SLC12A1 fusion gene by Bralten, Linda B. C., Kloosterhof, Nanne K., Gravendeel, Lonneke A. M., Sacchetti, Andrea, Duijm, Elza J., Kros, Johan M., van den Bent, Martin J., Hoogenraad, Casper C., Sillevis Smitt, Peter A. E., French, Pim J.

“…We performed genotyping and exon‐level expression profiling on 21 glioblastomas (GBMs) and 19 oligodendrogliomas (ODs) to identify genes involved in glioma…”
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